Unveiling the gut-brain axis: structural and functional analogies between the gut and the choroid plexus vascular and immune barriers

Collins SM, Bercik P (2009) The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease. Gastroenterology 136(6):2003–2014. https://doi.org/10.1053/J.GASTRO.2009.01.075

Article  PubMed  Google Scholar 

Negi N, Das BK (2017) CNS: not an immunoprivilaged site anymore but a virtual secondary lymphoid organ. Int Rev Immunol 37(1):57–68. https://doi.org/10.1080/08830185.2017.1357719

Article  PubMed  Google Scholar 

Vijay N, Morse BL, Morris ME (2015) A novel monocarboxylate transporter inhibitor as a potential treatment strategy for γ-hydroxybutyric acid overdose. Pharm Res 32(6):1894. https://doi.org/10.1007/S11095-014-1583-0

CAS  Article  PubMed  Google Scholar 

Kekuda R, Manoharan P, Baseler W, Sundaram U (2013) Monocarboxylate 4 mediated butyrate transport in a rat intestinal epithelial cell line. Dig Dis Sci 58(3):660–667. https://doi.org/10.1007/S10620-012-2407-X

CAS  Article  PubMed  Google Scholar 

Carloni S et al (2021) Identification of a choroid plexus vascular barrier closing during intestinal inflammation. Science 1979:439–448. https://doi.org/10.1126/science.abc6108

Article  Google Scholar 

O’Connor KM, Lucking EF, Cryan JF, O’Halloran KD (2020) Bugs, breathing and blood pressure: microbiota–gut–brain axis signalling in cardiorespiratory control in health and disease. J Physiol 598(19):4159–4179. https://doi.org/10.1113/JP280279

CAS  Article  PubMed  Google Scholar 

Durgan DJ, Lee J, McCullough LD, Bryan RM (2019) Examining the role of the microbiota-gut-brain axis in stroke. Stroke 50(8):2270–2277. https://doi.org/10.1161/STROKEAHA.119.025140

Article  PubMed  PubMed Central  Google Scholar 

Sherman MP, Zaghouani H, Niklas V (2015) Gut microbiota, the immune system, and diet influence the neonatal gut-brain axis. Pediatr Res 77(1–2):127–135. https://doi.org/10.1038/PR.2014.161

Article  PubMed  Google Scholar 

Dalile B, van Oudenhove L, Vervliet B, Verbeke K (2019) The role of short-chain fatty acids in microbiota-gut-brain communication. Nat Rev Gastroenterol Hepatol 16(8):461–478. https://doi.org/10.1038/S41575-019-0157-3

Article  PubMed  Google Scholar 

Fung TC, Olson CA, Hsiao EY (2017) Interactions between the microbiota, immune and nervous systems in health and disease. Nat Neurosci 20(2):145–155. https://doi.org/10.1038/NN.4476

CAS  Article  PubMed  PubMed Central  Google Scholar 

Borre YE, O’Keeffe GW, Clarke G, Stanton C, Dinan TG, Cryan JF (2014) Microbiota and neurodevelopmental windows: implications for brain disorders. Trends Mol Med 20(9):509–518. https://doi.org/10.1016/J.MOLMED.2014.05.002

Article  PubMed  Google Scholar 

Silva YP, Bernardi A, Frozza RL (2020) The role of short-chain fatty acids from gut microbiota in gut-brain communication. Front Endocrinol 11:25. https://doi.org/10.3389/FENDO.2020.00025/BIBTEX

Article  Google Scholar 

Aswendt M et al (2021) The gut microbiota modulates brain network connectivity under physiological conditions and after acute brain ischemia. iScience 24(10). https://doi.org/10.1016/j.isci.2021.103095

Abdel-Haq R, Schlachetzki JCM, Glass CK, Mazmanian SK (2019) Microbiome–microglia connections via the gut–brain axis. J Exp Med 216(1):41–59. https://doi.org/10.1084/JEM.20180794

CAS  Article  PubMed  PubMed Central  Google Scholar 

Baruch K et al (2014) Aging-induced type I interferon response at the choroid plexus negatively affects brain function. Science (1979) 346(6205):89–93. https://doi.org/10.1126/science.1252945

CAS  Article  Google Scholar 

Croese T, Castellani G, Schwartz M (2021) Immune cell compartmentalization for brain surveillance and protection. Nat Immunol 22:1083–1092. https://doi.org/10.1038/s41590-021-00994-2

CAS  Article  PubMed  Google Scholar 

Kunis G et al (2013) IFN-γ-dependent activation of the brain’s choroid plexus for CNS immune surveillance and repair. Brain 136(11):3427–3440. https://doi.org/10.1093/BRAIN/AWT259

Article  PubMed  Google Scholar 

Schwartz M, Baruch K (2014) The resolution of neuroinflammation in neurodegeneration: leukocyte recruitment via the choroid plexus. EMBO J 33(1):7. https://doi.org/10.1002/EMBJ.201386609

CAS  Article  PubMed  Google Scholar 

Baruch K et al (2013) CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain aging. Proc Natl Acad Sci U S A 110(6):2264–2269. https://doi.org/10.1073/PNAS.1211270110/SUPPL_FILE/PNAS.201211270SI.PDF

CAS  Article  PubMed  PubMed Central  Google Scholar 

Clarke G, Quigley EMM, Cryan JF, Dinan TG (2009) Irritable bowel syndrome: towards biomarker identification. Trends Mol Med 15(10):478–489. https://doi.org/10.1016/J.MOLMED.2009.08.001

CAS  Article  PubMed  Google Scholar 

Carding S, Verbeke K, Vipond DT, Corfe BM, Owen LJ (2015) Dysbiosis of the gut microbiota in disease. Microb Ecol Health Dis 26(0). https://doi.org/10.3402/MEHD.V26.26191

Martin CR, Osadchiy V, Kalani A, Mayer EA (2018) The brain-gut-microbiome axis. Cell Mol Gastroenterol Hepatol 6(2):133–148. https://doi.org/10.1016/J.JCMGH.2018.04.003

Article  PubMed  PubMed Central  Google Scholar 

Rhee SH, Pothoulakis C, Mayer EA (2009) Principles and clinical implications of the brain-gut-enteric microbiota axis. Nat Rev Gastroenterol Hepatol 6(5):306–314. https://doi.org/10.1038/NRGASTRO.2009.35

CAS  Article  PubMed  Google Scholar 

Mayer EA (2011) Gut feelings: the emerging biology of gut-brain communication. Nat Rev Neurosci 12(8):453–466. https://doi.org/10.1038/NRN3071

CAS  Article  PubMed  Google Scholar 

Yang T et al (2015) Gut dysbiosis is linked to hypertension. Hypertension 65(6):1331–1340. https://doi.org/10.1161/HYPERTENSIONAHA.115.05315

CAS  Article  PubMed  Google Scholar 

Chow J, Lee SM, Shen Y, Khosravi A, Mazmanian SK (2010) Host-bacterial symbiosis in health and disease. Adv Immunol 107(C):243–274. https://doi.org/10.1016/B978-0-12-381300-8.00008-3

CAS  Article  PubMed  PubMed Central  Google Scholar 

Yang T, Zubcevic J (2017) Gut-brain axis in regulation of blood pressure. Front Physiol 8(OCT). https://doi.org/10.3389/FPHYS.2017.00845/FULL

Banks WA (2006) The blood-brain barrier as a regulatory interface in the gut-brain axes. Physiol Behav 89(4):472–476. https://doi.org/10.1016/J.PHYSBEH.2006.07.004

CAS  Article  PubMed  Google Scholar 

Wekerle H (2017) Brain autoimmunity and intestinal microbiota: 100 trillion game changers. Trends Immunol 38(7):483–497. https://doi.org/10.1016/J.IT.2017.03.008

CAS  Article  PubMed  Google Scholar 

Cryan JF, Dinan TG (2012) Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci 13(10):701–712. https://doi.org/10.1038/NRN3346

CAS  Article  PubMed  Google Scholar 

Günther C, Rothhammer V, Karow M, Neurath M, Winner B (2021) The gut-brain axis in inflammatory bowel disease—current and future perspectives. Int J Mol Sci 22(16):8870. https://doi.org/10.3390/IJMS22168870

Article  PubMed  PubMed Central  Google Scholar 

Sampson TR et al (2016) Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson’s disease. Cell 167(6). https://doi.org/10.1016/J.CELL.2016.11.018

Wu SC, Cao ZS, Chang KM, Juang JL (2017) Intestinal microbial dysbiosis aggravates the progression of Alzheimer’s disease in Drosophila. Nat Commun 8(1):1–9. https://doi.org/10.1038/s41467-017-00040-6

CAS  Article  Google Scholar 

Rothhammer V et al (2018) Microglial control of astrocytes in response to microbial metabolites. Nature 557(7707):724–728. https://doi.org/10.1038/S41586-018-0119-X

CAS  Article  PubMed  PubMed Central  Google Scholar 

Berer K et al (2011) Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature 479(7374):538–541. https://doi.org/10.1038/NATURE10554

CAS  Article  PubMed  Google Scholar 

Vuong HE, Hsiao EY (2017) Emerging roles for the gut microbiome in autism spectrum disorder. Biol Psychiatry 81(5):411–423. https://doi.org/10.1016/J.BIOPSYCH.2016.08.024

Article  PubMed  Google Scholar 

Mehrian-Shai R, Reichardt JKV, Harris CC, Toren A (2019) The gut-brain axis, paving the way to brain cancer. Trends Cancer 5(4):200–207. https://doi.org/10.1016/J.TRECAN.2019.02.008

CAS  Article  PubMed  PubMed Central  Google Scholar 

Bhattarai Y (2018) Microbiota-gut-brain axis: interaction of gut microbes and their metabolites with host epithelial barriers. Neurogastroenterol Motil 30(6):e13366. https://doi.org/10.1111/NMO.13366

CAS  Article  PubMed  Google Scholar 

Rescigno M (2017) The microbiota revolution: excitement and caution. Eur J Immunol 47(9):1406–1413. https://doi.org/10.1002/EJI.201646576

CAS  Article  PubMed  Google Scholar 

Johansson MEV, Hansson GC (2016) Immunological aspects of intestinal mucus and mucins. Nat Rev Immunol 16(10):639–649. https://doi.org/10.1038/NRI.2016.88

CAS  Article  PubMed  PubMed Central  Google Scholar 

Schroeder BO (2019) Fight them or feed them: how the intestinal mucus layer manages the gut microbiota. Gastroenterol Rep (Oxf) 7(1):3–12. https://doi.org/10.1093/GASTRO/GOY052

Article  Google Scholar 

Buckley A, Turner JR (2018) Cell biology of tight junction barrier regulation and mucosal disease. Cold Spring Harb Perspect Biol 10(1):a029314.

留言 (0)

沒有登入
gif