The effects of exercise programs on cognition, activities of daily living, and neuropsychiatric symptoms in community-dwelling people with dementia—a systematic review

World Health Organization. Global status report on the public health response to dementia. 2021.

Google Scholar 

National Collaborating Centre for Mental Health. Dementia: supporting people with dementia and their carers in health and social care. 2011.

Google Scholar 

Deuschl G, Maier W. S3-Leitlinie demenzen. Deutsche Gesellschaft für Neurologie, Hrsg. Leitlinien für Diagnostik und Therapie in der Neurologie, 2016:33. https://dgn.org/leitlinien/leitlinie-diagnose-und-therapievon-demenzen-2016/. Accessed 14 July 2022.

Kouloutbani K, Karteroliotis K, Politis A. The effect of physical activity on dementia. Psychiatriki. 2019;30(2):142–55.

CAS  PubMed  Article  Google Scholar 

Cass SP. Alzheimer’s disease and exercise: a literature review. Curr Sports Med Rep. 2017;16(1):19–22.

PubMed  Article  Google Scholar 

Du Z, Li Y, Li J, Zhou C, Li F, Yang X. Physical activity can improve cognition in patients with Alzheimer’s disease: a systematic review and meta-analysis of randomized controlled trials. Clin Interv Aging. 2018;13:1593.

PubMed  PubMed Central  Article  Google Scholar 

Song D, Yu DSF. Effects of a moderate-intensity aerobic exercise programme on the cognitive function and quality of life of community-dwelling elderly people with mild cognitive impairment: a randomised controlled trial. Int J Nurs Stud. 2019;93:97–105.

PubMed  Article  Google Scholar 

Morris JK, Vidoni ED, Johnson DK, Van Sciver A, Mahnken JD, Honea RA, et al. Aerobic exercise for Alzheimer’s disease: a randomized controlled pilot trial. PLoS ONE. 2017;12(2): e0170547.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Bürge E, Berchtold A, Maupetit C, Bourquin NM, von Gunten A, Ducraux D, et al. Does physical exercise improve ADL capacities in people over 65 years with moderate or severe dementia hospitalized in an acute psychiatric setting? A multisite randomized clinical trial. Int Psychogeriatr. 2017;29(2):323–32.

PubMed  Article  Google Scholar 

Toots A, Littbrand H, Boström G, Hörnsten C, Holmberg H, Lundin-Olsson L, et al. Effects of exercise on cognitive function in older people with dementia: a randomized controlled trial. J Alzheimers Dis. 2017;60(1):323–32.

PubMed  PubMed Central  Article  Google Scholar 

Sanders LMJ, Hortobágyi T, Karssemeijer EGA, Van der Zee EA, Scherder EJA, van Heuvelen MJG. Effects of low- and high-intensity physical exercise on physical and cognitive function in older persons with dementia: a randomized controlled trial. Alzheimers Res Ther. 2020;12(1):28.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Forbes D, Forbes SC, Blake CM, Thiessen EJ, Forbes S. Exercise programs for people with dementia. Cochrane Database Syst Rev. 2015;4. Art. No.:CD006489. https://doi.org/10.1002/14651858.CD006489.pub4. Accessed 14 July 2022.

Ströhle A, Schmidt DK, Schultz F, Fricke N, Staden T, Hellweg R, et al. Drug and exercise treatment of Alzheimer disease and mild cognitive impairment: a systematic review and meta-analysis of effects on cognition in randomized controlled trials. Am J Geriatr Psychiatry. 2015;23(12):1234–49.

PubMed  Article  Google Scholar 

Huang X, Zhao X, Li B, Cai Y, Zhang S, Wan Q, et al. Comparative efficacy of various exercise interventions on cognitive function in patients with mild cognitive impairment or dementia: a systematic review and network meta-analysis. J Sport Health Sci. 2022;11(2):212–23.

PubMed  Article  Google Scholar 

Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339: b2535.

PubMed  PubMed Central  Article  Google Scholar 

Wimo A, Gauthier S, Prince M. Global estimates of informal care. London: Alzheimer’s Disease International (ADI); 2018.

Google Scholar 

World Health Organization. Dementia: a public health priority: World Health Organization. 2012.

Google Scholar 

Sterne JA, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898.

PubMed  Article  Google Scholar 

Dimitriou T-D, Verykouki E, Papatriantafyllou J, Konsta A, Kazis D, Tsolaki M. Non-Pharmacological interventions for the anxiety in patients with dementia. a cross-over randomised controlled trial. Behav Brain Res. 2020;390:112617.

PubMed  Article  Google Scholar 

Barha CK, Hsiung G-YR, Best JR, Davis JC, Eng JJ, Jacova C, et al. Sex difference in aerobic exercise efficacy to improve cognition in older adults with vascular cognitive impairment: secondary analysis of a randomized controlled trial. J Alzheimer’s Dis. 2017;60(4):1397–410.

CAS  Article  Google Scholar 

Goldberg SE, Van Der Wardt V, Brand A, Burgon C, Bajwa R, Hoare Z, et al. Promoting activity, Independence and stability in early dementia (PrAISED): a, multisite, randomised controlled, feasibility trial. BMC Geriatr. 2019;19(1):1–12.

Article  Google Scholar 

Vidoni ED, Perales J, Alshehri M, Giles AM, Siengsukon CF, Burns JM. Aerobic exercise sustains performance of instrumental activities of daily living in early-stage Alzheimer’s disease (2001). J Geriatri Phys Ther. 2019;42(3):E129.

Article  Google Scholar 

van Santen J, Dröes R-M, Twisk JW, Henkemans OAB, van Straten A, Meiland FJ. Effects of exergaming on cognitive and social functioning of people with dementia: a randomized controlled trial. J Am Med Dir Assoc. 2020;21(12):1958–67.

PubMed  Article  Google Scholar 

Pires Camargo Novelli MM, Machado SC, Balestra de Lima G, Cantatore L, Pereira de Sena B, Rodrigues RS, et al. P3‐362: the Brazilian version of Tailored Activity Program (Tap‐BR) to manage neuropsychiatric behaviors in persons with dementia and reduce caregiver burden in Brazil: a randomized pilot study. Alzheimer’s & Dementia. 2016;12:P988-P.

Article  Google Scholar 

Kim M-J, Han C-W, Min K-Y, Cho C-Y, Lee C-W, Ogawa Y, et al. Physical exercise with multicomponent cognitive intervention for older adults with Alzheimer’s disease: a 6-month randomized controlled trial. Dementia Geriatri Cogn Disord Extra. 2016;6(2):222–32.

Article  Google Scholar 

de Oliveira AM, Radanovic M, de Homem Mello PC, Buchain PC, Dias Vizzotto A, Harder J, et al. An intervention to reduce neuropsychiatric symptoms and caregiver burden in dementia: preliminary results from a randomized trial of the tailored activity program–outpatient version. Int J Geriatr Psychiatr. 2019;34(9):1301–7.

Article  Google Scholar 

Dawson N, Judge KS, Gerhart H. Improved functional performance in individuals with dementia after a moderate-intensity home-based exercise program: a randomized controlled trial. J Geriatr Phys Ther. 2019;42(1):18–27.

PubMed  Article  Google Scholar 

Gbiri CAO, Amusa BF. Progressive task-oriented circuit training for cognition, physical functioning and societal participation in individuals with dementia. Physiother Res Int. 2020;25(4): e1866.

PubMed  Article  Google Scholar 

Khan I, Petrou S, Khan K, Mistry D, Lall R, Sheehan B, et al. Does structured exercise improve cognitive impairment in people with mild to moderate dementia? a cost-effectiveness analysis from a confirmatory randomised controlled trial: the dementia and physical activity (DAPA) trial. PharmacoEconomics-open. 2019;3(2):215–27.

PubMed  Article  Google Scholar 

Charras K, Mabire J-B, Bouaziz N, Deschamps P, Froget B, de Malherbe A, et al. Dance intervention for people with dementia: lessons learned from a small-sample crossover explorative study. Arts Psychother. 2020;70: 101676.

Article  Google Scholar 

Sobol NA, Dall CH, Høgh P, Hoffmann K, Frederiksen KS, Vogel A, et al. Change in fitness and the relation to change in cognition and neuropsychiatric symptoms after aerobic exercise in patients with mild Alzheimer’s disease. J Alzheimer’s Dis. 2018;65(1):137–45.

CAS  Article  Google Scholar 

Sanders L, Hortobágyi T, Karssemeijer E, Van der Zee E, Scherder E, Van Heuvelen M. Effects of low-and high-intensity physical exercise on physical and cognitive function in older persons with dementia: a randomized controlled trial. Alzheimer’s Res Ther. 2020;12(1):1–15.

Article  CAS  Google Scholar 

Huang N, Li W, Rong X, Champ M, Wei L, Li M, et al. Effects of a modified Tai Chi program on older people with mild dementia: a randomized controlled trial. J Alzheimer’s Dis. 2019;72(3):947–56.

Article  Google Scholar 

Fleiner T, Dauth H, Zijlstra W, Haussermann P. A structured physical exercise program reduces professional caregiver’s burden caused by neuropsychiatric symptoms in acute dementia care: randomized controlled trial results. J Alzheimer’s Dis. 2020;74(2):429–33.

Article  Google Scholar 

Enette L, Vogel T, Merle S, Valard-Guiguet A-G, Ozier-Lafontaine N, Neviere R, et al. Effect of 9 weeks continuous vs interval aerobic training on plasma BDNF levels, aerobic fitness, cognitive capacity and quality of life among seniors with mild to moderate Alzheimer’s disease: a randomized controlled trial. Eur Rev Aging Phys Act. 2020;17(1):1–16.

Article  Google Scholar 

Bossers WJ, van der Woude LH, Boersma F, Hortobágyi T, Scherder EJ, van Heuvelen MJ. Comparison of effect of two exercise programs on activities of daily living in individuals with dementia: a 9-week randomized, controlled trial. J Am Geriatr Soc. 2016;64(6):1258–66.

PubMed  Article  Google Scholar 

Hoffmann K, Sobol NA, Frederiksen KS, Beyer N, Vogel A, Vestergaard K, et al. Moderate-to-high intensity physical exercise in patients with Alzheimer’s disease: a randomized controlled trial. J Alzheimers Dis. 2016;50(2):443–53.

PubMed  Article  Google Scholar 

Park J, Tolea MI, Sherman D, Rosenfeld A, Arcay V, Lopes Y, et al. Feasibility of conducting nonpharmacological interventions to manage dementia symptoms in community-dwelling older adults: a cluster randomized controlled trial. Am J Alzheimers Dis Other Demen. 2020;35:1533317519872635.

PubMed  Google Scholar 

Karssemeijer EGA, Aaronson JA, Bossers WJR, Donders R, Olde Rikkert MGM, Kessels RPC. The quest for synergy between physical exercise and cognitive stimulation via exergaming in people with dementia: a randomized controlled trial. Alzheimers Res Ther. 2019;11(1):3.

PubMed  PubMed Central  Article  Google Scholar 

Yu F, Vock DM, Zhang L, Salisbury D, Nelson NW, Chow LS, et al. Cognitive effects of aerobic exercise in Alzheimer’s disease: a pilot randomized controlled trial. J Alzheimers Dis. 2021;80(1):233–44.

CAS  PubMed  PubMed Central  Article  Google Scholar 

de Oliveira Silva F, Ferreira JV, Placido J, Sant’Anna P, Araujo J, Marinho V, et al. Three months of multimodal training contributes to mobility and executive function in elderly individuals with mild cognitive impairment, but not in those with Alzheimer’s disease: a randomized controlled trial. Maturitas. 2019;126:28–33.

PubMed  Article  Google Scholar 

Lamb SE, Sheehan B, Atherton N, Nichols V, Collins H, Mistry D, et al. Dementia And Physical Activity (DAPA) trial of moderate to high intensity exercise training for people with dementia: randomised controlled trial. BMJ. 2018;361:k1675 ((no pagination)).

PubMed  PubMed Central  Article  Google Scholar 

Ohman H, Savikko N, Strandberg TE, Kautiainen H, Raivio MM, Laakkonen ML, et al. Effects of exercise on cognition: the finnish alzheimer disease exercise trial: a randomized, controlled trial. J Am Geriatr Soc. 2016;64(4):731–8.

PubMed  Article  Google Scholar 

Öhman H, Savikko NRN, Strandberg TE, Kautiainen H, Raivio MM, Laakkonen ML, et al. Effects of frequent and long-term exercise on neuropsychiatric symptoms in patients with Alzheimer’s disease – secondary analyses of a randomized, controlled trial (FINALEX). Eur Geriatr Med. 2017;8(2):153–

留言 (0)

沒有登入
gif