Rizvi S, Khan SA, Hallemeier CL, Kelley RK, Gores GJ. Cholangiocarcinoma—evolving concepts and therapeutic strategies. Nat Rev Clin Oncol. 2018;15:95–111.
CAS PubMed Article Google Scholar
Valle J, Wasan H, Palmer DH, Cunningham D, Anthoney A, Maraveyas A, et al. Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. N Engl J Med. 2010;362:1273–81.
CAS PubMed Article Google Scholar
Khan SA, Genus T, Morement H, Murphy A, Rous B, Tataru D. Global trends in mortality from intrahepatic and extrahepatic cholangiocarcinoma. J Hepatol. 2019;71:1261–2.
Rizvi S, Borad MJ, Patel T, Gores GJ. Cholangiocarcinoma: molecular pathways and therapeutic opportunities. Semin Liver Dis. 2014;34:456–64.
CAS PubMed PubMed Central Article Google Scholar
Thompson MA, Moon E, Kim UJ, Xu J, Siciliano MJ, Weinshilboum RM. Human indolethylamine N-methyltransferase: cDNA cloning and expression, gene cloning, and chromosomal localization. Genomics 1999;61:285–97.
CAS PubMed Article Google Scholar
Aksoy S, Szumlanski CL, Weinshilboum RM. Human liver nicotinamide N-methyltransferase cDNA cloning, expression, and biochemical characterization. J Biol Chem. 1994;269:14835–40.
CAS PubMed Article Google Scholar
Pissios P. Nicotinamide N-methyltransferase: more than a vitamin B3 clearance enzyme. Trends Endocrinol Metab. 2017;28:340–53.
CAS PubMed PubMed Central Article Google Scholar
Schmeisser K, Mansfeld J, Kuhlow D, Weimer S, Priebe S, Heiland I, et al. Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide. Nat Chem Biol. 2013;9:693–700.
CAS PubMed PubMed Central Article Google Scholar
Xie X, Yu H, Wang Y, Zhou Y, Li G, Ruan Z, et al. Nicotinamide N-methyltransferase enhances the capacity of tumorigenesis associated with the promotion of cell cycle progression in human colorectal cancer cells. Arch Biochem Biophys. 2014;564:52–66.
CAS PubMed Article Google Scholar
Stefatić D, Riederer M, Balić M, Dandachi N, Stanzer S, Janesch B, et al. Optimization of diagnostic ELISA-based tests for the detection of auto-antibodies against tumor antigens in human serum. Bosn J Basic Med Sci. 2008;8:245–50.
PubMed PubMed Central Article Google Scholar
Rizvi S, Gores GJ. Pathogenesis, diagnosis, and management of cholangiocarcinoma. Gastroenterology 2013;145:1215–29.
CAS PubMed Article Google Scholar
Clapéron A, Mergey M, Nguyen Ho-Bouldoires TH, Vignjevic D, Wendum D, Chrétien Y, et al. EGF/EGFR axis contributes to the progression of cholangiocarcinoma through the induction of an epithelial-mesenchymal transition. J Hepatol. 2014;61:325–32.
PubMed Article CAS Google Scholar
Jensen LH. Clinical aspects and perspectives of erlotinib in the treatment of patients with biliary tract cancer. Expert Opin Investig Drugs. 2016;25:359–65.
CAS PubMed Article Google Scholar
Cui Y, Yang D, Wang W, Zhang L, Liu H, Ma S, et al. Nicotinamide N-methyltransferase decreases 5-fluorouracil sensitivity in human esophageal squamous cell carcinoma through metabolic reprogramming and promoting the Warburg effect. Mol Carcinog. 2020;59:940–54.
CAS PubMed Article Google Scholar
You Z, Liu Y, Liu X. Nicotinamide N-methyltransferase enhances the progression of prostate cancer by stabilizing sirtuin 1. Oncol Lett. 2018;15:9195–201.
PubMed PubMed Central Google Scholar
Mistry RJ, Klamt F, Ramsden DB, Parsons RB. Nicotinamide N-methyltransferase expression in SH-SY5Y human neuroblastoma cells decreases oxidative stress. J Biochem Mol Toxicol. 2020;34:e22439.
CAS PubMed Article Google Scholar
Bach DH, Kim D, Bae SY, Kim WK, Hong JY, Lee HJ, et al. Targeting nicotinamide N-methyltransferase and miR-449a in EGFR-TKI-resistant non-small-cell lung cancer cells. Mol Ther Nucleic Acids. 2018;11:455–67.
CAS PubMed PubMed Central Article Google Scholar
Liang L, Zeng M, Pan H, Liu H, He Y. Nicotinamide N-methyltransferase promotes epithelial-mesenchymal transition in gastric cancer cells by activating transforming growth factor-β1 expression. Oncol Lett. 2018;15:4592–8.
PubMed PubMed Central Google Scholar
Eckert MA, Coscia F, Chryplewicz A, Chang JW, Hernandez KM, et al. Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts. Nature 2019;569:723–8.
CAS PubMed PubMed Central Article Google Scholar
Zhang J, Wang Y, Li G, Yu H, Xie X. Down-regulation of nicotinamide N-methyltransferase Induces apoptosis in human breast cancer cells via the mitochondria-mediated pathway. PLoS ONE. 2014;9:e89202.
PubMed PubMed Central Article CAS Google Scholar
Wang C, Dong L, Li X, Li Y, Zhang B, Wu H, et al. The PGC1α/NRF1-MPC1 axis suppresses tumor progression and enhances the sensitivity to sorafenib/doxorubicin treatment in hepatocellular carcinoma. Free Radic Biol Med. 2021;163:141–52.
CAS PubMed Article Google Scholar
Li D, Wang C, Ma P, Yu Q, Gu M, Dong L, et al. PGC1α promotes cholangiocarcinoma metastasis by upregulating PDHA1 and MPC1 expression to reverse the Warburg effect. Cell Death Dis. 2018;9:466.
Yang W, Xia Y, Ji H, Zheng Y, Liang J, Huang W, et al. Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation. Nature 2011;480:118–22.
CAS PubMed PubMed Central Article Google Scholar
De Rosa V, Iommelli F, Monti M, Fonti R, Votta G, Stoppelli MP, et al. Reversal of Warburg effect and reactivation of oxidative phosphorylation by differential inhibition of EGFR signaling pathways in non-small cell lung cancer. Clin Cancer Res. 2015;21:5110–20.
PubMed Article CAS Google Scholar
Ulanovskaya OA, Zuhl AM, Cravatt BF. NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink. Nat Chem Biol. 2013;9:300–6.
CAS PubMed PubMed Central Article Google Scholar
Hong S, Zhai B, Pissios P. Nicotinamide N-methyltransferase interacts with enzymes of the methionine cycle and regulates methyl donor metabolism. Biochemistry 2018;57:5775–9.
CAS PubMed Article Google Scholar
Fan J, Krautkramer KA, Feldman JL, Denu JM. Metabolic regulation of histone post-translational modifications. ACS Chem Biol. 2015;10:95–108.
CAS PubMed PubMed Central Article Google Scholar
Schwartz L, Seyfried T, Alfarouk KO, Da Veiga Moreira J, Fais S. Out of Warburg effect: an effective cancer treatment targeting the tumor specific metabolism and dysregulated pH. Semin Cancer Biol. 2017;43:134–8.
CAS PubMed Article Google Scholar
Zhang Y, Lu Z, Zeng W, Zhao J, Zhou X. Two sides of NNMT in alcoholic and nonalcoholic fatty liver development. J Hepatol. 2021;74:1250–3.
CAS PubMed Article Google Scholar
Brachs S, Polack J, Brachs M, Jahn-Hofmann K, Elvert R, Pfenninger A, et al. Genetic nicotinamide N-methyltransferase (Nnmt) deficiency in male mice improves insulin sensitivity in diet-induced obesity but does not affect glucose tolerance. Diabetes 2019;68:527–42.
CAS PubMed Article Google Scholar
Ström K, Morales-Alamo D, Ottosson F, Edlund A, Hjort L, Jörgensen SW, et al. N1-methylnicotinamide is a signaling molecule produced in skeletal muscle coordinating energy metabolism. Sci Rep. 2018;8:3016.
PubMed PubMed Central Article CAS Google Scholar
Li J, You S, Zhang S, Hu Q, Wang F, Chi X, et al. Elevated N-methyltransferase expression induced by hepatic stellate cells contributes to the metastasis of hepatocellular carcinoma via regulation of the CD44v3 isoform. Mol Oncol. 2019;13:1993–2009.
CAS PubMed PubMed Central Article Google Scholar
Pellat A, Vaquero J, Fouassier L. Role of ErbB/HER family of receptor tyrosine kinases in cholangiocyte biology. Hepatology 2018;67:762–73.
CAS PubMed Article Google Scholar
Vaquero J, Lobe C, Tahraoui S, Clapéron A, Mergey M, Merabtene F, et al. The IGF2/IR/IGF1R pathway in tumor cells and myofibroblasts mediates resistance to EGFR inhibition in cholangiocarcinoma. Clin Cancer Res. 2018;24:4282–96.
CAS PubMed Article Google Scholar
Tiemin P, Fanzheng M, Peng X, Jihua H, Ruipeng S, Yaliang L, et al. MUC13 promotes intrahepatic cholangiocarcinoma progression via EGFR/PI3K/AKT pathways. J Hepatol. 2020;72:761–73.
PubMed Article CAS Google Scholar
Schmitz KJ, Lang H, Wohlschlaeger J, Sotiropoulos GC, Reis H, Schmid KW, et al. AKT and ERK1/2 signaling in intrahepatic cholangiocarcinoma. World J Gastroenterol. 2007;13:6470–7.
CAS PubMed PubMed Central Article Google Scholar
Shepherd FA, Rodrigues Pereira J, Ciuleanu T, Tan EH, Hirsh V, Thongprasert S, et al. Erlotinib in previously treated non-small-cell lung cancer. N. Engl J Med. 2005;353:123–32.
留言 (0)