Kulik L, El-Serag HB. Epidemiology and management of hepatocellular carcinoma. Gastroenterology. 2019;156:477–91.
Llovet JM, Zucman-Rossi J, Pikarsky E, Sangro B, Schwartz M, Sherman M, et al. Hepatocellular carcinoma. Nat Rev Dis Prim. 2016;2:16018.
Llovet JM, Montal R, Sia D, Finn RS. Molecular therapies and precision medicine for hepatocellular carcinoma. Nat Rev Clin Oncol. 2018;15:599–616.
Nguyen LK, Kholodenko BN, von Kriegsheim A. Rac1 and RhoA: Networks, loops and bistability. Small GTPases. 2018;9:316–21.
CAS PubMed Article Google Scholar
Remorino A, De Beco S, Cayrac F, Di Federico F, Cornilleau G, Gautreau A, et al. Gradients of Rac1 nanoclusters support spatial patterns of Rac1 signaling. Cell Rep. 2017;21:1922–35.
CAS PubMed Article Google Scholar
Winge MC, Ohyama B, Dey CN, Boxer LM, Li W, Ehsani-Chimeh N, et al. RAC1 activation drives pathologic interactions between the epidermis and immune cells. J Clin Invest. 2016;126:2661–77.
PubMed PubMed Central Article Google Scholar
Acevedo A, Gonzalez-Billault C. Crosstalk between Rac1-mediated actin regulation and ROS production. Free Radic Biol Med. 2018;116:101–13.
CAS PubMed Article Google Scholar
Yang J, Qiu Q, Qian X, Yi J, Jiao Y, Yu M, et al. Long noncoding RNA LCAT1 functions as a ceRNA to regulate RAC1 function by sponging miR-4715-5p in lung cancer. Mol Cancer. 2019;18:171.
CAS PubMed PubMed Central Article Google Scholar
Zou T, Mao X, Yin J, Li X, Chen J, Zhu T, et al. Emerging roles of RAC1 in treating lung cancer patients. Clin Genet. 2017;91:520–8.
CAS PubMed Article Google Scholar
Bayo J, Fiore EJ, Dominguez LM, Cantero MJ, Ciarlantini MS, Malvicini M, et al. Bioinformatic analysis of RHO family of GTPases identifies RAC1 pharmacological inhibition as a new therapeutic strategy for hepatocellular carcinoma. Gut. 2021;70:1362–74.
CAS PubMed Article Google Scholar
Takenaka N, Nihata Y, Ueda S, Satoh T. In situ detection of the activation of Rac1 and RalA small GTPases in mouse adipocytes by immunofluorescent microscopy following in vivo and ex vivo insulin stimulation. Cell Signal. 2017;39:108–17.
CAS PubMed Article Google Scholar
Akula MK, Ibrahim MX, Ivarsson EG, Khan OM, Kumar IT, Erlandsson M, et al. Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions. Nat Commun. 2019;10:3975.
CAS PubMed PubMed Central Article Google Scholar
Lorente M, Garcia-Casas A, Salvador N, Martinez-Lopez A, Gabicagogeascoa E, Velasco G, et al. Inhibiting SUMO1-mediated SUMOylation induces autophagy-mediated cancer cell death and reduces tumour cell invasion via RAC1. 2019;132:jcs234120, 1–12.
Oberoi-Khanuja TK, Rajalingam K. Ubiquitination of Rac1 by inhibitors of apoptosis (IAPs). Methods Mol Biol. 2014;1120:43–54.
CAS PubMed Article Google Scholar
Oberoi TK, Dogan T, Hocking JC, Scholz RP, Mooz J, Anderson CL, et al. IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation. EMBO J. 2012;31:14–28.
CAS PubMed Article Google Scholar
Torrino S, Visvikis O, Doye A, Boyer L, Stefani C, Munro P, et al. The E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of active Rac1. Dev Cell. 2011;21:959–65.
CAS PubMed Article Google Scholar
Li T, Qin JJ, Yang X, Ji YX, Guo F, Cheng WL, et al. The ubiquitin E3 ligase TRAF6 exacerbates ischemic stroke by ubiquitinating and activating Rac1. J Neurosci. 2017;37:12123–40.
CAS PubMed PubMed Central Article Google Scholar
Frances D, Sharma N, Pofahl R, Maneck M, Behrendt K, Reuter K, et al. A role for Rac1 activity in malignant progression of sebaceous skin tumors. Oncogene 2015;34:5505–12.
CAS PubMed Article Google Scholar
McBeath R, Edwards RW, O’Hara BJ, Maltenfort MG, Parks SM, Steplewski A, et al. Tendinosis develops from age- and oxygen tension-dependent modulation of Rac1 activity. Aging Cell. 2019;18:e12934.
PubMed PubMed Central Article CAS Google Scholar
Marston DJ, Anderson KL, Swift MF, Rougie M, Page C, Hahn KM, et al. High Rac1 activity is functionally translated into cytosolic structures with unique nanoscale cytoskeletal architecture. Proc Natl Acad Sci USA. 2019;116:1267–72.
CAS PubMed PubMed Central Article Google Scholar
Cai C, Masumiya H, Weisleder N, Matsuda N, Nishi M, Hwang M, et al. MG53 nucleates assembly of cell membrane repair machinery. Nat Cell Biol. 2009;11:56–64.
CAS PubMed Article Google Scholar
Liu W, Wang G, Zhang C, Ding W, Cheng W, Luo Y, et al. MG53, A novel regulator of KChIP2 and Ito,f, plays a critical role in electrophysiological remodeling in cardiac hypertrophy. Circulation. 2019;139:2142–56.
CAS PubMed Article Google Scholar
Bian Z, Wang Q, Zhou X, Tan T, Park KH, Kramer HF, et al. Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function. Nat Commun. 2019;10:4659.
PubMed PubMed Central Article CAS Google Scholar
Wu HK, Zhang Y, Cao CM, Hu X, Fang M, Yao Y, et al. Glucose-sensitive myokine/cardiokine MG53 regulates systemic insulin response and metabolic homeostasis. Circulation. 2019;139:901–14.
CAS PubMed Article Google Scholar
Sermersheim M, Kenney AD, Lin PH, McMichael TM, Cai C, Gumpper K, et al. MG53 suppresses interferon-beta and inflammation via regulation of ryanodine receptor-mediated intracellular calcium signaling. Nat Commun. 2020;11:3624.
PubMed PubMed Central Article CAS Google Scholar
Yi JS, Park JS, Ham YM, Nguyen N, Lee NR, Hong J, et al. MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling. Nat Commun. 2013;4:2354.
Jaworska AM, Wlodarczyk NA, Mackiewicz A, Czerwinska P. The role of TRIM family proteins in the regulation of cancer stem cell self-renewal. Stem Cells. 2020;38:165–73.
CAS PubMed Article Google Scholar
Hatakeyama S. TRIM family proteins: roles in autophagy, immunity, and carcinogenesis. Trends Biochem Sci. 2017;42:297–311.
CAS PubMed Article Google Scholar
Song R, Peng W, Zhang Y, Lv F, Wu HK, Guo J, et al. Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders. Nature. 2013;494:375–9.
CAS PubMed Article Google Scholar
Lionarons DA, Hancock DC, Rana S, East P, Moore C, Murillo MM, et al. RAC1(P29S) induces a mesenchymal phenotypic switch via serum response factor to promote melanoma development and therapy resistance. Cancer Cell. 2019;36:68–83.
CAS PubMed PubMed Central Article Google Scholar
Jiang ZB, Ma BQ, Liu SG, Li J, Yang GM, Hou YB, et al. miR-365 regulates liver cancer stem cells via RAC1 pathway. Mol Carcinog. 2019;58:55–65.
CAS PubMed Article Google Scholar
Wei L, Lee D, Law CT, Zhang MS, Shen J, Chin DW, et al. Genome-wide CRISPR/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC. Nat Commun. 2019;10:4681.
PubMed PubMed Central Article CAS Google Scholar
Zhu YJ, Zheng B, Wang HY, Chen L. New knowledge of the mechanisms of sorafenib resistance in liver cancer. Acta Pharm Sin. 2017;38:614–22.
Li Q, Ren B, Gui Q, Zhao J, Wu M, Shen M, et al. Blocking MAPK/ERK pathway sensitizes hepatocellular carcinoma cells to temozolomide via downregulating MGMT expression. Ann Transl Med. 2020;8:1305.
CAS PubMed PubMed Central Article Google Scholar
Dietrich P, Koch A, Fritz V, Hartmann A, Bosserhoff AK, Hellerbrand C. Wild type Kirsten rat sarcoma is a novel microRNA-622-regulated therapeutic target for hepatocellular carcinoma and contributes to sorafenib resistance. Gut. 2018;67:1328–41.
CAS PubMed Article Google Scholar
Zhang Y, Li T, Guo P, Kang J, Wei Q, Jia X, et al. MiR-424-5p reversed epithelial-mesenchymal transition of anchorage-independent HCC cells by directly targeting ICAT and suppressed HCC progression. Sci Rep. 2014;4:6248.
CAS PubMed PubMed Central Article Google Scholar
Bao Z, Zhang L, Li L, Yan J, Pang Q, Sun Z, et al. Nepsilon-carboxymethyl-lysine negatively regulates foam cell migration via the Vav1/Rac1 pathway. J Immunol Res. 2020;2020:1906204.
PubMed PubMed Central Google Scholar
Navarro-Lerida I, Sanchez-Perales S, Calvo M, Rentero C, Zheng Y, Enrich C, et al. A palmitoylation switch mechanism regulates Rac1 function and membrane organization. EMBO J. 2012;31:534–51.
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