High glucose and palmitic acid induces neuronal senescence by NRSF/REST elevation and the subsequent mTOR-related autophagy suppression

Bloomgarden Z, Ning G. Diabetes and aging. J Diabetes. 2013;5(4):369–71.

Article  Google Scholar 

Deshpande AD, Harris-Hayes M, Schootman M. Epidemiology of diabetes and diabetes-related complications. Phys Ther. 2008;88(11):1254–64.

Article  Google Scholar 

Bucala R. Diabetes, aging, and their tissue complications. J Clin Invest. 2014;124(5):1887–8.

CAS  Article  Google Scholar 

Palmer AK, Gustafson B, Kirkland JL, Smith U. Cellular senescence: at the nexus between ageing and diabetes. Diabetologia. 2019;62(10):1835–41.

Article  Google Scholar 

Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, et al. Cellular senescence: defining a path forward. Cell. 2019;179(4):813–27.

CAS  Article  Google Scholar 

Tan FC, Hutchison ER, Eitan E, Mattson MP. Are there roles for brain cell senescence in aging and neurodegenerative disorders? Biogerontology. 2014;15(6):643–60.

CAS  Article  Google Scholar 

Munoz-Espin D, Serrano M. Cellular senescence: from physiology to pathology. Nat Rev Mol Cell Biol. 2014;15(7):482–96.

CAS  Article  Google Scholar 

Jurk D, Wang C, Miwa S, Maddick M, Korolchuk V, Tsolou A, et al. Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response. Aging Cell. 2012;11(6):996–1004.

CAS  Article  Google Scholar 

Palmer AK, Tchkonia T, LeBrasseur NK, Chini EN, Xu M, Kirkland JL. Cellular senescence in type 2 diabetes: a therapeutic opportunity. Diabetes. 2015;64(7):2289–98.

CAS  Article  Google Scholar 

Aguayo-Mazzucato C, Andle J, Lee TB Jr, Midha A, Talemal L, Chipashvili V, et al. Acceleration of beta cell aging determines diabetes and senolysis improves disease outcomes. Cell Metab. 2019;30(1):129-42 e4.

CAS  Article  Google Scholar 

Maeda M, Hayashi T, Mizuno N, Hattori Y, Kuzuya M. Intermittent high glucose implements stress-induced senescence in human vascular endothelial cells: role of superoxide production by NADPH oxidase. PLoS ONE. 2015;10(4): e0123169.

Article  Google Scholar 

Bury JJ, Chambers A, Heath PR, Ince PG, Shaw PJ, Matthews FE, et al. Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain. Acta Neuropathol Commun. 2021;9(1):5.

CAS  Article  Google Scholar 

Xiao-Die X, Xiao-Hong W, Cheng-Feng H, Zhong-Yu Y, Jian-Tao W, Hou-Guang Z, et al. Increased NRSF/REST in anterior cingulate cortex contributes to diabetes-related neuropathic pain. Biochem Bioph Res Commun. 2020;527(3):785–90.

Article  Google Scholar 

Hwang JY, Zukin RS. REST, a master transcriptional regulator in neurodegenerative disease. Curr Opin Neurobiol. 2018;48:193–200.

CAS  Article  Google Scholar 

Ishikawa S, Ishikawa F. Proteostasis failure and cellular senescence in long-term cultured postmitotic rat neurons. Aging Cell. 2020;19(1): e13071.

CAS  Article  Google Scholar 

Weichhart T. mTOR as regulator of lifespan, aging, and cellular senescence: a mini-review. Gerontology. 2018;64(2):127–34.

CAS  Article  Google Scholar 

Liu GY, Sabatini DM. mTOR at the nexus of nutrition, growth, ageing and disease. Nat Rev Mol Cell Biol. 2020;21(4):183–203.

CAS  Article  Google Scholar 

Cho E, Moon SM, Park BR, Kim DK, Lee BK, Kim CS. NRSF/REST regulates the mTOR signaling pathway in oral cancer cells. Oncol Rep. 2015;33(3):1459–64.

CAS  Article  Google Scholar 

Ogrodnik M, Miwa S, Tchkonia T, Tiniakos D, Wilson CL, Lahat A, et al. Cellular senescence drives age-dependent hepatic steatosis. Nat Commun. 2017;8:15691.

CAS  Article  Google Scholar 

Minamino T, Orimo M, Shimizu I, Kunieda T, Yokoyama M, Ito T, et al. A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat Med. 2009;15(9):1082–7.

CAS  Article  Google Scholar 

Verzola D, Gandolfo MT, Gaetani G, Ferraris A, Mangerini R, Ferrario F, et al. Accelerated senescence in the kidneys of patients with type 2 diabetic nephropathy. Am J Physiol-Renal. 2008;295(5):F1563–73.

CAS  Article  Google Scholar 

Korf ESC, White LR, Scheltens P, Launer LJ. Brain aging in very old men with type 2 diabetes—The Honolulu-Asia Aging Study. Diabetes Care. 2006;29(10):2268–74.

Article  Google Scholar 

Roriz JS, Sa-Roriz TM, Rosset I, Camozzato AL, Santos AC, Chaves MLF, et al. (Pre)diabetes, brain aging, and cognition. Bba-Mol Basis Dis. 2009;1792(5):432–43.

Article  Google Scholar 

Ogrodnik M, Zhu Y, Langhi LGP, Tchkonia T, Krüger P, Fielder E, et al. Obesity-induced cellular senescence drives anxiety and impairs neurogenesis. Cell Metab. 2019;29(5):1061-77.e8.

CAS  Article  Google Scholar 

Thibault O, Anderson KL, DeMoll C, Brewer LD, Landfield PW, Porter NM. Hippocampal calcium dysregulation at the nexus of diabetes and brain aging. Eur J Pharmacol. 2013;719(1–3):34–43.

CAS  Article  Google Scholar 

Kuo LJ, Yang LX. Gamma-H2AX - a novel biomarker for DNA double-strand breaks. In Vivo. 2008;22(3):305–9.

CAS  PubMed  Google Scholar 

Zhao Y, Zhu M, Yu Y, Qiu L, Zhang Y, He L, et al. Brain REST/NRSF is not only a silent repressor but also an active protector. Mol Neurobiol. 2017;54(1):541–50.

CAS  Article  Google Scholar 

Lepagnol-Bestel AM, Maussion G, Ramoz N, Moalic JM, Gorwood P, Simonneau M. Nrsf silencing induces molecular and subcellular changes linked to neuronal plasticity. NeuroReport. 2007;18(5):441–6.

CAS  Article  Google Scholar 

Singh SK, Kagalwala MN, Parker-Thornburg J, Adams H, Majumder S. REST maintains self-renewal and pluripotency of embryonic stem cells. Nature. 2008;453(7192):223-U11.

CAS  Article  Google Scholar 

Coulson JM. Transcriptional regulation: cancer, neurons and the REST. Curr Biol. 2005;15(17):R665–8.

CAS  Article  Google Scholar 

Song ZQ, Zhao DM, Zhao HJ, Yang LF. NRSF: an angel or a devil in neurogenesis and neurological diseases. J Mol Neurosci. 2015;56(1):131–44.

CAS  Article  Google Scholar 

Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, et al. REST and stress resistance in ageing and Alzheimer’s disease. Nature. 2014;507(7493):448–54.

CAS  Article  Google Scholar 

Zullo JM, Drake D, Aron L, O’Hern P, Dhamne SC, Davidsohn N, et al. Regulation of lifespan by neural excitation and REST. Nature. 2019;574(7778):359–64.

CAS  Article  Google Scholar 

Pogoda A, Chmielewska N, Maciejak P, Szyndler J. Transcriptional dysregulation in Huntington’s disease: the role in pathogenesis and potency for pharmacological targeting. Curr Med Chem. 2021;28(14):2783–806.

CAS  Article  Google Scholar 

Kawamura M, Sato S, Matsumoto G, Fukuda T, Shiba-Fukushima K, Noda S, et al. Loss of nuclear REST/NRSF in aged-dopaminergic neurons in Parkinson’s disease patients. Neurosci Lett. 2019;699:59–63.

CAS  Article  Google Scholar 

Fernandes V, Choudhary M, Kumar A, Singh SB. Proteotoxicity and mitochondrial dynamics in aging diabetic brain. Pharmacol Res. 2020;159: 104948.

CAS  Article  Google Scholar 

Kim YC, Guan KL. mTOR: a pharmacologic target for autophagy regulation. J Clin Invest. 2015;125(1):25–32.

Article  Google Scholar 

Thellung S, Corsaro A, Nizzari M, Barbieri F, Florio T. Autophagy activator drugs: a new opportunity in neuroprotection from misfolded protein toxicity. Int J Mol Sci. 2019;20(4):901.

CAS  Article  Google Scholar 

Choi YJ, Park YJ, Park JY, Jeong HO, Kim DH, Ha YM, et al. Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion. PLoS ONE. 2012. https://doi.org/10.1371/journal.pone.0043418.

Article  PubMed  PubMed Central  Google Scholar 

Rocchi A, Carminati E, De Fusco A, Kowalska JA, Floss T, Benfenati F. REST/NRSF deficiency impairs autophagy and leads to cellular senescence in neurons. Aging Cell. 2021;20(10): e13471.

CAS  Article  Google Scholar 

留言 (0)

沒有登入
gif