記住我
Dementia and Geriatric Cognitive Disorders
Renftle D.a,b· Becker S.a,c· Brockmann K.a,b· Gasser T.a,b· Michaelis K.a,b· Solbrig S.a,b· Sulzer P.a,b· Johnen A.d· Liepelt-Scarfone I.a,b,eaDepartment of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
bGerman Center for Neurodegenerative Diseases (DZNE), University of Tübingen, Tübingen, Germany
cDepartment of Psychology, University of Calgary, Calgary, AB, Canada
dClinic of Neurology with Translational Neurology, University Hospital Münster, Münster, Germany
eIB Hochschule für Gesundheit und Soziales, Stuttgart, Germany
Dement Geriatr Cogn Disord
Log in to MyKarger to check if you already have access to this content.
Buy FullText & PDF Unlimited re-access via MyKarger Unrestricted printing, no saving restrictions for personal use read more
CHF 38.00 *
EUR 35.00 *
USD 39.00 *
Buy a Karger Article Bundle (KAB) and profit from a discount!
If you would like to redeem your KAB credit, please log in.
Save over 20% compared to the individual article price. Access via DeepDyve Unlimited fulltext viewing Of this article Organize, annotate And mark up articles Printing And downloading restrictions apply Subscribe Access to all articles of the subscribed year(s) guaranteed for 5 years Unlimited re-access via Subscriber Login or MyKarger Unrestricted printing, no saving restrictions for personal use read more Select* The final prices may differ from the prices shown due to specifics of VAT rules.
Article / Publication DetailsFirst-Page Preview
Received: March 21, 2022
Accepted: June 16, 2022
Published online: July 18, 2022
Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 3
ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)
For additional information: https://www.karger.com/DEM
AbstractIntroduction: Ideomotor apraxia, a disorder of skilled movements affecting limbs and/or face, can be seen in patients with Parkinson’s disease (PD), yet tests of apraxia in PD are rare. The aim of this project was to evaluate the psychometric properties and validity of the Dementia Apraxia Test (DATE) in a PD sample. Methods: 118 PD patients were included. Besides DATE performance, motor and non-motor burden, cognition, and activity of daily living (ADL) function were assessed. Patients were classified as cognitively impaired (n = 41) or non-cognitively impaired (n = 77). Results: Interrater reliability of the DATE (sub-)scores between video ratings and on-site ratings by the investigator was good (0.81 ≤ rk ≤ 0.87). Items were mostly easy to perform, especially the buccofacial apraxia items, which had also low discriminatory power. DATE scores were associated with cognition and ADL function. DATE performance was confounded by motor impairment and patients’ age; however, when analysed for both cognitive groups separately, the correlation between DATE and motor performance was not significant. Discussion/Conclusion: The DATE seems to be an objective and predominantly valid apraxia screening tool for PD patients, with a few items needing revision. Due to the potential effect of motor impairment and age, standardized scores adjusting for these confounders are needed.
© 2022 S. Karger AG, Basel
References Heilman KM, Gonzalez Rothi LJ. Apraxia. In: Heilman KM, Valenstein E, editors. Clinical neuropsychology. Oxford, UK: Oxford University Press; 1993. p. 141–63. Platz T. Apraxia. In: Selzer ME, Clarke S, Cohen LG, Duncan PW, Gage FH, editors. Textbook of neural repair and rehabilitation: medical neurorehabilitation. New York, US: Cambridge University Press; 2006. De Renzi E, Motti F, Nichelli P. Imitating gestures. A quantitative approach to ideomotor apraxia. Arch Neurol. 1980;37(1):6–10. Chandra SR, Issac TG, Abbas MM. Apraxias in neurodegenerative dementias. Indian J Psychol Med. 2015;37(1):42–7. Ahmed S, Baker I, Thompson S, Husain M, Butler CR. Utility of testing for apraxia and associated features in dementia. J Neurol Neurosurg Psychiatry. 2016;87(11):1158–62. Zadikoff C, Lang AE. Apraxia in movement disorders. Brain. 2005;128(7):1480–97. Hödl AK, Hödl E, Otti DV, Herranhof B, Ille R, Bonelli RM. Ideomotor limb apraxia in Huntington’s disease. J Neurol. 2008;255(3):331–9. Hirtz D, Thurman DJ, Gwinn-Hardy K, Mohamed M, Chaudhuri AR, Zalutsky R. How common are the “common” neurologic disorders? Neurology. 2007;68(5):326–37. Barone P, Antonini A, Colosimo C, Marconi R, Morgante L, Avarello TP, et al. The PRIAMO study: a multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson’s disease. Mov Disord. 2009;24(11):1641–9. Titova N, Chaudhuri KR. Non-motor Parkinson disease: new concepts and personalised management. Med J Aust. 2018;208(9):404–9. Sharpe MH, Cermak SA, Sax DS. Motor planning in Parkinson patients. Neuropsychologia. 1983;21(5):455–62. Matt E, Foki T, Fischmeister F, Pirker W, Haubenberger D, Rath J, et al. Early dysfunctions of fronto-parietal praxis networks in Parkinson’s disease. Brain Imaging Behav. 2017;11(2):512–25. Goldenberg G, Wimmer A, Auff E, Schnaberth G. Impairment of motor planning in patients with Parkinson’s disease: evidence from ideomotor apraxia testing. J Neurol Neurosurg Psychiatry. 1986;49(11):1266–72. Uluduz D, Ertürk Ö, Kenangil G, Ozekmekçi S, Ertan S, Apaydin H, et al. Apraxia in Parkinson’s disease and multiple system atrophy. Eur J Neurol. 2010;17(3):413–8. Vanbellingen T, Lungu C, Lopez G, Baronti F, Müri R, Hallett M, et al. Short and valid assessment of apraxia in Parkinson’s disease. Parkinsonism Relat Disord. 2012;18(4):348–50. van Heugten CM, Dekker J, Deelman BG, Stehmann-Saris FC, Kinebanian A. A diagnostic test for apraxia in stroke patients: internal consistency and diagnostic value. Clin Neuropsychol. 1999;13(2):182–92. Johnen A, Frommeyer J, Modes F, Wiendl H, Duning T, Lohmann H. Dementia apraxia test (DATE): a brief tool to differentiate behavioral variant frontotemporal dementia from Alzheimer’s dementia based on apraxia profiles. J Alzheimers Dis. 2016;49(3):593–605. Becker S, Bäumer A, Maetzler W, Nussbaum S, Timmers M, Van Nueten L, et al. Assessment of cognitive-driven activity of daily living impairment in non-demented Parkinson’s patients. J Neuropsychol. 2020;14(1):69–84. Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry. 1992;55(3):181–4. Goetz CG, Tilley BC, Shaftman SR, Stebbins GT, Fahn S, Martinez-Martin P, et al. Movement disorder society-sponsored revision of the Unified Parkinson’s disease rating scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov Disord. 2008;23(15):2129–70. Pfeffer RI, Kurosaki TT, Harrah CHJ, Chance JM, Filos S. Measurement of functional activities in older adults in the community. J Gerontol. 1982;37(3):323–9. Storch A, Odin P, Trender-Gerhard I, Fuchs G, Reifschneider G, Ray Chaudhuri R, et al. Non-motor Symptoms Questionnaire und Scale für das idiopathische Parkinson-Syndrom. Nervenarzt. 2010;81(8):980–5. Hautzinger M, Keller F, Kühner C. Beck depressions-inventar revision (BDI II). Frankfurt, Germany: Pearson; 2009. Litvan I, Goldman JG, Tröster AI, Schmand BA, Weintraub D, Petersen RC, et al. Diagnostic criteria for mild cognitive impairment in Parkinson’s disease: movement disorder society task force guidelines. Mov Disord. 2012;27(3):349–56. Nasreddine ZS, Phillips NA, Bédirian V, Charbonneau S, Whitehead V, Collin I, et al. The montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53(4):695–9. Memory Clinic-NPZ. The consorium to establish a Registry of Alzheimer’s disease CERAD-plus. Basel, Switzerland: Basel Memory Clinic-NPZ; 2005. von Aster M, Neubauer A, Horn R, editors. Wechsler Intelligenztest für Erwachsene WIE. Deutsch-sprachige Bearbeitung und Adaptation des WAIS-III von David Wechsler (2., korrigierte Auflage). Frankfurt, Germany: Pearson Assessment; 2006. Sturm W, Willmes K, Horn W. Leistungsprüfsystem für 50-90-Jährige (LPS 50+). Göttingen, Germany: Hogrefe; 1993. Emre M, Aarsland D, Brown R, Burn DJ, Duyckaerts C, Mizuno Y, et al. Clinical diagnostic criteria for dementia associated with Parkinson’s disease. Mov Disord. 2007;22(12):1689–837. Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap): a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42(2):377–81. R Core Team. R: a language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing; 2020. Ruscio J. Constructing confidence intervals for spearman's rank correlation with ordinal data: a simulation study comparing analytic and bootstrap methods. J Mod App Stat Meth. 2008;7(2):416–34. Bonett DG, Wright TA. Sample size requirements for estimating Pearson, Kendall and Spearman correlations. Psychometrika. 2000;65(1):23–8. Chan YH. Biostatistics 104: correlational analysis. Singapore Med J. 2003;44(12):614–9. Evers A. The revised Dutch rating system for test quality. Int J Test. 2001;1(2):155–82. Fisseni HJ. Lehrbuch der psychologischen Diagnostik (2., überarbeitete und erweiterte Auflage). Göttingen, Germany: Hogrefe; 1997. Leiguarda RC, Pramstaller PP, Merello M, Starkstein S, Lees AJ, Marsden CD. Apraxia in Parkinson’s disease, progressive supranuclear palsy, multiple system atrophy and neuroleptic-induced parkinsonism. Brain. 1997;120(Pt 1):75–90. Ozsancak C, Auzou P, Dujardin K, Quinn N, Destée A. Orofacial apraxia in corticobasal degeneration, progressive supranuclear palsy, multiple system atrophy and Parkinson’s disease. J Neurol. 2004;251(11):1317–23. Foundas AL, Duncan ES. Limb apraxia: a disorder of learned skilled movement. Curr Neurol Neurosci Rep. 2019;19(10):82–13. Hagmann S, Goldenberg G. Therapy of activities of daily living in patients with apraxia. Neuropsychol Rehabil. 1998;8(2):123–41. Hanna-Pladdy B, Heilman KM, Foundas AL. Ecological implications of ideomotor apraxia: evidence from physical activities of daily living. Neurology. 2003 Feb 11;60(3):487–90. Smania N, Aglioti S, Girardi F, Tinazzi M, Fiaschi A, Cosentino A, et al. Rehabilitation of limb apraxia improves daily life activities in patients with stroke. Neurology. 2006;67(11):2050–2. Foki T, Vanbellingen T, Lungu C, Pirker W, Bohlhalter S, Nyffeler T, et al. Limb-kinetic apraxia affects activities of daily living in Parkinson’s disease: a multi-center study. Eur J Neurol. 2016;23(8):1301–7. Aarsland D, Andersen K, Larsen JP, Lolk A, Nielsen H, Kragh-Sørensen P. Risk of dementia in Parkinson’s disease: a community-based, prospective study. Neurology. 2001;56(6):730–6. Hely MA, Reid WGJ, Adena MA, Halliday GM, Morris JGL. The Sydney multicenter study of Parkinson’s disease: the inevitability of dementia at 20 years. Mov Disord. 2008;23(6):837–44. Schneider JS, Sendek S, Yang C. Relationship between motor symptoms, cognition, and demographic characteristics in treated mild/moderate Parkinson’s disease. PLoS One. 2015;10(4):e0123231. Article / Publication DetailsFirst-Page Preview
Received: March 21, 2022
Accepted: June 16, 2022
Published online: July 18, 2022
Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 3
ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)
For additional information: https://www.karger.com/DEM
Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
留言 (0)