Within-Visit Blood Pressure Variability and All-Cause and Stroke Mortality: Thai Epidemiologic Stroke (TES) Study

Hanchaiphiboolkul S. · Puthkhao P. · Tantirittisak T. · Na Songkhla K. · Komonchan S. · Worakijthamrongchai T. · Thiraworawong T.

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Article / Publication Details Abstract

Introduction: The association between within-visit blood pressure variability (BPV) and all-cause and stroke mortality remains uncertain. The aim of our study was to assess the association of within-visit BPV with all cause and stroke mortality. Methods: The study was conducted among participants from Thai Epidemiologic Stroke study which is a prospective community-based cohort study, recruited participants from the general population from five regions of Thailand. This study included 19,614 participants aged 45-80 years, who were free of stroke and had three blood pressure (BP) measurements, taken one minute apart, at baseline. Within-visit systolic blood pressure (SBP) and diastolic blood pressure (DBP) variability were expressed as the maximum absolute difference (MAD) between any two readings among the three repeated sequential measurements of SBP and DBP respectively. The participants were followed up for mortality. Cox regression analysis was used to identify the association of within-visit BPV with all cause and stroke mortality. Hazard ratio (HR) and 95% confidence intervals were used to illustrate the associations. Results: During a median follow-up of 11.1 years, 305 participants died of stroke, and 3,173 participants died of non-stroke cause. In unadjusted analyses, high within-visit MAD of SBP was significantly associated with all-cause (HR, 1.19; 95% CI, 1.09-1.31; p

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