Available online 14 July 2022, 102612

A leukoplakia of the tongue disappeared after oral treatment with C. butyricum.

The regulatory T cells in peripheral blood increased after administration of C. butyricum.

Clostridium butyricum could improve chronic graft versus host disease.

We report a case with leukoplakia of the tongue as a manifestation of chronic graft versus host disease after allogeneic stem cell transplantation for acute promyelocytic leukemia treated with Clostridium butyricum tablets. His leukoplakia subsequently disappeared and his regulatory T cells increased after three months.

Chronic graft-versus-host disease

Regulatory T cell

Leukoplakia

Clostridium butyricum

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