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Non-IgE-Dependent Hypersensitivity to Rocuronium Reversed by Sugammadex: Report of Three Cases and Hypothesis on the Underlying Mechanism.

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Mas-Related G Protein-Coupled Receptor-X2 (MRGPRX2) in Drug Hypersensitivity Reactions.

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Revisiting the role of MRGPRX2 on hypersensitivity reactions to neuromuscular blocking drugs.

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Heterogeneity of Human Mast Cells With Respect to MRGPRX2 Receptor Expression and Function.

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Upregulation of Mas-related G Protein coupled receptor X2 in asthmatic lung mast cells and its activation by the novel neuropeptide hemokinin-1.

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Human Mast Cell Proteome Reveals Unique Lineage, Putative Functions, and Structural Basis for Cell Ablation.

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Inflamed Ulcerative Colitis Regions Associated With MRGPRX2-Mediated Mast Cell Degranulation and Cell Activation Modules, Defining a New Therapeutic Target.

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The pseudoallergen receptor MRGPRX2 on peripheral blood basophils and eosinophils: Expression and function.

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Surface expression of MRGPRX2 on resting basophils: An area of controversy.

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MRGPRX2 Is the Codeine Receptor of Human Skin Mast Cells: Desensitization through β-Arrestin and Lack of Correlation with the FcεRI Pathway.

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A mast-cell-specific receptor mediates Iopamidol induced immediate IgE-independent anaphylactoid reactions.

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A group of cationic amphiphilic drugs activates MRGPRX2 and induces scratching behavior in mice.

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Quinolone antibiotics.

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Anaphylaxis to quinolones in mastocytosis: Hypothesis on the mechanism.

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Mast cell-mediated hypersensitivity to fluoroquinolone is MRGPRX2 dependent.

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Use of the relative release index for histamine in LAD2 cells to evaluate the potential anaphylactoid effects of drugs.

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MRGPRX2 and Immediate Drug Hypersensitivity: Insights from Cultured Human Mast Cells.

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Novel Insights on MRGPRX2-Mediated Hypersensitivity to Neuromuscular Blocking Agents And Fluoroquinolones.

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Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children: executive summary.

Clin Infect Dis. 52: 285-292Savoldi A. Azzini A.M. Baur D. et al.

Is there still a role for vancomycin in skin and soft-tissue infections?.

Curr Opin Infect Dis. 31: 120-130

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Front Immunol. 12: 676354

Vancomycin revisited - 60 years later.

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Vancomycin Infusion Reaction - Moving beyond “Red Man Syndrome”.

N Engl J Med. 384: 1283-1286

Red man syndrome.

Crit Care. 7: 119-120Azimi E. Reddy V.B. Lerner E.A.

Brief communication: MRGPRX2, atopic dermatitis and red man syndrome.

Itch (Phila). 2: e5Grimes J. Desai S. Charter N.W. et al.

MrgX2 is a promiscuous receptor for basic peptides causing mast cell pseudo-allergic and anaphylactoid reactions.

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Vancomycin immediate skin responses in vancomycin-naïve subjects.

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Mechanisms of nonimmunological histamine and tryptase release from human cutaneous mast cells.

Anesthesiology. 92: 1074-1081Fujisawa D. Kashiwakura J. Kita H. et al.

Expression of Mas-related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticaria.

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Vancomycin skin tests and prediction of “red man syndrome” in healthy volunteers.

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Anaphylaxis during anesthesia in France: an 8-year national survey.

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Life-threatening anaphylactoid reactions to muscle relaxants.

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Rocuronium Hypersensitivity: Does Off-Target Occupation of the MRGPRX2 Receptor Play a Role?.

J Allergy Clin Immunol Pract. 7: 998-1003Subramanian H. Gupta K. Ali H.

Roles of Mas-related G protein-coupled receptor X2 on mast cell-mediated host defense, pseudoallergic drug reactions, and chronic inflammatory diseases.

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Cisatracurium induces mast cell activation and pseudo-allergic reactions via MRGPRX2.

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Mivacurium induce mast cell activation and pseudo-allergic reactions via MAS-related G protein coupled receptor-X2.

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MRGPRX2 activation in mast cells by neuromuscular blocking agents and other agonists: Modulation by sugammadex.

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Skin reactions to intradermal neuromuscular blocking agent injections: a randomized multicenter trial in healthy volunteers.

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Weal and flare responses to intradermal rocuronium and cisatracurium in humans.

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MRGPRX2 Activation Causes Increased Skin Reactivity in Patients with Chronic Spontaneous Urticaria.

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Neuromuscular blocking agents induced anaphylaxis: Results and trends of a French pharmacovigilance survey from 2000 to 2012.

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Anaphylaxis is more common with rocuronium and succinylcholine than with atracurium.

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Anaphylaxis to neuromuscular blocking drugs: incidence and cross-reactivity in Western Australia from 2002 to 2011.

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Association between mutated Mas-related G protein-coupled receptor-X2 and rocuronium-induced intraoperative anaphylaxis.

Br J Anaesth. 125: e446-e448Lansu K. Karpiak J. Liu J. et al.

In silico design of novel probes for the atypical opioid receptor MRGPRX2.

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MRGPRX2 Activation by Rocuronium: Insights from Studies with Human Skin Mast Cells and Missense Variants.

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Mechanisms of human drug-induced anaphylaxis.

J Allergy Clin Immunol. 147: 1133-1142

Allergic reactions to drugs: implications for perioperative care.

J Perianesth Nurs. 17: 393-398Casale T.B. Bowman S. Kaliner M.

Induction of human cutaneous mast cell degranulation by opiates and endogenous opioid peptides: evidence for opiate and nonopiate receptor participation.

J Allergy Clin Immunol. 73: 775-781Sheen C.H. Schleimer R.P. Kulka M.

Codeine induces human mast cell chemokine and cytokine production: involvement of G-protein activation.

Allergy. 62: 532-538Harle D.G. Baldo B.A. Coroneos N.J. et al.

Anaphylaxis following administration of papaveretum. Case report: Implication of IgE antibodies that react with morphine and codeine, and identification of an allergenic determinant.

Anesthesiology. 71: 489-494

Emerging Roles for MAS-Related G Protein-Coupled Receptor-X2 in Host Defense Peptide, Opioid, and Neuropeptide-Mediated Inflammatory Reactions.

Adv Immunol. 136: 123-162

Neuraxial opioid-induced pruritus: An update.

J Anaesthesiol Clin Pharmacol. 29: 303-307

Histamine-releasing and allergenic properties of opioid analgesic drugs: resolving the two.

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Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia.

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Purification and characterization of human skin mast cells. Evidence for human mast cell heterogeneity.

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Functional heterogeneity of human mast cells from different anatomic sites: in vitro responses to morphine sulfate.

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Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids.

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Relationship between MRGPRX2 and pethidine hydrochloride- or fentanyl citrate-induced LAD2 cell degranulation.

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Opioid-induced pruritus: an update.

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Side Effect Rates of Opioids in Equianalgesic Doses via Intravenous Patient-Controlled Analgesia: A Systematic Review and Network Meta-analysis.

Anesth Analg. 129: 1153-1162

Anaphylaxis to radiographic contrast media.

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Surveillance of contrast-media-induced hypersensitivity reactions using signals from an electronic medical recording system.

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Varied incidence of immediate adverse reactions to low-osmolar non-ionic iodide radiocontrast media used in computed tomography.

Clin Exp Allergy. 47: 106-112

X-ray contrast media--an overview.

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Immediate reactions to iodinated contrast media.

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Immediate and delayed reactions to radiocontrast media: is there an allergic mechanism?.

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Anaphylaxis to iodinated contrast material: nonallergic hypersensitivity or IgE-mediated allergy?.

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Immediate reactions following iodinated contrast media injection: a study of 38 cases.

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Anaphylaxis to iodinated contrast media: clinical characteristics related with development of anaphylactic shock.

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HLA-DRB1∗15: 02 Is Associated With Iodinated Contrast Media-Related Anaphylaxis.

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Randomized placebo-controlled trial of the bradykinin B₂ receptor antagonist icatibant for the treatment of acute attacks of hereditary angioedema: the FAST-3 trial.

Ann Allergy Asthma Immunol. 107: 529-537Bas M. Greve J. Stelter K. et al.

A randomized trial of icatibant in ACE-inhibitor-induced angioedema.

N Engl J Med. 372: 418-425Sinert R. Levy P. Bernstein J.A. et al.

Randomized Trial of Icatibant for Angiotensin-Converting Enzyme Inhibitor-Induced Upper Airway Angioedema.

J Allergy Clin Immunol Pract. 5: 1402-1409 e1403Liu R. Che D. Zhao T. et al.

MRGPRX2 is essential for sinomenine hydrochloride induced anaphylactoid reactions.

Biochem Pharmacol. 146: 214-223Huang L. Dong Y. Wu J. et al.

Sinomenine-induced histamine release-like anaphylactoid reactions are blocked by tranilast via inhibiting NF-κB signaling.

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The dual regulation of substance P-mediated inflammation via human synovial mast cells in rheumatoid arthritis.

Allergol Int. 66S: S9-S20Rouzaire P. Nosbaum A. Mullet C. et al.

Immediate allergic hypersensitivity to quinolones associates with neuromuscular blocking agent sensitization.

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On the origin and specificity of antibodies to neuromuscular blocking (muscle relaxant) drugs: an immunochemical perspective.

Clin Exp Allergy. 39: 325-344Babina M. Wang Z. Franke K. et al.

Thymic Stromal Lymphopoietin Promotes MRGPRX2-Triggered Degranulation of Skin Mast Cells in a STAT5-Dependent Manner with Further Support from JNK.

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Mastocytosis and Anaphylaxis.

Immunol Allergy Clin North Am. 37: 153-164Deepak V. Komarow H.D. Alblaihess A.A. et al.

Expression of MRGPRX2 in skin mast cells of patients with maculopapular cutaneous mastocytosis.

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Management around invasive procedures in mastocytosis: An update.

Ann Allergy Asthma Immunol. 119: 304-309Doña I. Blanca-López N. Boteanu C. et al.

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J Investig Allergol Clin Immunol. 31: 292-307Roy S. Chompunud Na Ayudhya C. Thapaliya M. et al.

Multifaceted MRGPRX2: New insight into the role of mast cells in health and disease.

J Allergy Clin Immunol. 148: 293-308Alkanfari I. Gupta K. Jahan T. et al.

Naturally Occurring Missense MRGPRX2 Variants Display Loss of Function Phenotype for Mast Cell Degranulation in Response to Substance P, Hemokinin-1, Human beta-Defensin-3, and Icatibant.

J Immunol. 201: 343-349Chompunud Na Ayudhya C. Roy S. Alkanfari I. et al.

Identification of Gain and Loss of Function Missense Variants in MRGPRX2's Transmembrane and Intracellular Domains for Mast Cell Activation by Substance P.

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Minireview: Mas-related G protein-coupled receptor X2 activation by therapeutic drugs.

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IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper.

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Practical Guidance for the Evaluation and Management of Drug Hypersensitivity: General Concepts.

J Allergy Clin Immunol Pract. 8: S3-S15Mayorga C. Celik G. Rouzaire P. et al.

In vitro tests for drug hypersensitivity reactions: an ENDA/EAACI Drug Allergy Interest Group position paper.

Allergy. 71: 1103-1134Elst J. Sabato V. Hagendorens M.M. et al.

Measurement and Functional Analysis of the Mas-Related G Protein-Coupled Receptor MRGPRX2 on Human Mast Cells and Basophils.

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Basophil Activation Experiments in Immediate Drug Hypersensitivity: More Than a Diagnostic Aid.

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Immunoglobulin E cross-linking or MRGPRX2 activation: clinical insights from rocuronium hypersensitivity.

Br J Anaesth. 126: e27-e29Elst J. van der Poorten M.M. Van Gasse A.L. et al.

Mast cell activation tests by flow cytometry: A new diagnostic asset?.

Clin Exp Allergy. 51: 1482-1500

Drug allergy: an updated practice parameter.

Ann Allergy Asthma Immunol. 105: 259-273Azimi E. Reddy V.B. Shade K.C. et al.

Dual action of neurokinin-1 antagonists on Mas-related GPCRs.

JCI Insight. 1: e89362Mencarelli A. Gunawan M. Yong K.S.M. et al.

A humanized mouse model to study mast cells mediated cutaneous adverse drug reactions.

J Leukoc Biol. 107: 797-807Ogasawara H. Furuno M. Edamura K. et al.

Novel MRGPRX2 antagonists inhibit IgE-independent activation of human umbilical cord blood-derived mast cells.

J Leukoc Biol. 106: 1069-1077Suzuki Y. Liu S. Ogasawara T. et al.

A novel MRGPRX2-targeting antagonistic DNA aptamer inhibits histamine release and prevents mast cell-mediated anaphylaxis.

Eur J Pharmacol. 878: 173104Callahan B.N. Kammala A.K. Syed M. et al.

Osthole, a Natural Plant Derivative Inhibits MRGPRX2 Induced Mast Cell Responses.

Front Immunol. 11: 703Kumar M. Singh K. Duraisamy K. et al.

Protective Effect of Genistein against Compound 48/80 Induced Anaphylactoid Shock via Inhibiting MAS Related G Protein-Coupled Receptor X2 (MRGPRX2).

Molecules. 25Ding Y. Che D. Li C. et al.

Quercetin inhibits Mrgprx2-induced pseudo-allergic reaction via PLCγ-IP3R related Ca(2+) fluctuations.

Int Immunopharmacol. 66: 185-197Wang J. Zhang Y. Li C. et al.

Inhibitory function of Shikonin on MRGPRX2-mediated pseudo-allergic reactions induced by the secretagogue.

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