Everolimus Concentration in Saliva to Predict Stomatitis: A Feasibility Study in Patients with Cancer

*Department of Pharmacy and Pharmacology, the Netherlands Cancer Institute—Antoni van Leeuwenhoek;

†Department of Hospital Pharmacy, Amsterdam University Medical Center, Amsterdam;

‡Department of Pharmaceutical Sciences, Utrecht University, Utrecht;

§Department of Medical Oncology and Clinical Pharmacology, the Netherlands Cancer Institute—Antoni van Leeuwenhoek, Amsterdam;

¶Department of Clinical Pharmacy, University Medical Center Utrecht, Utrecht University, Utrecht; and

‖Department of Pharmacology, Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.

Correspondence: Laura Molenaar-Kuijsten, PharmD, MSc, Department of Pharmacy and Pharmacology, the Netherlands Cancer Institute—Antoni van Leeuwenhoek, the Netherlands (e-mail: [email protected]).

Greiner Bio-One Saliva Collection System kits were supplied by Greiner Bio-One B. V. Greiner Bio-One B. V. had no involvement in the study design, sample collection, data analysis, writing of the article, and the decision to submit the article for publication.

J. H. Beijnen (partly) holds a patent on oral taxane formulations and is a part-time employee and stockholder of Modra Pharmaceuticals, a spin-out company developing oral taxanes. This is not related to the manuscript. N. Steeghs provided consultation or attended advisory boards for AIMM Therapeutics, Boehringer Ingelheim, and Ellipses Pharma and received research grants for the institute from AB Science, Abbvie, Actuate Therapeutics, Amgen, Array, AstraZeneca/MedImmune, Bayer, Blueprint Medicines, Boehringer Ingelheim, Bristol-Myers Squibb, Cantargia, Cytovation, Deciphera, Genentech/Roche, GlaxoSmithKline, Incyte, InteRNA, Lilly, Merck Sharp & Dohme, Merus, Novartis, Pfizer, Pierre Fabre, Roche, Sanofi, Taiho, and Takeda (outside the submitted work). R. B. Verheijen reports share ownership and employment at Johnson & Johnson, prior share ownership and employment at AstraZeneca, and share ownership of Galapagos and Chinook Tx (outside of the submitted work). The other authors declare no conflict of interest.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.drug-monitoring.com).

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