Baio J, Wiggins L, Christensen D, Maenner M, Daniels J, Warren Z, et al. Prevalence of autism spectrum disorder among children aged 8 years- autism and developmental disabilities monitoring network, 11 sites, United States, 2014. MMWR Surveill Summ. 2018;67(6):1–23.

PubMed  PubMed Central  Article  Google Scholar 

Landrigan PJ, Lambertini L, Birnbaum LS. A research strategy to discover the environmental causes of autism and neurodevelopmental disabilities. Environ Health Perspect. 2012;120(7):a258-60.

PubMed  PubMed Central  Article  Google Scholar 

Toth M. Mechanisms of non-genetic inheritance and psychiatric disorders. Neuropsychopharmacology. 2015;40(1):129–40.

PubMed  Article  Google Scholar 

Rodgers AB, Morgan CP, Leu NA, Bale TL. Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress. Proc Natl Acad Sci USA. 2015;112(44):13699–704.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Haugen AC, Schug TT, Collman G, Heindel JJ. Evolution of DOHaD: the impact of environmental health sciences. J Dev Orig Health Dis. 2015;6(2):55–64.

CAS  PubMed  Article  Google Scholar 

Meyer U. Neurodevelopmental resilience and susceptibility to maternal immune activation. Trends Neurosci. 2019;42(11):793–806.

CAS  PubMed  Article  Google Scholar 

Zhou Y, Zhang M, Liu W, Li Y, Qin Y, Xu Y. Transgenerational transmission of neurodevelopmental disorders induced by maternal exposure to PM2.5. Chemosphere. 2020;255:126920.

CAS  PubMed  Article  Google Scholar 

Kioumourtzoglou MA, Coull BA, O’Reilly ÉJ, Ascherio A, Weisskopf MG. Association of exposure to diethylstilbestrol during pregnancy with multigenerational neurodevelopmental deficits. JAMA Pediatr. 2018;172(7):670–7.

PubMed  PubMed Central  Article  Google Scholar 

Quinnies KM, Doyle TJ, Kim KH, Rissman EF. Transgenerational effects of di-(2-ethylhexyl) phthalate (DEHP) on stress hormones and behavior. Endocrinology. 2015;156(9):3077–83.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Weber-Stadlbauer U, Richetto J, Zwamborn RAJ, Slieker RC, Meyer U. Transgenerational modification of dopaminergic dysfunctions induced by maternal immune activation. Neuropsychopharmacology. 2021;46(2):404–12.

CAS  PubMed  Article  Google Scholar 

Angelidou A, Asadi S, Alysandratos KD, Karagkouni A, Kourembanas S, Theoharides TC. Perinatal stress, brain inflammation and risk of autism-review and proposal. BMC Pediatr. 2012;12:89.

PubMed  PubMed Central  Article  Google Scholar 

Class QA, Abel KM, Khashan AS, Rickert ME, Dalman C, Larsson H, et al. Offspring psychopathology following preconception, prenatal and postnatal maternal bereavement stress. Psychol Med. 2014;44(1):71–84.

CAS  PubMed  Article  Google Scholar 

Manners MT, Yohn NL, Lahens NF, Grant GR, Bartolomei MS, Blendy JA. Transgenerational inheritance of chronic adolescent stress: effects of stress response and the amygdala transcriptome. Genes Brain Behav. 2019;18(7):e12493.

CAS  PubMed  Article  Google Scholar 

Qiu A, Anh TT, Li Y, Chen H, Rifkin-Graboi A, Broekman BF, et al. Prenatal maternal depression alters amygdala functional connectivity in 6-month-old infants. Transl Psychiatry. 2015;5(2):e508.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Kemp JVA, Bernier E, Lebel C, Kopala-Sibley DC. Associations between parental mood and anxiety psychopathology and offspring brain structure: a scoping review. Clin Child Fam Psychol Rev. 2022;25(1):222–47.

PubMed  Article  Google Scholar 

Avino TA, Barger N, Vargas MV, Carlson EL, Amaral DG, Bauman MD, et al. Neuron numbers increase in the human amygdala from birth to adulthood, but not in autism. Proc Natl Acad Sci USA. 2018;115(14):3710–5.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Shen MD, Li DD, Keown CL, Lee A, Johnson RT, Angkustsiri K, et al. Functional connectivity of the amygdala is disrupted in preschool-aged children with autism spectrum disorder. J Am Acad Child Adolesc Psychiatry. 2016;55(9):817–24.

PubMed  PubMed Central  Article  Google Scholar 

Rojas DC, Smith JA, Benkers TL, Camou SL, Reite ML, Rogers SJ. Hippocampus and amygdala volumes in parents of children with autistic disorder. Am J Psychiatry. 2004;161(11):2038–44.

PubMed  Article  Google Scholar 

Schumann CM, Amaral DG. Stereological analysis of amygdala neuron number in autism. J Neurosci. 2006;26(29):7674–9.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Lin HC, Gean PW, Wang CC, Chan YH, Chen PS. The amygdala excitatory/inhibitory balance in a valproate-induced rat autism model. PLoS ONE. 2013;8(1):e55248.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Markram K, Rinaldi T, La Mendola D, Sandi C, Markram H. Abnormal fear conditioning and amygdala processing in an animal model of autism. Neuropsychopharmacology. 2008;33(4):901–12.

PubMed  Article  Google Scholar 

Rubenstein JL, Merzenich MM. Model of autism: increased ratio of excitation/inhibition in key neural systems. Genes Brain Behav. 2003;2:255–67.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Phillips M, Pozzo-Miller L. Dendritic spine dysgenesis in autism related disorders. Neurosci Lett. 2015;601:30–40.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Hutsler JJ, Zhang H. Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders. Brain Res. 2010;1309:83–94.

CAS  PubMed  Article  Google Scholar 

Fatemi SH, Reutiman TJ, Folsom TD, Rustan OG, Rooney RJ, Thuras PD. Downregulation of GABAA receptor protein subunits alpha6, beta2, delta, epsilon, gamma2, theta, and rho2 in superior frontal cortex of subjects with autism. J Autism Dev Disord. 2014;44(8):1833–45.

PubMed  Article  Google Scholar 

Purcell AE, Jeon OH, Zimmerman AW, Blue ME, Pevsner J. Postmortem brain abnormalities of the glutamate neurotransmitter system in autism. Neurology. 2001;57(9):1618–28.

CAS  PubMed  Article  Google Scholar 

Fatemi SH, Reutiman TJ, Folsom TD, Thuras PD. GABA(A) receptor downregulation in brains of subjects with autism. J Autism Dev Disord. 2009;39(2):223–30.

PubMed  Article  Google Scholar 

Oblak AL, Gibbs TT, Blatt GJ. Reduced GABAA receptors and benzodiazepine binding sites in the posterior cingulate cortex and fusiform gyrus in autism. Brain Res. 2011;1380:218–28.

CAS  PubMed  Article  Google Scholar 

Guang S, Pang N, Deng X, Yang L, He F, Wu L, et al. Synaptopathology involved in autism spectrum disorder. Front Cell Neurosci. 2018;12:470.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Weber-Stadlbauer U, Richetto J, Labouesse MA, Bohacek J, Mansuy IM, Meyer U. Transgenerational transmission and modification of pathological traits induced by prenatal immune activation. Mol Psychiatry. 2017;22(1):102–12.

CAS  PubMed  Article  Google Scholar 

Choi CS, Gonzales EL, Kim KC, Yang SM, Kim JW, Mabunga DF, et al. The transgenerational inheritance of autism-like phenotypes in mice exposed to valproic acid during pregnancy. Sci Rep. 2016;6:36250.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Ramamoorthi K, Lin Y. The contribution of GABAergic dysfunction to neurodevelopmental disorders. Trends Mol Med. 2011;17(8):452–62.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Hogart A, Wu D, LaSalle JM, Schanen NC. The comorbidity of autism with the genomic disorders of chromosome 15q11.2-q13. Neurobiol Dis. 2010;38(2):181–91.

CAS  PubMed  Article  Google Scholar 

Samaco R, Hogart A, LaSalle J. Epigenetic overlap in autism-spectrum neurodevelopmental disorders: MECP2 deficiency causes reduced expression of UBE3A and GABRB3. Hum Mol Genet. 2005;14(4):483–92.

CAS  PubMed  Article  Google Scholar 

Delahanty RJ, Kang JQ, Brune CW, Kistner EO, Courchesne E, Cox NJ, et al. Maternal transmission of a rare GABRB3 signal peptide variant is associated with autism. Mol Psychiatry. 2011;16(1):86–96.

CAS  PubMed  Article  Google Scholar 

Nakatani J, Tamada K, Hatanaka F, Ise S, Ohta H, Inoue K, et al. Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism. Cell. 2009;137(7):1235–46.

PubMed  PubMed Central  Article  Google Scholar 

Vien TN, Modgil A, Abramian AM, Jurd R, Walker J, Brandon NJ, et al. Compromising the phosphodependent regulation of the GABAAR beta3 subunit reproduces the core phenotypes of autism spectrum disorders. Proc Natl Acad Sci USA. 2015;112(48):14805–10.

CAS  PubMed  PubMed Central  Article