Mucosal viral infection induces a regulatory T cell activation phenotype distinct from tissue residency in mouse and human tissues

Fontenot, J. D., Gavin, M. A. & Rudensky, A. Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 4, 330–336 (2003).

CAS  PubMed  Article  Google Scholar 

Hori, S., Nomura, T. & Sakaguchi, S. Control of regulatory T cell development by the transcription factor Foxp3. Science 299, 1057–1061 (2003).

CAS  PubMed  Article  Google Scholar 

Josefowicz, S. Z. & Rudensky, A. Control of regulatory T cell lineage commitment and maintenance. Immunity 30, 616–625 (2009).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Khattri, R., Cox, T., Yasayko, S. A. & Ramsdell, F. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat. Immunol. 4, 337–342 (2003).

CAS  PubMed  Article  Google Scholar 

Williams, L. M. & Rudensky, A. Y. Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nat. Immunol. 8, 277–284 (2007).

CAS  PubMed  Article  Google Scholar 

Kuswanto, W. et al. Poor repair of skeletal muscle in aging mice reflects a defect in local, interleukin-33-dependent accumulation of regulatory T cells. Immunity 44, 355–367 (2016).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Burzyn, D. et al. A special population of regulatory T cells potentiates muscle repair. Cell 155, 1282–1295 (2013).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Feuerer, M. et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat. Med. 15, 930–939 (2009).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Cipolletta, D. et al. PPAR-gamma is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature 486, 549–553 (2012).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Li, C. et al. TCR transgenic mice reveal stepwise, multi-site acquisition of the distinctive Fat-Treg Phenotype. Cell 174, 285–299 e212 (2018).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Kalekar, L. A. et al. Regulatory T cells in skin are uniquely poised to suppress profibrotic immune responses. Sci. Immunol. 4, eaaw2910 (2019).

Ali, N. et al. Regulatory T cells in skin facilitate epithelial stem cell differentiation. Cell 169, 1119–1129 e1111 (2017).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Mathur, A. N. et al. Treg-cell control of a CXCL5-IL-17 inflammatory axis promotes hair-follicle-stem-cell differentiation during skin-barrier repair. Immunity 50, 655–667 e654 (2019).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Sanchez Rodriguez, R. et al. Memory regulatory T cells reside in human skin. J. Clin. Invest. 124, 1027–1036 (2014).

PubMed  PubMed Central  Article  CAS  Google Scholar 

Shafiani, S., Tucker-Heard, G., Kariyone, A., Takatsu, K. & Urdahl, K. B. Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosis. J. Exp. Med. 207, 1409–1420 (2010).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Kolodin, D. et al. Antigen- and cytokine-driven accumulation of regulatory T cells in visceral adipose tissue of lean mice. Cell Metab. 21, 543–557 (2015).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Tanoue, T., Atarashi, K. & Honda, K. Development and maintenance of intestinal regulatory T cells. Nat. Rev. Immunol. 16, 295–309 (2016).

CAS  PubMed  Article  Google Scholar 

Cosovanu, C. & Neumann, C. The many functions of Foxp3(+) regulatory T cells in the intestine. Front Immunol. 11, 600973 (2020).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Noval Rivas, M. & Chatila, T. A. Regulatory T cells in allergic diseases. J. Allergy Clin. Immunol. 138, 639–652 (2016).

CAS  PubMed  Article  Google Scholar 

Singh, R. et al. Regulatory T cells in respiratory health and diseases. Pulm. Med. 2019, 1907807 (2019).

PubMed  PubMed Central  Article  CAS  Google Scholar 

Chatila, T. A. et al. JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome. J. Clin. Invest. 106, R75–R81 (2000).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Verbsky, J. W. & Chatila, T. A. Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) and IPEX-related disorders: an evolving web of heritable autoimmune diseases. Curr. Opin. Pediatr. 25, 708–714 (2013).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Kearley, J., Barker, J. E., Robinson, D. S. & Lloyd, C. M. Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent. J. Exp. Med. 202, 1539–1547 (2005).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Lewkowich, I. P. et al. CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function. J. Exp. Med. 202, 1549–1561 (2005).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Josefowicz, S. Z. et al. Extrathymically generated regulatory T cells control mucosal TH2 inflammation. Nature 482, 395–399 (2012).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Hartl, D. et al. Quantitative and functional impairment of pulmonary CD4+CD25hi regulatory T cells in pediatric asthma. J. Allergy Clin. Immunol. 119, 1258–1266 (2007).

CAS  PubMed  Article  Google Scholar 

Arpaia, N. et al. A distinct function of regulatory T cells in tissue protection. Cell 162, 1078–1089 (2015).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Belkaid, Y., Piccirillo, C. A., Mendez, S., Shevach, E. M. & Sacks, D. L. CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature 420, 502–507 (2002).

CAS  PubMed  Article  Google Scholar 

Loebbermann, J. et al. Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection. Mucosal Immunol. 5, 161–172 (2012).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Mendez, S., Reckling, S. K., Piccirillo, C. A., Sacks, D. & Belkaid, Y. Role for CD4(+) CD25(+) regulatory T cells in reactivation of persistent leishmaniasis and control of concomitant immunity. J. Exp. Med. 200, 201–210 (2004).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Shafiani, S. et al. Pathogen-specific Treg cells expand early during mycobacterium tuberculosis infection but are later eliminated in response to Interleukin-12. Immunity 38, 1261–1270 (2013).

CAS  PubMed  Article  Google Scholar 

Suvas, S., Azkur, A. K., Kim, B. S., Kumaraguru, U. & Rouse, B. T. CD4+CD25+ regulatory T cells control the severity of viral immunoinflammatory lesions. J. Immunol. 172, 4123–4132 (2004).

CAS  PubMed  Article  Google Scholar 

Gebhardt, T. et al. Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus. Nat. Immunol. 10, 524–530 (2009).

CAS  PubMed  Article  Google Scholar 

Turner, D. L. & Farber, D. L. Mucosal resident memory CD4 T cells in protection and immunopathology. Front Immunol. 5, 331 (2014).

PubMed  PubMed Central  Article  CAS  Google Scholar 

Woodward Davis, A. S. et al. The human memory T cell compartment changes across tissues of the female reproductive tract. Mucosal Immunol. 14, 862–872 (2021).

CAS  PubMed  Article  Google Scholar 

Dave, V. A. et al. Cervicovaginal Tissue Residence Confers a Distinct Differentiation Program upon Memory CD8 T Cells. J. Immunol. 206, 2937–2948 (2021).

Iijima, N. & Iwasaki, A. T cell memory. A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells. Science 346, 93–98 (2014).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Roychoudhury, P. et al. Tissue-resident T cell-derived cytokines eliminate herpes simplex virus-2-infected cells. J. Clin. Invest. 130, 2903–2919 (2020).

CAS  PubMed  PubMed Central 

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