Two lymphoid cell lines potently silence unintegrated HIV-1 DNAs

Coffin JM, Hughes SH, Varmus HE Eds.: The interactions of retroviruses and their hosts. In: Retroviruses. New York: Cold Spring Harbor; 1997.

Swanstrom R, Wills JW Eds.: Synthesis, assembly, and processing of viral proteins. In: Retroviruses. New York: Cold Spring Harbor; 1997.

Gianni AM, Smotkin D, Weinberg RA. Murine leukemia virus: detection of unintegrated double-stranded DNA forms of the provirus. Proc Natl Acad Sci U S A. 1975;72(2):447–51.

CAS  Article  Google Scholar 

Yoshimura FK, Weinberg RA. Restriction endonuclease cleavage of linear and closed circular murine leukemia viral DNAs: discovery of a smaller circular form. Cell. 1979;16(2):323–32.

CAS  Article  Google Scholar 

Hazuda DJ, Felock P, Witmer M, Wolfe A, Stillmock K, Grobler JA, Espeseth A, Gabryelski L, Schleif W, Blau C, et al. Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells. Science. 2000;287(5453):646–50.

CAS  Article  Google Scholar 

Wu Y, Marsh JW. Early transcription from nonintegrated DNA in human immunodeficiency virus infection. J Virol. 2003;77(19):10376–82.

CAS  Article  Google Scholar 

Kelly J, Beddall MH, Yu D, Iyer SR, Marsh JW, Wu Y. Human macrophages support persistent transcription from unintegrated HIV-1 DNA. Virology. 2008;372(2):300–12.

CAS  Article  Google Scholar 

Iyer SR, Yu D, Biancotto A, Margolis LB, Wu Y. Measurement of human immunodeficiency virus type 1 preintegration transcription by using Rev-dependent Rev-CEM cells reveals a sizable transcribing DNA population comparable to that from proviral templates. J Virol. 2009;83(17):8662–73.

CAS  Article  Google Scholar 

Wang GZ, Wang Y, Goff SP. Histones Are Rapidly Loaded onto Unintegrated Retroviral DNAs Soon after Nuclear Entry. Cell Host Microbe. 2016;20(6):798–809.

CAS  Article  Google Scholar 

Zhu Y, Wang GZ, Cingoz O, Goff SP. NP220 mediates silencing of unintegrated retroviral DNA. Nature. 2018;564(7735):278–82.

CAS  Article  Google Scholar 

Geis FK, Goff SP. Unintegrated HIV-1 DNAs are loaded with core and linker histones and transcriptionally silenced. Proc Natl Acad Sci U S A. 2019;116(47):23735–42.

CAS  Article  Google Scholar 

Machida S, Depierre D, Chen HC, Thenin-Houssier S, Petitjean G, Doyen CM, Takaku M, Cuvier O, Benkirane M. Exploring histone loading on HIV DNA reveals a dynamic nucleosome positioning between unintegrated and integrated viral genome. Proc Natl Acad Sci U S A. 2020;117(12):6822–30.

CAS  Article  Google Scholar 

Dupont L, Bloor S, Williamson JC, Cuesta SM, Shah R, Teixeira-Silva A, Naamati A, Greenwood EJD, Sarafianos SG, Matheson NJ, et al. The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr. Cell Host Microbe. 2021. https://doi.org/10.1016/j.chom.2021.03.001.

Article  PubMed  PubMed Central  Google Scholar 

Meltzer B, Dabbagh D, Guo J, Kashanchi F, Tyagi M, Wu Y. Tat controls transcriptional persistence of unintegrated HIV genome in primary human macrophages. Virology. 2018;518:241–52.

CAS  Article  Google Scholar 

Geis FK, Sabo Y, Chen X, Li Y, Lu C, Goff SP. CHAF1A/B mediate silencing of unintegrated HIV-1 DNAs early in infection. Proc Natl Acad Sci U S A. 2022. https://doi.org/10.1073/pnas.2116735119.

Article  PubMed  Google Scholar 

Poon AP, Gu H, Roizman B. ICP0 and the US3 protein kinase of herpes simplex virus 1 independently block histone deacetylation to enable gene expression. Proc Natl Acad Sci U S A. 2006;103(26):9993–8.

CAS  Article  Google Scholar 

Lucifora J, Baumert TF. Silencing of the HBV episome through degradation of HBx protein: Towards functional cure? J Hepatol. 2021;74(3):497–9.

Article  Google Scholar 

Irwan ID, Karnowski HL, Bogerd HP, Tsai K, Cullen BR. Reversal of Epigenetic Silencing Allows Robust HIV-1 Replication in the Absence of Integrase Function. MBio. 2020. https://doi.org/10.1128/mBio.01038-20.

Article  PubMed  PubMed Central  Google Scholar 

Irwan ID, Cullen BR. Tax Induces the Recruitment of NF-kappaB to Unintegrated HIV-1 DNA To Rescue Viral Gene Expression and Replication. J Virol. 2021;95(13): e0028521.

Article  Google Scholar 

Poon B, Chen IS. Human immunodeficiency virus type 1 (HIV-1) Vpr enhances expression from unintegrated HIV-1 DNA. J Virol. 2003;77(7):3962–72.

CAS  Article  Google Scholar 

Poon B, Chang MA, Chen IS. Vpr is required for efficient Nef expression from unintegrated human immunodeficiency virus type 1 DNA. J Virol. 2007;81(19):10515–23.

CAS  Article  Google Scholar 

Trinite B, Ohlson EC, Voznesensky I, Rana SP, Chan CN, Mahajan S, Alster J, Burke SA, Wodarz D, Levy DN. An HIV-1 replication pathway utilizing reverse transcription products that fail to integrate. J Virol. 2013;87(23):12701–20.

CAS  Article  Google Scholar 

Schneider WM, Wu DT, Amin V, Aiyer S, Roth MJ. MuLV IN mutants responsive to HDAC inhibitors enhance transcription from unintegrated retroviral DNA. Virology. 2012;426(2):188–96.

CAS  Article  Google Scholar 

Pelascini LP, Maggio I, Liu J, Holkers M, Cathomen T, Goncalves MA. Histone deacetylase inhibition rescues gene knockout levels achieved with integrase-defective lentiviral vectors encoding zinc-finger nucleases. Hum Gene Ther Methods. 2013;24(6):399–411.

CAS  Article  Google Scholar 

Schwartzberg P, Colicelli J, Goff SP. Construction and analysis of deletion mutations in the pol gene of Moloney murine leukemia virus: a new viral function required for productive infection. Cell. 1984;37(3):1043–52.

CAS  Article  Google Scholar 

Sakai H, Kawamura M, Sakuragi J, Sakuragi S, Shibata R, Ishimoto A, Ono N, Ueda S, Adachi A. Integration is essential for efficient gene expression of human immunodeficiency virus type 1. J Virol. 1993;67(3):1169–74.

CAS  Article  Google Scholar 

Wu Y, Marsh JW. Selective transcription and modulation of resting T cell activity by preintegrated HIV DNA. Science. 2001;293(5534):1503–6.

CAS  Article  Google Scholar 

Sloan RD, Donahue DA, Kuhl BD, Bar-Magen T, Wainberg MA. Expression of Nef from unintegrated HIV-1 DNA downregulates cell surface CXCR4 and CCR5 on T-lymphocytes. Retrovirology. 2010;7:44.

Article  Google Scholar 

Sloan RD, Kuhl BD, Donahue DA, Roland A, Bar-Magen T, Wainberg MA. Transcription of preintegrated HIV-1 cDNA modulates cell surface expression of major histocompatibility complex class I via Nef. J Virol. 2011;85(6):2828–36.

CAS  Article  Google Scholar 

Tsai K, Cullen BR. Epigenetic and epitranscriptomic regulation of viral replication. Nat Rev Microbiol. 2020;18(10):559–70.

CAS  Article  Google Scholar 

留言 (0)

沒有登入
gif