van der Poll T, et al. The immunopathology of sepsis and potential therapeutic targets. Nat Rev Immunol. 2017;17:407–20. https://doi.org/10.1038/nri.2017.36.
CAS Article PubMed Google Scholar
Fowler AA 3rd, et al. Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: the CITRIS-ALI randomized clinical trial. JAMA. 2019;322:1261–70. https://doi.org/10.1001/jama.2019.11825.
Article PubMed PubMed Central Google Scholar
Bellani G, et al. Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA. 2016;315:788–800. https://doi.org/10.1001/jama.2016.0291.
CAS Article PubMed Google Scholar
Cao X. COVID-19: immunopathology and its implications for therapy. Nat Rev Immunol. 2020;20:269–70. https://doi.org/10.1038/s41577-020-0308-3.
CAS Article PubMed PubMed Central Google Scholar
Huang C, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet. 2020;395:497–506. https://doi.org/10.1016/s0140-6736(20)30183-5.
Arulkumaran N, et al. Mitochondrial function in sepsis. Shock. 2016;45:271–81. https://doi.org/10.1097/shk.0000000000000463.
CAS Article PubMed PubMed Central Google Scholar
Yu J, et al. Heme oxygenase-1/carbon monoxide-regulated mitochondrial dynamic equilibrium contributes to the attenuation of endotoxin-induced acute lung injury in rats and in lipopolysaccharide-activated macrophages. Anesthesiology. 2016;125:1190–201. https://doi.org/10.1097/aln.0000000000001333.
CAS Article PubMed Google Scholar
Fredriksson K, et al. Mitochondrial function in sepsis: respiratory versus leg muscle. Crit Care Med. 2007;35:S449-453. https://doi.org/10.1097/01.Ccm.0000278048.00896.4b.
D’Amico D, et al. Cytosolic proteostasis networks of the mitochondrial stress response. Trends Biochem Sci. 2017;42:712–25. https://doi.org/10.1016/j.tibs.2017.05.002.
CAS Article PubMed Google Scholar
Mottis A, et al. Mitocellular communication: Shaping health and disease. Science (New York, NY). 2019;366:827–32. https://doi.org/10.1126/science.aax3768.
Quirós PM, et al. Mitonuclear communication in homeostasis and stress. Nat Rev Mol Cell Biol. 2016;17:213–26. https://doi.org/10.1038/nrm.2016.23.
CAS Article PubMed Google Scholar
Pellegrino MW, et al. Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection. Nature. 2014;516:414–7. https://doi.org/10.1038/nature13818.
CAS Article PubMed PubMed Central Google Scholar
Xu M, et al. Choline ameliorates cardiac hypertrophy by regulating metabolic remodelling and UPRmt through SIRT3-AMPK pathway. Cardiovasc Res. 2019;115:530–45. https://doi.org/10.1093/cvr/cvy217.
CAS Article PubMed Google Scholar
Zhou H, et al. Loss of high-temperature requirement protein A2 protease activity induces mitonuclear imbalance via differential regulation of mitochondrial biogenesis in sarcopenia. IUBMB Life. 2020;72:1659–79. https://doi.org/10.1002/iub.2289.
CAS Article PubMed Google Scholar
Melber A, et al. UPR(mt) regulation and output: a stress response mediated by mitochondrial-nuclear communication. Cell Res. 2018;28:281–95. https://doi.org/10.1038/cr.2018.16.
CAS Article PubMed PubMed Central Google Scholar
Houtkooper RH, et al. Mitonuclear protein imbalance as a conserved longevity mechanism. Nature. 2013;497:451–7. https://doi.org/10.1038/nature12188.
CAS Article PubMed PubMed Central Google Scholar
Haynes CM, et al. The mitochondrial UPR—protecting organelle protein homeostasis. J Cell Sci. 2010;123:3849–55. https://doi.org/10.1242/jcs.075119.
CAS Article PubMed Google Scholar
Moullan N, et al. Tetracyclines disturb mitochondrial function across eukaryotic models: a call for caution in biomedical research. Cell Rep. 2015;10:1681–91. https://doi.org/10.1016/j.celrep.2015.02.034.
CAS Article PubMed PubMed Central Google Scholar
English J, et al. Decoding the rosetta stone of mitonuclear communication. Pharmacol Res. 2020;161: 105161. https://doi.org/10.1016/j.phrs.2020.105161.
CAS Article PubMed PubMed Central Google Scholar
Lv H, et al. Isovitexin exerts anti-inflammatory and anti-oxidant activities on lipopolysaccharide-induced acute lung injury by inhibiting MAPK and NF-κB and activating HO-1/Nrf2 pathways. Int J Biol Sci. 2016;12:72–86. https://doi.org/10.7150/ijbs.13188.
CAS Article PubMed PubMed Central Google Scholar
Shi J, et al. PI3K/Akt pathway-mediated HO-1 induction regulates mitochondrial quality control and attenuates endotoxin-induced acute lung injury. Lab Invest. 2019;99:1795–809. https://doi.org/10.1038/s41374-019-0286-x.
CAS Article PubMed Google Scholar
Zhang L, et al. Isoflavone ME-344 disrupts redox homeostasis and mitochondrial function by targeting heme oxygenase 1. Cancer Res. 2019;79:4072–85. https://doi.org/10.1158/0008-5472.Can-18-3503.
CAS Article PubMed PubMed Central Google Scholar
Shi J, et al. Dexmedetomidine ameliorates endotoxin-induced acute lung injury in vivo and in vitro by preserving mitochondrial dynamic equilibrium through the HIF-1a/HO-1 signaling pathway. Redox Biol. 2021;41: 101954. https://doi.org/10.1016/j.redox.2021.101954.
CAS Article PubMed PubMed Central Google Scholar
Shi J, et al. Hydromorphone protects against CO(2) pneumoperitoneum-induced lung injury via heme oxygenase-1-regulated mitochondrial dynamics. Oxid Med Cell Longev. 2021;2021:9034376. https://doi.org/10.1155/2021/9034376.
CAS Article PubMed PubMed Central Google Scholar
Li X, et al. Heme oxygenase-1(HO-1) regulates Golgi stress and attenuates endotoxin-induced acute lung injury through hypoxia inducible factor-1α (HIF-1α)/HO-1 signaling pathway. Free Radical Biol Med. 2021;165:243–53. https://doi.org/10.1016/j.freeradbiomed.2021.01.028.
Bi XG, et al. Helix B surface peptide protects against acute lung injury through reducing oxidative stress and endoplasmic reticulum stress via activation of Nrf2/HO-1 signaling pathway. Eur Rev Med Pharmacol Sci. 2020;24:6919–30. https://doi.org/10.26355/eurrev_202006_21683.
Nikiforov A, et al. The human NAD metabolome: functions, metabolism and compartmentalization. Crit Rev Biochem Mol Biol. 2015;50:284–97. https://doi.org/10.3109/10409238.2015.1028612.
CAS Article PubMed PubMed Central Google Scholar
Zhang DX, et al. The potential regulatory roles of NAD(+) and its metabolism in autophagy. Metabolism. 2016;65:454–62. https://doi.org/10.1016/j.metabol.2015.11.010.
CAS Article PubMed Google Scholar
Cambronne XA, et al. Biosensor reveals multiple sources for mitochondrial NAD+. Science (New York, NY). 2016;352:1474–7. https://doi.org/10.1126/science.aad5168.
Hong G, et al. Administration of nicotinamide riboside prevents oxidative stress and organ injury in sepsis. Free Radical Biol Med. 2018;123:125–37. https://doi.org/10.1016/j.freeradbiomed.2018.05.073.
Tran MT, et al. PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection. Nature. 2016;531:528–32. https://doi.org/10.1038/nature17184.
CAS Article PubMed PubMed Central Google Scholar
Lee CF, et al. Normalization of NAD+ redox balance as a therapy for heart failure. Circulation. 2016;134:883–94. https://doi.org/10.1161/circulationaha.116.022495.
CAS Article PubMed PubMed Central Google Scholar
Wegiel B, et al. Heme oxygenase-1: a metabolic nike. Antioxid Redox Signal. 2014;20:1709–22. https://doi.org/10.1089/ars.2013.5667.
CAS Article PubMed PubMed Central Google Scholar
Vettorazzi S, et al. Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1. Nat Commun. 2015;6:7796. https://doi.org/10.1038/ncomms8796.
CAS Article PubMed Google Scholar
Ye Z, et al. LncRNA-LET inhibits cell growth of clear cell renal cell carcinoma by regulating miR-373-3p. Cancer Cell Int. 2019;19:311. https://doi.org/10.1186/s12935-019-1008-6.
CAS Article PubMed PubMed Central Google Scholar
Le Ribeuz H, et al. Proteomic analysis of KCNK3 loss of expression identified dysregulated pathways in pulmonary vascular cells. Int J Mol Sci. 2020. https://doi.org/10.3390/ijms21197400.
Article PubMed PubMed Central Google Scholar
Imai SI, et al. It takes two to tango: NAD(+) and sirtuins in aging/longevity control. NPJ Aging Mech Dis. 2016;2:16017. https://doi.org/10.1038/npjamd.2016.17.
留言 (0)