Clinical Study
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Di Lorenzo G. · Ingenito C. · D'Ambrosio B. · Ranieri C. · Iervolino M. · Primiano F. · Buonerba L. · Busto G. · Ferrara C. · Libroia A. · Ragone G. · De Falco F. · Costabile F. · Fimiani P. · Ugliano F. · Leo E. · Roviello G. · Scafuri L. · Buonerba C.Background The COICA study is an ambispective, observational trial that was conceived to assess the clinical course of SARS-CoV-2 infection in cancer patients. A recently published, population-based, case-control study reported a reduced vaccine efficacy at 3-6 months in cancer patients compared to individuals without cancer. Objectives To describe COVID-19 outcomes in cancer patients and analyze differences in SARS-CoV-2 outcomes between vaccinated and unvaccinated patients Methods Descriptive statistics and frequency counts were used to summarize characteristics of the study population. Chi-square test and the log-rank test were used to compare outcomes between vaccinated and unvaccinated patients. Results A total of 141 cancer patients (80 males, 61 females) were recruited at two participating Institutions since March, 2020 until April, 2022 and observed since the time of positive SARS-CoV-2 test to time of negativization or death. Approximately 35% of patients had been vaccinated at the time of infection with 2 (16 patients) or 3 ( 33 patients) vaccine doses. Vaccinated patients consistently and significantly showed improved COVID-19 outcomes compared to unvaccinated patients, with CT diagnosed pneumonia, hospitalization required, O2 required and death in 0% vs. 48.6%, 2.0% vs. 15.2%, 0% vs. 14.1%, 0% vs. 7.6%, respectively, of assessable patients (p
S. Karger AG, Basel
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