Role of sarcopenia in advanced malignant cutaneous melanoma treated with immunotherapy. A Meta Analysis

Clinical Study

Open Access Gateway Surov A. · Meyer H.-J. · Wienke A.
Abstract

Objectives: The role of sarcopenia in malignant cutaneous melanoma is unclear. The aim of the present meta analysis was to analyze the prevalence and clinical role of sarcopenia in patients with advanced cutaneous melanoma based on a large cohort. Methods: MEDLINE, Cochrane, and SCOPUS databases were checked for relationships between sarcopenia and clinical outcomes in melanoma up to September 2021. Overall, 6 studies including 719 patients met the inclusion criteria. The meta-analysis was peformed using RevMan 5.3 software. Results: The prevalence of sarcopenia was 40.23%. Sarcopenia did not influence dose limiting toxicity of treatment, HR 1.01, CI95% (0.70-1.47). Sarcopenia was associated with lower progression free survival (PFS): HR 1.49, CI95% (0.98–2.26), and lower overall survival (OS): HR 1.67, CI95% (1.11–2.52). Conclusions: The cumulative prevalence of sarcopenia in malignant cutaneous melanoma is 40.77%. Sarcopenia is slightly associated with PFS and OS and it is not associated with treatment toxicity.

The Author(s). Published by S. Karger AG, Basel

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