Markham JA, Juraska JM. Social recognition memory: influence of age, sex, and ovarian hormonal status. Physiol Behav. 2007;92(5):881–8.

CAS  PubMed  PubMed Central  Google Scholar 

McGraw LA, Young LJ. The prairie vole: an emerging model organism for understanding the social brain. Trends Neurosci. 2010;33(2):103–9.

CAS  PubMed  Google Scholar 

Okuyama T, Yokoi S, Abe H, Isoe Y, Suehiro Y, Imada H, et al. A neural mechanism underlying mating preferences for familiar individuals in medaka fish. Science. 2014;343(6166):91–4.

CAS  PubMed  Google Scholar 

Ferguson JN, Young LJ, Insel TR. The neuroendocrine basis of social recognition. Front Neuroendocrinol. 2002;23(2):200–24.

CAS  PubMed  Google Scholar 

Jacobs SA, Huang F, Tsien JZ, Wei W. Social recognition memory test in rodents. Bio Protoc. 2016;6:e1804.

Google Scholar 

de la Zerda SH, Netser S, Magalnik H, Briller M, Marzan D, Glatt S, et al. Social recognition in rats and mice requires integration of olfactory, somatosensory and auditory cues. Preprint at bioRxiv. 2020. https://doi.org/10.1101/2020.05.05.078139.

Kogan JH, Frankland PW, Silva AJ. Long-term memory underlying hippocampus-dependent social recognition in mice. Hippocampus. 2000;10(1):47–56.

CAS  PubMed  Google Scholar 

Suzuki A, Fukushima H, Mukawa T, Toyoda H, Wu LJ, Zhao MG, et al. Upregulation of CREB-mediated transcription enhances both short- and long-term memory. J Neurosci. 2011;31(24):8786–802.

CAS  PubMed  PubMed Central  Google Scholar 

Hitti FL, Siegelbaum SA. The hippocampal CA2 region is essential for social memory. Nature. 2014;508(7494):88–92.

CAS  PubMed  PubMed Central  Google Scholar 

Garrido Zinn C, Clairis N, Silva Cavalcante LE, Furini CR, et al. Major neurotransmitter systems in dorsal hippocampus and basolateral amygdala control social recognition memory. Proc Natl Acad Sci USA. 2016;113(33):E4914–9.

PubMed  PubMed Central  Google Scholar 

Tanimizu T, Kenney JW, Okano E, Kadoma K, Frankland PW, Kida S. Functional connectivity of multiple brain regions required for the consolidation of social recognition memory. J Neurosci. 2017;37(15):4103–16.

CAS  PubMed  PubMed Central  Google Scholar 

Lin YT, Hsieh TY, Tsai TC, Chen CC, Huang CC, Hsu KS. Conditional deletion of hippocampal CA2/CA3a oxytocin receptors impairs the persistence of long-term social recognition memory in mice. J Neurosci. 2018;38(5):1218–31.

CAS  PubMed  PubMed Central  Google Scholar 

Meira T, Leroy F, Buss EW, Oliva A, Park J, Siegelbaum SA. A hippocampal circuit linking dorsal CA2 to ventral CA1 critical for social memory dynamics. Nat Commun. 2018;9(1):4163.

PubMed  PubMed Central  Google Scholar 

Stevenson EL, Caldwell HK. Lesions to the CA2 region of the hippocampus impair social memory in mice. Eur J Neurosci. 2014;40(9):3294–301.

PubMed  PubMed Central  Google Scholar 

Okuyama T, Kitamura T, Roy DS, Itohara S, Tonegawa S. Ventral CA1 neurons store social memory. Science. 2016;353(6307):1536–41.

CAS  PubMed  PubMed Central  Google Scholar 

Jurek B, Neumann ID. The oxytocin receptor: from intracellular signaling to behavior. Physiol Rev. 2018;98(3):1805–908.

CAS  PubMed  Google Scholar 

Froemke RC, Young LJ. Oxytocin, neural plasticity, and social behavior. Annu Rev Neurosci. 2021;44:359–81.

CAS  PubMed  PubMed Central  Google Scholar 

Mitre M, Kranz TM, Marlin BJ, Schiavo JK, Erdjument-Bromage H, Zhang X, et al. Sex-specific differences in oxytocin receptor expression and function for parental behavior. Gend Genome. 2017;1(4):142–66.

PubMed  PubMed Central  Google Scholar 

Grinevich V, Stoop R. Interplay between oxytocin and sensory systems in the orchestration of socio-emotional behaviors. Neuron. 2018;99(5):887–904.

CAS  PubMed  Google Scholar 

Zhang J, Li SJ, Miao W, Zhang X, Zheng JJ, Wang C, et al. Oxytocin regulates synaptic transmission in the sensory cortices in a developmentally dynamic manner. Front Cell Neurosci. 2021;15:673439.

CAS  PubMed  PubMed Central  Google Scholar 

Raam T, McAvoy KM, Besnard A, Veenema AH, Sahay A. Hippocampal oxytocin receptors are necessary for discrimination of social stimuli. Nat Commun. 2017;8(1):2001.

PubMed  PubMed Central  Google Scholar 

Chiang MC, Huang AJY, Wintzer ME, Ohshima T, McHugh TJ. A role for CA3 in social recognition memory. Behav Brain Res. 2018;354:22–30.

CAS  PubMed  Google Scholar 

Yoshida M, Takayanagi Y, Inoue K, Kimura T, Young LJ, Onaka T, et al. Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice. J Neurosci. 2009;29(7):2259–71.

CAS  PubMed  PubMed Central  Google Scholar 

Lin YT, Chen CC, Huang CC, Nishimori K, Hsu KS. Oxytocin stimulates hippocampal neurogenesis via oxytocin receptor expressed in CA3 pyramidal neurons. Nat Commun. 2017;8(1):537.

PubMed  PubMed Central  Google Scholar 

Karlsson SA, Haziri K, Hansson E, Kettunen P, Westberg L. Effects of sex and gonadectomy on social investigation and social recognition in mice. BMC Neurosci. 2015;16:83.

PubMed  PubMed Central  Google Scholar 

Krueger-Burg D, Winkler D, Mitkovski M, Daher F, Ronnenberg A, Schlüter OM, Dere E, Ehrenreich H. The socioBox: a novel paradigm to assess complex social recognition in male mice. Front Behav Neurosci. 2016;10:151.

PubMed  PubMed Central  Google Scholar 

Stachniak TJ, Ghosh A, Sternson SM. Chemogenetic synaptic silencing of neural circuits localizes a hypothalamus→midbrain pathway for feeding behavior. Neuron. 2014;82(4):797–808.

CAS  PubMed  PubMed Central  Google Scholar 

Chiou CS, Chen CC, Tsai TC, Huang CC, Chou D, Hsu KS. Alleviating bone cancer-induced mechanical hypersensitivity by inhibiting neuronal activity in the anterior cingulate cortex. Anesthesiology. 2016;125(4):779–92.

PubMed  Google Scholar 

Shinohara Y, Hosoya A, Yahagi K, Ferecskó AS, Yaguchi K, Sík A, et al. Hippocampal CA3 and CA2 have distinct bilateral innervation patterns to CA1 in rodents. Eur J Neurosci. 2012;35(5):702–10.

PubMed  Google Scholar 

Kohara K, Pignatelli M, Rivest AJ, Jung HY, Kitamura T, Suh J, et al. Cell type-specific genetic and optogenetic tools reveal hippocampal CA2 circuits. Nat Neurosci. 2014;17(2):269–79.

CAS  PubMed  Google Scholar 

Leroy F, Park J, Asok A, Brann DH, Meira T, Boyle LM, et al. A circuit from hippocampal CA2 to lateral septum disinhibits social aggression. Nature. 2018;564(7735):213–8.

CAS  PubMed  PubMed Central  Google Scholar 

Moy SS, Nadler JJ, Perez A, Barbaro RP, Johns JM, Magnuson TR, et al. Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice. Genes Brain Behav. 2004;3(5):287–302.

CAS  PubMed  Google Scholar 

Ferretti V, Maltese F, Contarini G, Nigro M, Bonavia A, Huang H, et al. Oxytocin signaling in the central amygdala modulates emotion discrimination in mice. Curr Biol. 2019;29(12):1938–53.

CAS  PubMed  Google Scholar 

Tirko NN, Eyring KW, Carcea I, Mitre M, Chao MV, Froemke RC, et al. Oxytocin transforms firing mode of CA2 hippocampal neurons. Neuron. 2018;100(3):593–608.

CAS  PubMed  PubMed Central  Google Scholar 

Gur R, Tendler A, Wagner S. Long-term social recognition memory is mediated by oxytocin-dependent synaptic plasticity in the medial amygdala. Biol Psychiatry. 2014;76(5):377–86.

CAS  PubMed  Google Scholar 

Bluthé RM, Gheusi G, Dantzer R. Gonadal steroids influence the involvement of arginine vasopressin in social recognition in mice. Psychoneuroendocrinology. 1993;18(4):323–35.

PubMed  Google Scholar 

Smith AS, Williams Avram SK, Cymerblit-Sabba A, Song J, Young WS. Targeted activation of the hippocampal CA2 area strongly enhances social memory. Mol Psychiatry. 2016;21(8):1137–44.

CAS  PubMed  PubMed Central  Google Scholar 

Shahar-Gold H, Gur R, Wagner S. Rapid and reversible impairments of short- and long-term social recognition memory are caused by acute isolation of adult rats via distinct mechanisms. PLoS ONE. 2013;8(5):e65085.

CAS  PubMed  PubMed Central  Google Scholar 

Tzakis N, Holahan MR. Social memory and the role of the hippocampal CA2 region. Front Behav Neurosci. 2019;13:233.

CAS  PubMed  PubMed Central  Google Scholar 

Benoy A, Dasgupta A, Sajikumar S. Hippocampal area CA2: an emerging modulatory gateway in the hippocampal circuit. Exp Brain Res. 2018;236(4):919–31.

CAS  PubMed  Google Scholar 

Lehr AB, Kumar A, Tetzlaff C, Hafting T, Fyhn M, Stöber TM. CA2 beyond social memory: evidence for a fundamental role in hippocampal information processing. Neurosci Biobehav Rev. 2021;126:398–412.

CAS  PubMed  Google Scholar 

Laeremans A, Nys J, Luyten W, D’Hooge R, Paulussen M, Arckens L. AMIGO2 mRNA expression in hippocampal CA2 and CA3a. Brain Struct Funct. 2013;218(1):123–30.

CAS  PubMed  Google Scholar 

Ferguson JN, Young LJ, Hearn EF, Matzuk MM, Insel TR, Winslow JT. Social amnesia in mice lacking the oxytocin gene. Nat Genet. 2000;25(3):284–8.

CAS  PubMed