Rosenblum MD, Remedios KA, Abbas AK. Mechanisms of human autoimmunity. J Clin Investig. 2015;125:2228–33.
PubMed PubMed Central Article Google Scholar
Research IoMCoWsH. Women’s health research: progress, pitfalls, and promise. Washington, DC: National Academies Press; 2010.
Tavakolpour S. Towards personalized medicine for patients with autoimmune diseases: opportunities and challenges. Immunol Lett. 2017;190:130–8.
CAS PubMed Article Google Scholar
O’prey J, Brown J, Fleming J, Harrison PR. Effects of dietary flavonoids on major signal transduction pathways in human epithelial cells. Biochem Pharmacol. 2003;66:2075–88.
PubMed Article CAS Google Scholar
Kumar S, Pandey AK. Chemistry and biological activities of flavonoids: an overview. Sci World J. 2013; 2013.
Faramarzi F, Alimohammadi M, Rahimi A, Alizadeh-Navaei R, Shakib RJ, Rafiei A. Naringenin induces intrinsic and extrinsic apoptotic signaling pathways in cancer cells: A systematic review and meta-analysis of in vitro and in vivo data. Nutr Res. 2022. https://doi.org/10.1016/j.nutres.2022.05.003.
Gutierrez-Merino C, Lopez-Sanchez C, Lagoa R, Samhan-Arias AK, Bueno C, Garcia-Martinez V. Neuroprotective actions of flavonoids. Curr Med Chem. 2011;18:1195–212.
CAS PubMed Article Google Scholar
Lee H, Kim YO, Kim H, Kim SY, Noh HS, Kang SS, et al. Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia. FASEB J. 2003;17:1–21.
Park S, Sapkota K, Kim S, Kim H, Kim S. Kaempferol acts through mitogen-activated protein kinases and protein kinase B/AKT to elicit protection in a model of neuroinflammation in BV2 microglial cells. Br J Pharmacol. 2011;164:1008–25.
CAS PubMed PubMed Central Article Google Scholar
Sternberg Z, Chadha K, Lieberman A, Drake A, Hojnacki D, Weinstock-Guttman B, et al. Immunomodulatory responses of peripheral blood mononuclear cells from multiple sclerosis patients upon in vitro incubation with the flavonoid luteolin: additive effects of IFN-β. J Neuroinflammation. 2009;6:1–8.
Rodriguez-Canales M, Martinez-Galero E, Nava-Torres AD, Sanchez-Torres LE, Garduño-Siciliano L, Canales-Martinez MM, et al. Anti-Inflammatory and antioxidant activities of the methanolic extract of Cyrtocarpa procera bark reduces the severity of ulcerative colitis in a chemically induced colitis model. Mediators Inflamm. 2020;2020:1–11.
Manchope MF, Artero NA, Fattori V, Mizokami SS, Pitol DL, Issa JP, et al. Naringenin mitigates titanium dioxide (TiO 2)-induced chronic arthritis in mice: role of oxidative stress, cytokines, and NFκB. Inflamm Res. 2018;67:997–1012.
CAS PubMed Article Google Scholar
Al-Rejaie SS, Abuohashish HM, Al-Enazi MM, Al-Assaf AH, Parmar MY, Ahmed MM. Protective effect of naringenin on acetic acid-induced ulcerative colitis in rats. World J Gastroenterol: WJG. 2013;19:5633.
CAS PubMed PubMed Central Article Google Scholar
Fan R, Pan T, Zhu A-L, Zhang M-H. Anti-inflammatory and anti-arthritic properties of naringenin via attenuation of NF-κB and activation of the heme oxygenase (HO)-1/related factor 2 pathway. Pharmacol Rep. 2017;69:1021–9.
CAS PubMed Article Google Scholar
Wang J, Qi Y, Niu X, Tang H, Meydani SN, Wu D. Dietary naringenin supplementation attenuates experimental autoimmune encephalomyelitis by modulating autoimmune inflammatory responses in mice. J Nutr Biochem. 2018;54:130–9.
CAS PubMed Article Google Scholar
Abrego-Peredo A, Romero-Ramirez H, Espinosa E, Lopez-Herrera G, Garcia-Garcia F, Flores-Munoz M, et al. Naringenin mitigates autoimmune features in lupus-prone mice by modulation of T-cell subsets and cytokines profile. PLoS ONE. 2020;15: e0233138.
CAS PubMed PubMed Central Article Google Scholar
Wojnar W, Zych M, Kaczmarczyk-Sedlak I. Antioxidative effect of flavonoid naringenin in the lenses of type 1 diabetic rats. Biomed Pharmacother. 2018;108:974–84.
CAS PubMed Article Google Scholar
Li Y-R, Chen D-Y, Chu C-L, Li S, Chen Y-K, Wu C-L, et al. Naringenin inhibits dendritic cell maturation and has therapeutic effects in a murine model of collagen-induced arthritis. J Nutr Biochem. 2015;26:1467–78.
CAS PubMed Article Google Scholar
Naeini F, Namkhah Z, Ostadrahimi A, Tutunchi H, Hosseinzadeh-Attar MJ. A comprehensive systematic review of the effects of naringenin, a citrus-derived flavonoid, on risk factors for nonalcoholic fatty liver disease. Adv Nutr. 2021;12:413–28.
Rahimi A, Alimohammadi M, Faramarzi F, Alizadeh-Navaei R, Rafiei A. The effects of apigenin administration on the inhibition of inflammatory responses and oxidative stress in the lung injury models: a systematic review and meta-analysis of preclinical evidence. Inflammopharmacology. 2022. https://doi.org/10.1007/s10787-022-00994-0.
Liberati A, Altman D, Tetzlaff J. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. BMJ. 2009; 339.
Hooijmans CR, Rovers MM, de Vries R, Leenaars M, Ritskes-Hoitinga M, Langendam MW. SYRCLE’s risk of bias tool for animal studies. BMC Med Res Methodol. 2014;14:1–9.
Amaro MI, Rocha J, Vila-Real H, Eduardo-Figueira M, Mota-Filipe H, Sepodes B, et al. Anti-inflammatory activity of naringin and the biosynthesised naringenin by naringinase immobilized in microstructured materials in a model of DSS-induced colitis in mice. Food Res Int. 2009;42:1010–7.
Chaen Y, Yamamoto Y, Suzuki T. Naringenin promotes recovery from colonic damage through suppression of epithelial tumor necrosis factor–α production and induction of M2-type macrophages in colitic mice. Nutr Res. 2019;64:82–92.
CAS PubMed Article Google Scholar
Dou W, Zhang J, Sun A, Zhang E, Ding L, Mukherjee S, et al. Protective effect of naringenin against experimental colitis via suppression of Toll-like receptor 4/NF-κB signalling. Br J Nutr. 2013;110:599–608.
CAS PubMed PubMed Central Article Google Scholar
Hajizadeh A, Abtahi Froushani S, Tehrani A, Azizi S, Bani Hashemi S. Effects of Naringenin on experimental rheumatoid arthritis in Wistar rats. Archives of Razi Institute; 2020.
Wang J, Wei T, Gao J, He H, Chang X, Yan T. Effects of Naringenin on inflammation in complete freund’s adjuvant-induced arthritis by regulating Bax/Bcl-2 balance. Inflammation. 2015;38:245–51.
PubMed Article CAS Google Scholar
Niu X, Sang H, Wang J. Naringenin attenuates experimental autoimmune encephalomyelitis by protecting the intact of blood-brain barrier and controlling inflammatory cell migration. J Nutr Biochem. 2021;89: 108560.
CAS PubMed Article Google Scholar
Gupta SC, Tyagi AK, Deshmukh-Taskar P, Hinojosa M, Prasad S, Aggarwal BB. Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols. Arch Biochem Biophys. 2014;559:91–9.
CAS PubMed Article Google Scholar
Jin L, Zeng W, Zhang F, Zhang C, Liang W. Naringenin ameliorates acute inflammation by regulating intracellular cytokine degradation. J Immunol. 2017;199:3466–77.
CAS PubMed Article Google Scholar
Du G, Jin L, Han X, Song Z, Zhang H, Liang W. Naringenin: a potential immunomodulator for inhibiting lung fibrosis and metastasis. Can Res. 2009;69:3205–12.
Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH. Mechanisms underlying inflammation in neurodegeneration. Cell. 2010;140:918–34.
CAS PubMed PubMed Central Article Google Scholar
Pinho-Ribeiro FA, Zarpelon AC, Mizokami SS, Borghi SM, Bordignon J, Silva RL, et al. The citrus flavonone naringenin reduces lipopolysaccharide-induced inflammatory pain and leukocyte recruitment by inhibiting NF-κB activation. J Nutr Biochem. 2016;33:8–14.
CAS PubMed Article Google Scholar
Yoshida H, Watanabe W, Oomagari H, Tsuruta E, Shida M, Kurokawa M. Citrus flavonoid naringenin inhibits TLR2 expression in adipocytes. J Nutr Biochem. 2013;24:1276–84.
CAS PubMed Article Google Scholar
Pinho-Ribeiro FA, Zarpelon AC, Fattori V, Manchope MF, Mizokami SS, Casagrande R, et al. Naringenin reduces inflammatory pain in mice. Neuropharmacology. 2016;105:508–19.
CAS PubMed Article Google Scholar
Manchope MF, Calixto-Campos C, Coelho-Silva L, Zarpelon AC, Pinho-Ribeiro FA, Georgetti SR, et al. Naringenin inhibits superoxide anion-induced inflammatory pain: role of oxidative stress, cytokines, Nrf-2 and the NO− cGMP− PKG− KATPChannel signaling pathway. PLoS ONE. 2016;11: e0153015.
PubMed PubMed Central Article CAS Google Scholar
Martinez RM, Pinho-Ribeiro FA, Steffen VS, Caviglione CV, Vignoli JA, Barbosa DS, et al. Naringenin inhibits UVB irradiation-induced inflammation and oxidative stress in the skin of hairless mice. J Nat Prod. 2015;78:1647–55.
CAS PubMed Article Google Scholar
Hämäläinen M, Nieminen R, Vuorela P, Heinonen M, Moilanen E. Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-κB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-κB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediat Inflamm 2007; 2007.
Smith AM, Rahman FZ, Hayee BH, Graham SJ, Marks DJ, Sewell GW, et al. Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn’s disease. J Exp Med. 2009;206:1883–97.
CAS PubMed PubMed Central Article Google Scholar
Zeng W, Jin L, Zhang F, Zhang C, Liang W. Naringenin as a potential immunomodulator in therapeutics. Pharmacol Res. 2018;135:122–6.
CAS PubMed Article Google Scholar
Hartmann RM, Martins MIM, Tieppo J, Fillmann HS, Marroni NP. Effect of Boswellia serrata on antioxidant status in an experimental model of colitis rats induced by acetic acid. Dig Dis Sci. 2012;57:2038–44.
留言 (0)