The strategic roles of four enzymes in the interconnection between metabolism and oncogene activation in non-small cell lung cancer: therapeutic implications

ACC

Acetyl-CoA carboxylase

ACSL

Acyl-coenzyme A synthetase long-chain isoform

ACSS2

Acetyl-CoA synthetase 2

ASCT2/ SLC1A5

Alanine serine cysteine preferring transporter 2

ATP

Adenosine triphosphate

ALK

Anaplastic lymphoma kinase

BRAF

V-raf murine sarcoma viral oncogene homolog B1

CDK

Cyclin-dependent kinase

CPS1

Carbamoyl phosphate synthetase-1

DHAP

Dihydroxyacetone phosphate

DHODH

Dihydroorotate dehydrogenase

E2F1

E2F Transcription Factor 1

EGF

Epidermal Growth Factor

EGFR

Epidermal Growth Factor Receptor

EMT

Epithelial to mesenchymal transition

ERBB2

Erythroblastic oncogene B

ERK

Ras-dependent extracellular signal-regulated kinase

EZH2

Enhancer of zeste homologue 2

F-1,6-BP

Fructose-1,6-bisphosphate

F-2,6-BP

Fructose-2,6-bisphosphate

FBPase1

Fructose-1,6-bisphosphatase 1

18F-FDG

18F-fluoro-Deoxy-glucose

FGF-β

Fibroblast growth factor-β

FGFR1

Fibroblast growth factor receptor type 1

G3P

Glyceraldehyde 3-phosphate

GAPDH

Glyceraldehyde-3-phosphate dehydrogenase

GCN5

General control non-depressible 5

GLUD

Glutamate dehydrogenase

GOT1

Glutamic-oxaloacetic transaminase 1

GTP

Guanosine triphosphate

HBP

Hexosamine biosynthesis pathway

HER2

Human epidermal growth factor receptor 2

HGF

Hepatocyte growth factor

HIF-1α

Hypoxia‑induced factor‑1α

HMG-CoA

3-hydroxy-3-methyl-glutaryl-CoA

IDH

Isocitrate dehydrogenase

IGFR

Insulin-like growth factor receptor

IL-6R

Interleukin-6 receptor

KRAS

Kristen rat sarcoma viral oncogene homolog

LDHA

Lactate dehydrogenase A

LSCC

Lung squamous-cell carcinoma

MAPK

Mitogen-activated protein kinase

MCT4

Monocarboxylate transporter 4

mTOR

Mammalian target of rapamycin

MUFA

Monounsaturated fatty acid

NAD+

Nicotinamide adenine dinucleotide

NADPH

H+, Nicotinamide adenine dinucleotide phosphate

NSCLC

Non-small cell lung carcinoma

OXPHOS

Oxidative phosphorylation

PARP

Poly (ADP-ribose) polymerase

PD-1

Programmed cell Death death-1

PDH

Pyruvate dehydrogenase

PDK1

Pyruvate dehydrogenase kinase 1

PD-L1

Programmed death ligand 1

PET/CT

Positron emission computed tomography

PFK1/ PFKP

Phosphofructokinase 1

PFK2/ PFKFB3

Phosphofructokinase 2

PGK1

Phosphoglycerate kinase 1

PI3K

Phosphatidylinositol-3-kinase

PI3P

Phosphatidylinositol 3-phosphate

PKM2

Pyruvate kinase muscle embryonic isozyme 2

PPAT

Phosphoribosyl pyrophosphate amidotransferase

PPP

Pentose phosphate pathway

PTEN

Phosphatase and tensin homolog deleted on chromosome 10

PUFA

Polyunsaturated fatty acid

RALGDS

Ral guanine nucleotide dissociation stimulator

RIP

Receptor Interacting Protein kinase

S1P

Sphingosine-1-phosphate

SCLC

Small cell lung cancer

SDH

Succinate dehydrogenase

SOS1

Son of sevenless homolog 1

SphK2

Sphingosine kinase 2

SREBP1

Sterol regulatory element-binding protein

STAT

Signal transducers and activators of transcription

TGF

Transforming growth factor

TGFBR2

Transforming growth factor-β receptor 2

TKIs

Tyrosine kinase inhibitors

TKTL1

Transketolase-like 1

TME

Tumor microenvironment

TP53

Transformation-related protein 53

VEGF

Vascular endothelial growth factor

YAP/TAZ

Yes-associated protein/transcription co-activator

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