Moore AM, Mathias M, Valeur J (2018) Contextualising the microbiota-gut-brain axis in history and culture. Microbial Ecol Health Dis 30:1546267

Article  Google Scholar 

Miller I (2015) A modern history of the stomach: gastric illness, medicine and British society, 1800–1950: Routledge

Forth CE, Carden-Coyne A (2005) Cultures of the abdomen: diet, digestion, and fat in the modern world: Springer

King LS (1970) Robert Whytt, the Soul, and Medicine. JAMA 211: 303-

Weisz G (2003) The emergence of medical specialization in the nineteenth century. Bull Hist Med 77:536–575

PubMed  Article  Google Scholar 

Baicus A (2012) History of polio vaccination. World J Virol 1:108–114

PubMed  PubMed Central  Article  Google Scholar 

Cotton P (2014) A history of luminal gastroenterology in Britain: the inside guide. BMJ Publishing Group

Koch R (1890) An address on bacteriological research. Br Med J 2:380–383

CAS  PubMed  PubMed Central  Article  Google Scholar 

Jakovljevic MB, Milovanovic O (2015) Growing burden of non-communicable diseases in the emerging health markets: the case of BRICS. Front Publ Health 3: 65

Ayub A, Faloon WW, Heinig RE (1981) Encephalopathy following jejunoileostomy. Jama 246:970–973

CAS  PubMed  Article  Google Scholar 

Mackowiak PA (2013) Recycling metchnikoff: probiotics, the intestinal microbiome and the quest for long life. Front Public Health 1:52

PubMed  PubMed Central  Article  Google Scholar 

Rowland IR, Davies MJ, Evans JG (1980) Tissue content of mercury in rats given methylmercuric chloride orally: influence of intestinal flora. Arch Environ Health 35:155–160

CAS  PubMed  Article  Google Scholar 

Sandler M, Karoum F, Ruthven CR, Calne DB (1969) m-Hydroxyphenylacetic acid formation from L-dopa in man: suppression by neomycin. Science 166:1417–1418

CAS  PubMed  Article  Google Scholar 

Fischer JE, James JH, Baldessarini R (1972) Changes in brain amines following portal flow diversion and acute hepatic coma: effects of levodopa (L-dopa) and intestinal sterilization. Surg Forum 23:348–350

CAS  PubMed  Google Scholar 

Hegstrand LR, Hine RJ (1986) Variations of brain histamine levels in germ-free and nephrectomized rats. Neurochem Res 11:185–191

CAS  PubMed  Article  Google Scholar 

Philbert MA, Gray AJ, Connors TA (1987) Preliminary investigations into the involvement of the intestinal microflora in CNS toxicity induced by 1,3-dinitrobenzene in male F-344 rats. Toxicol Lett 38:307–314

CAS  PubMed  Article  Google Scholar 

Macbeth WA, Kass EH, McDermott WV Jr (1965) Treatment of hepatic encephalopathy by alteration of intestinal flora with Lactobacillus acidophilus. Lancet 1:399–403

CAS  PubMed  Article  Google Scholar 

Kipnis J, Cohen H, Cardon M, Ziv Y, Schwartz M (2004) T cell deficiency leads to cognitive dysfunction: implications for therapeutic vaccination for schizophrenia and other psychiatric conditions. Proc Natl Acad Sci 101:8180–8185

CAS  PubMed  PubMed Central  Article  Google Scholar 

Moalem G, Leibowitz-Amit R, Yoles E, Mor F, Cohen IR, Schwartz M (1999) Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy. Nat Med 5:49–55

CAS  PubMed  Article  Google Scholar 

Schwartz M, Peralta Ramos JM, Ben-Yehuda H (2020) A 20-year journey from axonal injury to neurodegenerative diseases and the prospect of immunotherapy for combating Alzheimer’s disease. J Immunol 204:243

CAS  PubMed  Article  Google Scholar 

Ziv Y, Ron N, Butovsky O, Landa G, Sudai E, Greenberg N, Cohen H, Kipnis J, Schwartz M (2006) Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood. Nat Neurosci 9:268–275

CAS  PubMed  Article  Google Scholar 

Ben-Nun A, Cohen IR (1981) Vaccination against autoimmune encephalomyelitis (EAE): attenuated autoimmune T lymphocytes confer resistance to induction of active EAE but not to EAE mediated by the intact T lymphocyte line. Eur J Immunol 11:949–952

CAS  PubMed  Article  Google Scholar 

Vandenbark AA, Hashim G, Offner H (1989) Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis. Nature 341:541–544

CAS  PubMed  Article  Google Scholar 

Huh GS, Boulanger LM, Du H, Riquelme PA, Brotz TM, Shatz CJ (2000) Functional requirement for class I MHC in CNS development and plasticity. Science 290:2155–2159

CAS  PubMed  PubMed Central  Article  Google Scholar 

Nutma E, Willison H, Martino G, Amor S (2019) Neuroimmunology - the past, present and future. Clin Exp Immunol 197:278–293

CAS  PubMed  PubMed Central  Article  Google Scholar 

Dougherty PM, Dafny N (1988) Neuroimmune intercommunication, central opioids, and the immune response to bacterial endotoxin. J Neurosci Res 19:140–148

CAS  PubMed  Article  Google Scholar 

Dougherty PM, Drath DB, Dafny N (1987) Evidence of an immune system to brain communication axis that affects central opioid functions: muramyl peptides attenuate opiate withdrawal. Eur J Pharmacol 141:253–260

CAS  PubMed  Article  Google Scholar 

Nadeau S, Rivest S (1999) Regulation of the gene encoding tumor necrosis factor alpha (TNF-alpha) in the rat brain and pituitary in response in different models of systemic immune challenge. J Neuropathol Exp Neurol 58:61–77

CAS  PubMed  Article  Google Scholar 

Baciu I, Olteanu A, Prodan T, Băiescu M, Vaida A (1988) Changes of phagocytic biological rhythm by reduction of circadian times and by influences upon hypothalamus. Int J Neurosci 41:143–153

CAS  PubMed  Article  Google Scholar 

Byndloss MX, Bäumler AJ (2018) The germ-organ theory of non-communicable diseases. Nat Rev Microbiol 16:103–110

CAS  PubMed  Article  Google Scholar 

Taché Y, Bernstein CN (2009) Evidence for the role of the brain-gut axis in inflammatory bowel disease: depression as cause and effect? Gastroenterology 136:2058

PubMed  Article  CAS  Google Scholar 

Wouters MM, Van Wanrooy S, Nguyen A, Dooley J, Aguilera-Lizarraga J, Van Brabant W, Garcia-Perez JE, Van Oudenhove L, Van Ranst M, Verhaegen J (2016) Psychological comorbidity increases the risk for postinfectious IBS partly by enhanced susceptibility to develop infectious gastroenteritis. Gut 65:1279–1288

CAS  PubMed  Article  Google Scholar 

Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, Codelli JA, Chow J, Reisman SE, Petrosino JF, Patterson PH, Mazmanian SK (2013) Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell 155:1451–1463

CAS  PubMed  PubMed Central  Article  Google Scholar 

Olson CA, Vuong HE, Yano JM, Liang QY, Nusbaum DJ, Hsiao EY (2018) The gut microbiota mediates the anti-seizure effects of the ketogenic diet. Cell 173:1728–41.e13

CAS  PubMed  PubMed Central  Article  Google Scholar 

Jacobson A, Yang D, Vella M, Chiu IM (2021) The intestinal neuro-immune axis: crosstalk between neurons, immune cells, and microbes. Mucosal Immunol 14:555–565

CAS  PubMed  PubMed Central  Article  Google Scholar 

Fung TC, Olson CA, Hsiao EY (2017) Interactions between the microbiota, immune and nervous systems in health and disease. Nat Neurosci 20:145–155

CAS  PubMed  PubMed Central  Article  Google Scholar 

Maes M (1995) Evidence for an immune response in major depression: a review and hypothesis. Prog Neuropsychopharmacol Biol Psychiatry 19:11–38

CAS  PubMed  Article  Google Scholar 

Miller BJ, Buckley P, Seabolt W, Mellor A, Kirkpatrick B (2011) Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects. Biol Psychiatry 70:663–671

CAS  PubMed  PubMed Central  Article  Google Scholar 

Monji A, Kato TA, Mizoguchi Y, Horikawa H, Seki Y, Kasai M, Yamauchi Y, Yamada S, Kanba S (2013) Neuroinflammation in schizophrenia especially focused on the role of microglia. Prog Neuropsychopharmacol Biol Psychiatry 42:115–121

CAS  PubMed  Article  Google Scholar 

Zhang W, Wang T, Pei Z, Miller DS, Wu X, Block ML, Wilson B, Zhang W, Zhou Y, Hong JS, Zhang J (2005) Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson’s disease. Faseb j 19:533–542

CAS  PubMed  Article  Google Scholar 

Kim YS, Joh TH (2006) Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson’s disease. Exp Mol Med 38:333–347

CAS  PubMed  Article  Google Scholar 

Koenigsknecht-Talboo J, Meyer-Luehmann M, Parsadanian M, Garcia-Alloza M, Finn MB, Hyman BT, Bacskai BJ, Holtzman DM (2008) Rapid microglial response around amyloid pathology after systemic anti-Abeta antibody administration in PDAPP mice. J Neurosci 28:14156–14164

CAS  PubMed