Hypertensive disorders in pregnancy affect approximately 10% of all pregnancies worldwide [[1], [2]]. Accurate assessment of blood pressure is essential, simple, cost-effective, and life-saving approach for proper obstetrical care in the management of hypertensive disorders in pregnancy [3]. Current clinical guidelines classify hypertensive disorders in pregnancy as chronic hypertension, white-coat hypertension, masked hypertension, gestational hypertension, transient gestational hypertension, de novo preeclampsia, and superimposed preeclampsia [[3], [4]]. Hypertensive complications during pregnancy represent one of the leading causes of perinatal mortality for mother and child [5]. Preeclampsia is the third leading cause of maternal mortality worldwide mostly, in low- and mid-income countries. In contrast, in developed countries, preeclampsia represents the most frequently cited indication for provider-initiated preterm birth [6]. The clinical guidelines provide appropriate recommendations concerning the management of severe and non-severe hypertension in pregnancy [[4], [7], [8]]. Although the current research is intensive, only limited prophylactic measures (low-dose aspirin) are applicable for preeclampsia, as the most severe representant of hypertensive disorders in pregnancy [9]. Nevertheless, if not treated, hypertension in pregnancy can result in detrimental events for both the mother and the child [10]. Flavonoids represent a class of bioactive phytochemicals exerting various biological activities, including the efficacy in the management of blood pressure as well as potent anti-inflammatory, immunomodulatory, antioxidant, and organ-protective activities [[11], [12], [13], [14], [15], [16], [17]]. Based on the biological activity of flavonoids and/or flavonoid-rich plants, we assume potential benefits of flavonoids to treat or prevent hypertensive disorders in pregnancy.
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