Calderon, L. & Boehm, T. Three chemokine receptors cooperatively regulate homing of hematopoietic progenitors to the embryonic mouse thymus. Proc. Natl Acad. Sci. USA 108, 7517–7522 (2011).
CAS PubMed PubMed Central Article Google Scholar
Plotkin, J., Prockop, S. E., Lepique, A. & Petrie, H. T. Critical role for CXCR4 signaling in progenitor localization and T cell differentiation in the postnatal thymus. J. Immunol. 171, 4521–4527 (2003).
CAS PubMed Article Google Scholar
Kadakia, T. et al. E-protein-regulated expression of CXCR4 adheres preselection thymocytes to the thymic cortex. J. Exp. Med. 216, 1749–1761 (2019).
CAS PubMed PubMed Central Article Google Scholar
Kurobe, H. et al. CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance. Immunity 24, 165–177 (2006).
CAS PubMed Article Google Scholar
Misslitz, A. et al. Thymic T cell development and progenitor localization depend on CCR7. J. Exp. Med. 200, 481–491 (2004).
CAS PubMed PubMed Central Article Google Scholar
Choi, Y. I. et al. PlexinD1 glycoprotein controls migration of positively selected thymocytes into the medulla. Immunity 29, 888–898 (2008).
CAS PubMed PubMed Central Article Google Scholar
Uehara, S., Grinberg, A., Farber, J. M. & Love, P. E. A role for CCR9 in T lymphocyte development and migration. J. Immunol. 168, 2811–2819 (2002).
CAS PubMed Article Google Scholar
Wurbel, M. A. et al. Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor γδ+ gut intraepithelial lymphocytes. Blood 98, 2626–2632 (2001).
CAS PubMed Article Google Scholar
Wurbel, M. A., Malissen, B. & Campbell, J. J. Complex regulation of CCR9 at multiple discrete stages of T cell development. Eur. J. Immunol. 36, 73–81 (2006).
CAS PubMed Article Google Scholar
Krishnamoorthy, V. et al. Repression of Ccr9 transcription in mouse T lymphocyte progenitors by the Notch signaling pathway. J. Immunol. 194, 3191–3200 (2015).
CAS PubMed Article Google Scholar
Ohoka, Y., Yokota, A., Takeuchi, H., Maeda, N. & Iwata, M. Retinoic acid-induced CCR9 expression requires transient TCR stimulation and cooperativity between NFATc2 and the retinoic acid receptor/retinoid X receptor complex. J. Immunol. 186, 733–744 (2011).
CAS PubMed Article Google Scholar
Cassani, B. et al. Gut-tropic T cells that express integrin α4β7 and CCR9 are required for induction of oral immune tolerance in mice. Gastroenterology 141, 2109–2118 (2011).
CAS PubMed Article Google Scholar
Svensson, M. et al. CCL25 mediates the localization of recently activated CD8αβ+ lymphocytes to the small-intestinal mucosa. J. Clin. Investig. 110, 1113–1121 (2002).
CAS PubMed PubMed Central Article Google Scholar
Xu, Y. et al. In Vivo Generation of Gut-Homing Regulatory T Cells for the Suppression of Colitis. J. Immunol. 202, 3447–3457 (2019).
CAS PubMed Article Google Scholar
Guy-Grand, D. et al. Two gut intraepithelial CD8+ lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation. J. Exp. Med. 173, 471–481 (1991).
CAS PubMed Article Google Scholar
Cheroutre, H., Lambolez, F. & Mucida, D. The light and dark sides of intestinal intraepithelial lymphocytes. Nat. Rev. Immunol. 11, 445–456 (2011).
CAS PubMed PubMed Central Article Google Scholar
Olivares-Villagomez, D. & Kaer, Van L. Intestinal Intraepithelial Lymphocytes: Sentinels of the Mucosal Barrier. Trends Immunol. 39, 264–275 (2018).
CAS PubMed Article Google Scholar
Van Kaer, L. & Olivares-Villagomez, D. Development, Homeostasis, and Functions of Intestinal Intraepithelial Lymphocytes. J. Immunol. 200, 2235–2244 (2018).
PubMed Article CAS Google Scholar
Zhou, C., Qiu, Y. & Yang, H. CD4CD8αα IELs: They Have Something to Say. Front. Immunol. 10, 2269 (2019).
CAS PubMed PubMed Central Article Google Scholar
Mucida, D. et al. Transcriptional reprogramming of mature CD4(+) helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes. Nat. Immunol. 14, 281–289 (2013).
CAS PubMed PubMed Central Article Google Scholar
Xing, Y., Wang, X., Jameson, S. C. & Hogquist, K. A. Late stages of T cell maturation in the thymus involve NF-κB and tonic type I interferon signaling. Nat. Immunol. 17, 565–573 (2016).
CAS PubMed PubMed Central Article Google Scholar
Singer, A., Adoro, S. & Park, J. H. Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice. Nat. Rev. Immunol. 8, 788–801 (2008).
CAS PubMed PubMed Central Article Google Scholar
Egawa, T. & Littman, D. R. ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage. Nat. Immunol. 9, 1131–1139 (2008).
CAS PubMed PubMed Central Article Google Scholar
Keller, H. R. et al. The molecular basis and cellular effects of distinct CD103 expression on CD4 and CD8 T cells. Cell Mol. Life Sci. 78, 5789–5805 (2021).
CAS PubMed Article Google Scholar
Luckey, M. A. et al. The transcription factor ThPOK suppresses Runx3 and imposes CD4(+) lineage fate by inducing the SOCS suppressors of cytokine signaling. Nat. Immunol. 15, 638–645 (2014).
CAS PubMed PubMed Central Article Google Scholar
He, X., Park, K. & Kappes, D. J. The role of ThPOK in control of CD4/CD8 lineage commitment. Annu. Rev. Immunol. 28, 295–320 (2010).
CAS PubMed Article Google Scholar
Muroi, S. et al. Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate. Nat. Immunol. 9, 1113–1121 (2008).
CAS PubMed Article Google Scholar
Engel, I. et al. Co-receptor choice by Vα14i NKT cells is driven by Th-POK expression rather than avoidance of CD8-mediated negative selection. J. Exp. Med. 207, 1015–1029 (2010).
CAS PubMed PubMed Central Article Google Scholar
Wang, L. et al. The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells. Eur. J. Immunol. 40, 2385–2390 (2010).
CAS PubMed PubMed Central Article Google Scholar
Sun, G. et al. The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection. Nat. Immunol. 6, 373–381 (2005).
CAS PubMed Article Google Scholar
Wurbel, M.-A. et al. The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9. Eur. J. Immunol. 30, 262–271 (2000).
CAS PubMed Article Google Scholar
Houston, S. A. et al. The lymph nodes draining the small intestine and colon are anatomically separate and immunologically distinct. Mucosal Immunol. 9, 468–478 (2016).
CAS PubMed Article Google Scholar
Pabst, O. et al. Chemokine receptor CCR9 contributes to the localization of plasma cells to the small intestine. J. Exp. Med. 199, 411–416 (2004).
CAS PubMed PubMed Central Article Google Scholar
Imhof, B. A., Dunon, D., Courtois, D., Luhtala, M. & Vainio, O. Intestinal CD8αα and CD8α β intraepithelial lymphocytes are thymus derived and exhibit subtle differences in TCRβ repertoires. J. Immunol. 165, 6716–6722 (2000).
CAS PubMed Article Google Scholar
Leishman, A. J. et al. Precursors of Functional MHC Class I- or Class II-Restricted CD8αα+ T Cells Are Positively Selected in the Thymus by Agonist Self-Peptides. Immunity 16, 355–364 (2002).
CAS PubMed Article Google Scholar
Reis, B. S., Hoytema van Konijnenburg, D. P., Grivennikov, S. I. & Mucida, D. Transcription factor T-bet regulates intraepithelial lymphocyte functional maturation. Immunity 41, 244–256 (2014).
CAS PubMed PubMed Central Article Google Scholar
Intlekofer, A. M. et al. Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Nat. Immunol. 6, 1236–1244 (2005).
留言 (0)