Gouba, N. & Drancourt, M. Digestive tract mycobiota: a source of infection. Med. et. maladies infectieuses 45, 9–16 (2015).
Underhill, D. M. & Pearlman, E. Immune interactions with pathogenic and commensal fungi: a two-way street. Immunity 43, 845–858 (2015).
CAS PubMed PubMed Central Article Google Scholar
Wheeler, M. L. et al. Immunological consequences of intestinal fungal dysbiosis. Cell Host Microbe 19, 865–873 (2016).
CAS PubMed PubMed Central Article Google Scholar
Iliev, I. D. & Leonardi, I. Fungal dysbiosis: immunity and interactions at mucosal barriers. Nat. Rev. Immunol. 17, 635–646 (2017).
CAS PubMed PubMed Central Article Google Scholar
Revankar S. G., Sobel J. D. Mucosal Candidiasis. In: Calderone R. A., Clancy C. J. (eds.) Candida and Candidiasis, 2nd edn. ASM Press.
Pappas, P. G., Lionakis, M. S., Arendrup, M. C., Ostrosky-Zeichner, L. & Kullberg, B. J. Invasive candidiasis. Nat. Rev. Dis. Prim. 4, 18026 (2018).
Li, X. V., Leonardi, I. & Iliev, I. D. Gut mycobiota in immunity and inflammatory disease. Immunity 50, 1365–1379 (2019).
CAS PubMed PubMed Central Article Google Scholar
Lionakis, M. S. & Levitz, S. M. Host control of fungal infections: lessons from basic studies and human cohorts. Annu. Rev. Immunol. 36, 157–191 (2018).
CAS PubMed Article Google Scholar
Sparber, F. & LeibundGut-Landmann, S. Interleukin-17 in antifungal immunity. Pathogens 8, 54 (2019).
CAS PubMed Central Article Google Scholar
Doron, I. et al. Mycobiota-induced IgA antibodies regulate fungal commensalism in the gut and are dysregulated in Crohn’s disease. Nat. Microbiol. 6, 1493–1504 (2021).
CAS PubMed PubMed Central Article Google Scholar
Millet, N., Solis, N. V. & Swidergall, M. Mucosal IgA prevents commensal candida albicans dysbiosis in the oral cavity. Front. Immunol. 11, 555363 (2020).
CAS PubMed PubMed Central Article Google Scholar
Ost, K. S. et al. Adaptive immunity induces mutualism between commensal eukaryotes. Nature 596, 114–118 (2021).
CAS PubMed PubMed Central Article Google Scholar
Acosta-Rodriguez, E. V. et al. Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat. Immunol. 8, 639–646 (2007).
CAS PubMed Article Google Scholar
Bacher, P. et al. Human anti-fungal Th17 immunity and pathology rely on cross-reactivity against Candida albicans. Cell 176, 1340–1355 e1315 (2019).
CAS PubMed Article Google Scholar
Becattini, S. et al. T cell immunity. Functional heterogeneity of human memory CD4(+) T cell clones primed by pathogens or vaccines. Science 347, 400–406 (2015).
CAS PubMed Article Google Scholar
Park, C. O. et al. Staged development of long-lived T-cell receptor alphabeta TH17 resident memory T-cell population to Candida albicans after skin infection. J. Allergy Clin. Immunol. 142, 647–662 (2018).
CAS PubMed Article Google Scholar
Conti, H. R. et al. Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis. J. Exp. Med. 206, 299–311 (2009).
CAS PubMed PubMed Central Article Google Scholar
Kirchner, F. R. & LeibundGut-Landmann, S. Tissue-resident memory Th17 cells maintain stable fungal commensalism in the oral mucosa. Mucosal Immunol. 14, 455–467 (2021).
CAS PubMed Article Google Scholar
Gladiator, A., Wangler, N., Trautwein-Weidner, K. & LeibundGut-Landmann, S. Cutting edge: IL-17-secreting innate lymphoid cells are essential for host defense against fungal infection. J. Immunol. 190, 521–525 (2013).
CAS PubMed Article Google Scholar
Schonherr, F. A. et al. The intraspecies diversity of C. albicans triggers qualitatively and temporally distinct host responses that determine the balance between commensalism and pathogenicity. Mucosal Immunol. 10, 1335–1350 (2017).
CAS PubMed Article Google Scholar
Verma, A. H. et al. Oral epithelial cells orchestrate innate type 17 responses to Candida albicans through the virulence factor candidalysin. Sci. Immunol. 2, eaam8834 (2017).
PubMed PubMed Central Article Google Scholar
Kashem, S. W. et al. Nociceptive sensory fibers drive Interleukin-23 production from CD301b+ dermal dendritic cells and drive protective cutaneous immunity. Immunity 43, 515–526 (2015).
CAS PubMed PubMed Central Article Google Scholar
Sparber, F. et al. Langerin+ DCs regulate innate IL-17 production in the oral mucosa during Candida albicans-mediated infection. PLoS Pathog. 14, e1007069 (2018).
PubMed PubMed Central Article CAS Google Scholar
Kashem, S. W. et al. Candida albicans morphology and dendritic cell subsets determine T helper cell differentiation. Immunity 42, 356–366 (2015).
CAS PubMed PubMed Central Article Google Scholar
Igyarto, B. Z. et al. Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responses. Immunity 35, 260–272 (2011).
CAS PubMed Article Google Scholar
Trautwein-Weidner, K. et al. Antigen-specific Th17 cells are primed by distinct and complementary dendritic cell subsets in oropharyngeal candidiasis. PLoS Pathog. 11, e1005164 (2015).
PubMed PubMed Central Article CAS Google Scholar
Korn, T., Bettelli, E., Oukka, M. & Kuchroo, V. K. IL-17 and Th17 cells. Annu. Rev. Immunol. 27, 485–517 (2009).
CAS PubMed Article Google Scholar
Ansaldo, E., Farley, T. K. & Belkaid, Y. Control of immunity by the microbiota. Annu. Rev. Immunol. 39, 449–479 (2021).
CAS PubMed Article Google Scholar
Omenetti, S. et al. The intestine harbors functionally distinct homeostatic tissue-resident and inflammatory Th17 cells. Immunity 51, 77–89.e76 (2019).
CAS PubMed PubMed Central Article Google Scholar
Swarnalekha, N. et al. T resident helper cells promote humoral responses in the lung. Sci. Immunol. 6, eabb6808 (2021).
CAS PubMed PubMed Central Article Google Scholar
Tamoutounour, S. et al. Keratinocyte-intrinsic MHCII expression controls microbiota-induced Th1 cell responses. Proc. Natl. Acad. Sci. USA 116, 23643–23652 (2019).
CAS PubMed PubMed Central Article Google Scholar
Leonardi, I. et al. Mucosal fungi promote gut barrier function and social behavior via Type 17 immunity. Cell 185, 831–846 e814 (2022).
CAS PubMed Article Google Scholar
Markey, L. et al. Pre-colonization with the commensal fungus Candida albicans reduces murine susceptibility to Clostridium difficile infection. Gut Microbes 9, 497–509 (2018).
CAS PubMed PubMed Central Google Scholar
Break, T. J. et al. Aberrant type 1 immunity drives susceptibility to mucosal fungal infections. Science 371, eaay5731 (2021).
CAS PubMed PubMed Central Article Google Scholar
Shao, T. Y. et al. Commensal Candida albicans Positively Calibrates Systemic Th17 Immunological Responses. Cell Host Microbe 25, 404–417.e406 (2019).
CAS PubMed PubMed Central Article Google Scholar
Tso, G. H. W. et al. Experimental evolution of a fungal pathogen into a gut symbiont. Science 362, 589–595 (2018).
CAS PubMed Article Google Scholar
Chen, C. et al. IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses. Nature 542, 43–48 (2017).
CAS PubMed PubMed Central Article Google Scholar
Reed, M. D. et al. IL-17a promotes sociability in mouse models of neurodevelopmental disorders. Nature 577, 249–253 (2020).
CAS PubMed Article Google Scholar
Choi, G. B. et al. The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring. Science 351, 933–939 (2016).
留言 (0)