Available online 1 July 2022, 104576

The pro- and anti-tumor functions of neutrophils are reviewed.

Neutrophils contribute to the remodeling of tumor microenvironment.

The functions of neutrophils are modulated by mesenchymal stromal cells.

Neutrophils are the most predominant cell population in the innate immune system. The role of neutrophils in the initiation, development and metastasis of tumor has been actively studied in recent years. In cancer, neutrophils exert both pro- and anti-cancer effects, and their phenotype and function are affected by the tumor microenvironment (TME). This review aims to summarize the role of neutrophils in tumorigenesis with emphasis on their interaction with mesenchymal stromal cells (MSCs).

Neutrophils

tumor microenvironment

metastasis

mesenchymal stromal cells

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