The NOTCH4-GATA4-IRG1 axis as a novel target in early-onset colorectal cancer

Katharina M. Scheurlen received her medical degree at the University of Heidelberg, Germany. She is a resident in General Surgery at the Heidelberg University hospital, Heidelberg, Germany. As a research fellow at the Price Institute of Surgical Research, she obtained a Ph.D. in Physiology from the University of Louisville, Kentucky. Her research is focusing on immunological mechanisms promoting early-onset colorectal cancer and the link between obesity, inflammation and colorectal cancer among the young.

Julia H. Chariker research is focused on the effective use of visualization for scientific discovery. Visualization is a powerful tool for uncovering meaningful patterns in data. Patterns that are difficult or impossible to find in numerical representations of data, may be immediately apparent using an appropriate visualization technique. However, choosing an effective method of visualization can be challenging for scientists dealing with large scale, multidimensional data sets, such as those produced by next-generation sequencing technologies. Many traditional approaches to visualization become ineffective with large scale data, and newer methods of visualization, designed for visualizing large data sets, have not been well-evaluated in terms of their effectiveness. Dr. Chariker is interested in understanding how these new methods of visualization can be used effectively in scientific analysis.

Ziad Kanaanis a gastroenterologist in Dearborn, Michigan and is affiliated with multiple hospitals in the area, including John D. Dingell Veterans Affairs Medical Center and Ascension Providence Rochester Hospital. He received his medical degree from American University of Beirut Faculty of Medicine and has been in practice between 11-20 years.

Andrew Littlefield earned his undergraduate degree in Biochemistry at Hanover College in Hanover, Indiana. He has been a summer research associate at the Price Institute of Surgical Research with the Digestive Surgery Research Laboratory for three years and is studying molecular connections between obesity and early-onset colorectal cancer. He is enrolled at the University of Louisville School of Medicine.

Joan George is a senior pursuing her B.S. in Behavioral Neuroscience at Centre College in Danville, Kentucky. She has worked in the Price Institute of Surgical Research as a research assistant. She is currently in the Cancer Education Program at the University of Louisville. Joan plans to attend medical school.

Caden Seraphine is a junior pursuing his B.S. in Biology at Xavier University in Cincinnati, Ohio. He is working as a research assistant at the Price Institute of Surgical Research. He plans to attend medical school.

Andre Rochet subsequently received his medical degree after graduating with honors from the University of Louisville School of Medicine. He was awarded the Distinction in Research for his involvement in basic science research including participation in the R25 Cancer Education Research program as a Summer Research Scholar. He will complete internal medicine residency training at Duke University Medical Center.

Eric Rouchka's laboratory is primarily interested in algorithmic development and design for use with high throughput genomic and transcriptomic data. The laboratory has ongoing research in the areas of understanding gene regulation from both a transcriptional and translational point of view as well as in the area of systems biology for understanding cross-tissue signalling through an ongoing collaboration with the Petruska lab. Dr. Rouchka's team also uses publicly available next-generation sequence data for studying genomic variation.

Susan Galandiuk received a medical degree from Julius Maximilians Universitaet, Wuerzburg, Germany. She completed a general surgery residency at Cleveland Clinic, Cleveland, Ohio; followed by a research fellowship at Price Institute of Surgical Research, Louisville, Kentucky; and a colon and rectal surgery fellowship at Mayo Clinic, Rochester, Minnesota. She is Professor of Surgery at the University of Louisville School of Medicine, Louisville, Kentucky; and Director of the Division of Colon and Rectal Surgery; as well as Director of the Price Institute of Surgical Research. She is the current Editor-in-Chief of Diseases of the Colon & Rectum. Dr. Galandiuk’s primary clinical interests are in inflammatory bowel disease and advanced and recurrent rectal cancer. Her basic research focuses upon molecular mechanisms of carcinogenesis in inflammatory bowel disease.

© 2022 Published by Elsevier Ltd.

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