Highlighting the Undetectable — Fluorescence Molecular Imaging in Gastrointestinal Endoscopy

Ferlay J, Colombet M, Soerjomataram I, Parkin DM, Piñeros M, Znaor A et al (2021) Cancer statistics for the year 2020: an overview. Int J Cancer. https://doi.org/10.1002/ijc.33588

Săftoiu A, Hassan C, Areia M, Bhutani MS, Bisschops R, Bories E et al (2020) Role of gastrointestinal endoscopy in the screening of digestive tract cancers in Europe: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement. Endoscopy 52(4):293–304

PubMed  Article  Google Scholar 

Braden B, Jones-Morris E (2018) How to get the most out of costly Barrett’s oesophagus surveillance. Dig Liver Dis 50(9):871–877

PubMed  Article  Google Scholar 

Visrodia K, Singh S, Krishnamoorthi R, Ahlquist DA, Wang KK, Iyer PG et al (2016) Magnitude of missed esophageal adenocarcinoma after Barrett’s esophagus diagnosis: a systematic review and meta-analysis. Gastroenterology 150(3):599–607.e7; quiz e14–5

van Rijn JC, Reitsma JB, Stoker J, Bossuyt PM, van Deventer SJ, Dekker E (2006) Polyp miss rate determined by tandem colonoscopy: a systematic review. Am J Gastroenterol 101(2):343–350

PubMed  Article  Google Scholar 

Leufkens AM, van Oijen MG, Vleggaar FP, Siersema PD (2012) Factors influencing the miss rate of polyps in a back-to-back colonoscopy study. Endoscopy 44(5):470–475

CAS  PubMed  Article  Google Scholar 

Stoffel EM, Turgeon DK, Stockwell DH, Zhao L, Normolle DP, Tuck MK et al (2008) Missed adenomas during colonoscopic surveillance in individuals with Lynch syndrome (hereditary nonpolyposis colorectal cancer). Cancer Prev Res (Phila) 1(6):470–475

Article  Google Scholar 

Soetikno R, Subramanian V, Kaltenbach T, Rouse RV, Sanduleanu S, Suzuki N et al (2013) The detection of nonpolypoid (flat and depressed) colorectal neoplasms in patients with inflammatory bowel disease. Gastroenterology 144(7):1349–52, 52.e1–6

Soetikno RM, Kaltenbach T, Rouse RV, Park W, Maheshwari A, Sato T et al (2008) Prevalence of nonpolypoid (flat and depressed) colorectal neoplasms in asymptomatic and symptomatic adults. JAMA 299(9):1027–1035

CAS  PubMed  Article  Google Scholar 

Burggraaf J, Kamerling IM, Gordon PB, Schrier L, de Kam ML, Kales AJ et al (2015) Detection of colorectal polyps in humans using an intravenously administered fluorescent peptide targeted against c-Met. Nat Med 21(8):955–961

CAS  PubMed  Article  Google Scholar 

Joshi BP, Dai Z, Gao Z, Lee JH, Ghimire N, Chen J et al (2017) Detection of sessile serrated adenomas in the proximal colon using wide-field fluorescence endoscopy. Gastroenterology 152(5):1002–13.e9

PubMed  Article  Google Scholar 

Hartmans E, Tjalma JJJ, Linssen MD, Allende PBG, Koller M, Jorritsma-Smit A et al (2018) Potential red-flag identification of colorectal adenomas with wide-field fluorescence molecular endoscopy. Theranostics 8(6):1458–1467

CAS  PubMed  PubMed Central  Article  Google Scholar 

Nagengast WB, Hartmans E, Garcia-Allende PB, Peters FTM, Linssen MD, Koch M et al (2019) Near-infrared fluorescence molecular endoscopy detects dysplastic oesophageal lesions using topical and systemic tracer of vascular endothelial growth factor A. Gut 68(1):7–10

CAS  PubMed  Article  Google Scholar 

Maeda H (2012) Macromolecular therapeutics in cancer treatment: the EPR effect and beyond. J Control Release 164(2):138–144

CAS  PubMed  Article  Google Scholar 

Tummers QR, Hoogstins CE, Peters AA, de Kroon CD, Trimbos JB, van de Velde CJ et al (2015) The value of intraoperative near-infrared fluorescence imaging based on enhanced permeability and retention of Indocyanine Green: feasibility and false-positives in ovarian cancer. PLoS ONE 10(6):e0129766

PubMed  PubMed Central  Article  CAS  Google Scholar 

Regula J, MacRobert AJ, Gorchein A, Buonaccorsi GA, Thorpe SM, Spencer GM et al (1995) Photosensitisation and photodynamic therapy of oesophageal, duodenal, and colorectal tumours using 5 aminolaevulinic acid induced protoporphyrin IX—a pilot study. Gut 36(1):67–75

CAS  PubMed  PubMed Central  Article  Google Scholar 

Zhao SG, Chen XF, Wang LG, Yang G, Han DY, Teng L et al (2013) Increased expression of ABCB6 enhances protoporphyrin IX accumulation and photodynamic effect in human glioma. Ann Surg Oncol 20(13):4379–4388

PubMed  Article  Google Scholar 

Utsuki S, Oka H, Sato S, Shimizu S, Suzuki S, Tanizaki Y et al (2007) Histological examination of false positive tissue resection using 5-aminolevulinic acid-induced fluorescence guidance. Neurol Med Chir (Tokyo) 47(5):210–3; discussion 3–4

Chohan MO, Berger MS (2019) 5-Aminolevulinic acid fluorescence guided surgery for recurrent high-grade gliomas. J Neurooncol 141(3):517–522

CAS  PubMed  Article  Google Scholar 

Vleugels JLA, Rutter MD, Ragunath K, Rees CJ, Ponsioen CY, Lahiff C et al (2018) Chromoendoscopy versus autofluorescence imaging for neoplasia detection in patients with longstanding ulcerative colitis (FIND-UC): an international, multicentre, randomised controlled trial. Lancet Gastroenterol Hepatol 3(5):305–316

PubMed  Article  Google Scholar 

Zhao ZY, Guan YG, Li BR, Shan YQ, Yan FH, Gao YJ et al (2015) Detection and miss rates of autofluorescence imaging of adenomatous and polypoid lesions during colonoscopy: a systematic review and meta-analysis. Endosc Int Open 3(3):E226–E235

PubMed  PubMed Central  Article  Google Scholar 

Takeuchi Y, Sawaya M, Oka S, Tamai N, Kawamura T, Uraoka T et al (2019) Efficacy of autofluorescence imaging for flat neoplasm detection: a multicenter randomized controlled trial (A-FLAT trial). Gastrointest Endosc 89(3):460–469

PubMed  Article  Google Scholar 

Tjalma JJ, Garcia-Allende PB, Hartmans E, Terwisscha van Scheltinga AG, Boersma-vanEk W, Glatz J et al (2016) Molecular fluorescence endoscopy targeting vascular endothelial growth factor A for improved colorectal polyp detection. J Nucl Med 57(3):480–5

CAS  PubMed  Article  Google Scholar 

Terwisscha van Scheltinga AG, van Dam GM, Nagengast WB, Ntziachristos V, Hollema H, Herek JL et al (2011) Intraoperative near-infrared fluorescence tumor imaging with vascular endothelial growth factor and human epidermal growth factor receptor 2 targeting antibodies. J Nucl Med 52(11):1778–85

CAS  PubMed  Article  Google Scholar 

Linders D, Deken M, van der Valk M, Tummers W, Bhairosingh S, Schaap D et al (2021) CEA, EpCAM, αvβ6 and uPAR expression in rectal cancer patients with a pathological complete response after neoadjuvant therapy. Diagnostics (Basel) 11(3):516

CAS  Article  Google Scholar 

Boogerd LSF, Hoogstins CES, Schaap DP, Kusters M, Handgraaf HJM, van der Valk MJM et al (2018) Safety and effectiveness of SGM-101, a fluorescent antibody targeting carcinoembryonic antigen, for intraoperative detection of colorectal cancer: a dose-escalation pilot study. Lancet Gastroenterol Hepatol 3(3):181–191

PubMed  Article  Google Scholar 

Wu AM, Senter PD (2005) Arming antibodies: prospects and challenges for immunoconjugates. Nat Biotechnol 23(9):1137–1146

CAS  PubMed  Article  Google Scholar 

Hoetker MS, Goetz M (2013) Molecular imaging in endoscopy. United European Gastroenterol J 1(2):84–92

PubMed  PubMed Central  Article  Google Scholar 

Tjalma JJJ, Koller M, Linssen MD, Hartmans E, de Jongh S, Jorritsma-Smit A et al (2020) Quantitative fluorescence endoscopy: an innovative endoscopy approach to evaluate neoadjuvant treatment response in locally advanced rectal cancer. Gut 69(3):406–410

CAS  PubMed  Article  Google Scholar 

Nagengast WB (2019) A prospective follow-up intervention study: detection of early esophageal cancer by near-infrared fluoresence molecular endoscopy using bevacizumab-800CW (ESCEND). Identifier NCT03877601. https://clinicaltrials.gov/ct2/show/NCT03877601?cond=Oesophagus+Cancer&cntry=NL&draw=3

Goetz M, Hoetker MS, Diken M, Galle PR, Kiesslich R (2013) In vivo molecular imaging with cetuximab, an anti-EGFR antibody, for prediction of response in xenograft models of human colorectal cancer. Endoscopy 45(6):469–477

CAS  PubMed  Article  Google Scholar 

de Valk KS, Deken MM, Schaap DP, Meijer RP, Boogerd LS, Hoogstins CE et al (2021) Dose-finding study of a CEA-targeting agent, SGM-101, for intraoperative fluorescence imaging of colorectal cancer. Ann Surg Oncol 28(3):1832–1844

PubMed  Article  Google Scholar 

Atreya R, Neumann H, Neufert C, Waldner MJ, Billmeier U, Zopf Y et al (2014) In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn’s disease. Nat Med 20(3):313–318

CAS  PubMed  PubMed Central  Article  Google Scholar 

Rath T, Bojarski C, Neurath MF, Atreya R (2017) Molecular imaging of mucosal α4β7 integrin expression with the fluorescent anti-adhesion antibody vedolizumab in Crohn’s disease. Gastrointest Endosc 86(2):406–408

PubMed  Article  Google Scholar 

Boogerd LSF, Boonstra MC, Prevoo HAJM, Handgraaf HJM, Kuppen PJK, van de Velde CJH et al (2019) Fluorescence-guided tumor detection with a novel anti-EpCAM targeted antibody fragment: preclinical validation. Surg Oncol 28:1–8

PubMed  Article  Google Scholar 

Vahrmeijer AL (2018) Study for intra-operative imaging of gastrointestinal cancer using VB5–845D-800CW. Identifier NTR7570. https://www.trialregister.nl/trial/7363

Bernhard W, El-Sayed A, Barreto K, Gonzalez C, Fonge H, Geyer CR (2019) Near infrared imaging of epidermal growth factor receptor positive xenografts in mice with domain I/II specific antibody fragments. Theranostics 9(4):974–985

CAS  PubMed  PubMed Central  Article  Google Scholar 

de Valk KS, Deken MM, Handgraaf HJM, Bhairosingh SS, Bijlstra OD, van Esdonk MJ et al (2020) First-in-human assessment of cRGD-ZW800-1, a zwitterionic, integrin-targeted, near-infrared fluorescent peptide in colon carcinoma. Clin Cancer Res 26(15):3990–3998

PubMed  Article  Google Scholar 

de Jongh SJ, Voskuil FJ, Schmidt I, Karrenbeld A, Kats-Ugurlu G, Meersma GJ et al (2020) C-Met targeted fluorescence molecular endoscopy in Barrett’s esophagus patients and identification of outcome parameters for phase-I studies. Theranostics 10(12):5357–5367

PubMed  PubMed Central  Article  CAS  Google Scholar 

Chen J, Jiang Y, Chang TS, Joshi B, Zhou J, Rubenstein JH et al (2021) Multiplexed endoscopic imaging of Barrett’s neoplasia using targeted fluorescent heptapeptides in a phase 1 proof-of-concept study. Gut 70(6):1010–1013

CAS  PubMed  Article  Google Scholar 

Yim JJ, Harmsen S, Flisikowski K, Flisikowska T, Namkoong H, Garland M et al (2021) A protease-activated, near-infrared fluorescent probe for early endoscopic detection of premalignant gastrointestinal lesions. Proc Natl Acad Sci U S A 118(1):e2008072118

CAS  PubMed  Article  Google Scholar 

van Dam GM, Themelis G, Crane LM, Harlaar NJ, Pleijhuis RG, Kelder W et al (2011) Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results. Nat Med 17(10):1315–1319

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