∗Division of Trauma and Critical Care, Department of Surgery, Ohio State University, Columbus, Ohio

†Indiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana

‡Division of Pulmonary, Critical Care and Sleep, Department of Medicine, Ohio State University, Columbus, Ohio

§Indian Institute of Technology Ropar, Punjab, India

Address reprint requests to Jon R. Wisler, Ohio State University Wexner Medical Center Department of Surgery, Columbus, Ohio. E-mail: [email protected]

Received 11 January, 2022

Revised 26 January, 2022

Accepted 10 March, 2022

Jon R. Wisler and Kanhaiya Singh contributed equally to this work.

Ethics statement: The material in this submission is not under consideration and has not been published elsewhere. The authors have all approved this submission. Sources of support and conflicts of interested are listed.

Sources of support: GM137078 NIH KO8 (JRW), NIH R01HL137224 (JWC).

The authors have declared no conflict of interest exists.

Author contributions: JW and KS designed the overall study, conducted experiments, acquired data, analyzed data and wrote the manuscript. JW and KS worked collaboratively on all aspects of the project and are listed as co-first authors. JW is listed first because he contributed the majority of the writing, and all financial study support. AM, RH, MK, EH, DM, AA and MK designed and conducted experiments, acquired and analyzed data. JC and CS designed the overall study, analyzed data, and edited the manuscript.

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