Scarfo L, Ferreri AJ, Ghia P. Chronic lymphocytic leukaemia. Crit Rev Oncol Hematol. 2016;104:169–82.

PubMed  Article  Google Scholar 

DeBerardinis RJ, Thompson CB. Cellular metabolism and disease: what do metabolic outliers teach us? Cell. 2012;148(6):1132–44.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Zhang Y, Zhou X, Li Y, Xu Y, Lu K, Li P, et al. Inhibition of maternal embryonic leucine zipper kinase with OTSSP167 displays potent anti-leukemic effects in chronic lymphocytic leukemia. Oncogene. 2018;37(41):5520–33.

CAS  PubMed  Article  Google Scholar 

Lu K, Wang X. Therapeutic advancement of chronic lymphocytic leukemia. J Hematol Oncol. 2012;5:55.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Klener P, Sovilj D, Renesova N, Andera L. BH3 mimetics in hematologic malignancies. Int J Mol Sci. 2021;22(18):10157.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Billard C. Design of novel BH3 mimetics for the treatment of chronic lymphocytic leukemia. Leukemia. 2012;26(9):2032–8.

CAS  PubMed  Article  Google Scholar 

Tian Z, Liu M, Fang X, Zhou X, Li P, Li Y, et al. Distinct age-related clinical features and risk assessment in Chinese with chronic lymphocytic leukemia. Front Oncol. 2022. https://doi.org/10.3389/fonc.2022.885150.

Article  PubMed  PubMed Central  Google Scholar 

Zhang J, Lu X, Li J, Miao Y. Combining BTK inhibitors with BCL2 inhibitors for treating chronic lymphocytic leukemia and mantle cell lymphoma. Biomark Res. 2022;10(1):17.

PubMed  PubMed Central  Article  Google Scholar 

Wang S, Fu JL, Hao HF, Jiao YN, Li PP, Han SY. Metabolic reprogramming by traditional Chinese medicine and its role in effective cancer therapy. Pharmacol Res. 2021;170:105728.

CAS  PubMed  Article  Google Scholar 

Li Z, Geng M, Ye X, Ji Y, Li Y, Zhang X, et al. IRF7 inhibits the Warburg effect via transcriptional suppression of PKM2 in osteosarcoma. Int J Biol Sci. 2022;18(1):30–42.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Sneeggen M, Guadagno NA, Progida C. Intracellular transport in cancer metabolic reprogramming. Front Cell Dev Biol. 2020;8:597608.

PubMed  PubMed Central  Article  Google Scholar 

Sun L, Suo C, Li ST, Zhang H, Gao P. Metabolic reprogramming for cancer cells and their microenvironment: beyond the Warburg effect. Biochim Biophys Acta Rev Cancer. 2018;1870(1):51–66.

CAS  PubMed  Article  Google Scholar 

La Vecchia S, Sebastián C. Metabolic pathways regulating colorectal cancer initiation and progression. Semin Cell Dev Biol. 2020;98:63–70.

PubMed  Article  CAS  Google Scholar 

Luo X, Cheng C, Tan Z, Li N, Tang M, Yang L, et al. Emerging roles of lipid metabolism in cancer metastasis. Mol Cancer. 2017;16(1):76.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Pavlova NN, Thompson CB. The emerging hallmarks of cancer metabolism. Cell Metab. 2016;23(1):27–47.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Xia L, Oyang L, Lin J, Tan S, Han Y, Wu N, et al. The cancer metabolic reprogramming and immune response. Mol Cancer. 2021;20(1):28.

PubMed  PubMed Central  Article  Google Scholar 

Landau DA, Tausch E, Taylor-Weiner AN, Stewart C, Reiter JG, Bahlo J, et al. Mutations driving CLL and their evolution in progression and relapse. Nature. 2015;526(7574):525–30.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Faubert B, Solmonson A, DeBerardinis RJ. Metabolic reprogramming and cancer progression, vol. 368. New York: Science; 2020.

Google Scholar 

Ganapathy-Kanniappan S, Geschwind JF. Tumor glycolysis as a target for cancer therapy: progress and prospects. Mol Cancer. 2013;12:152.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Bonora M, Patergnani S, Rimessi A, De Marchi E, Suski JM, Bononi A, et al. ATP synthesis and storage. Purinergic Signal. 2012;8(3):343–57.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Han X, Raun SH, Carlsson M, Sjoberg KA, Henriquez-Olguin C, Ali M, et al. Cancer causes metabolic perturbations associated with reduced insulin-stimulated glucose uptake in peripheral tissues and impaired muscle microvascular perfusion. Metabolism. 2020;105:154169.

CAS  PubMed  Article  Google Scholar 

Li X, Yu C, Luo Y, Lin J, Wang F, Sun X, et al. Aldolase A enhances intrahepatic cholangiocarcinoma proliferation and invasion through promoting glycolysis. Int J Biol Sci. 2021;17(7):1782–94.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Kalyanaraman B. Teaching the basics of cancer metabolism: developing antitumor strategies by exploiting the differences between normal and cancer cell metabolism. Redox Biol. 2017;12:833–42.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Pascale RM, Calvisi DF, Simile MM, Feo CF, Feo F. The Warburg effect 97 years after its discovery. Cancers. 2020;12(10):2819.

CAS  PubMed Central  Article  Google Scholar 

Lu J, Bottcher M, Walther T, Mougiakakos D, Zenz T, Huber W. Energy metabolism is co-determined by genetic variants in chronic lymphocytic leukemia and influences drug sensitivity. Haematologica. 2019;104(9):1830–40.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Jitschin R, Braun M, Qorraj M, Saul D, Le Blanc K, Zenz T, et al. Stromal cell-mediated glycolytic switch in CLL cells involves Notch-c-Myc signaling. Blood. 2015;125(22):3432–6.

CAS  PubMed  Article  Google Scholar 

Christiansen JR, Kanellopoulos A, Lund MB, Massey R, Dalen H, Kiserud CE, et al. Impaired exercise capacity and left ventricular function in long-term adult survivors of childhood acute lymphoblastic leukemia. Pediatr Blood Cancer. 2015;62(8):1437–43.

PubMed  Article  Google Scholar 

Lunt SY, Vander Heiden MG. Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu Rev Cell Dev Biol. 2011;27:441–64.

CAS  PubMed  Article  Google Scholar 

Macheda ML, Rogers S, Best JD. Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer. J Cell Physiol. 2005;202(3):654–62.

CAS  PubMed  Article  Google Scholar 

Barron CC, Bilan PJ, Tsakiridis T, Tsiani E. Facilitative glucose transporters: implications for cancer detection, prognosis and treatment. Metabolism. 2016;65(2):124–39.

CAS  PubMed  Article  Google Scholar 

Schwartzenberg-Bar-Yoseph F, Armoni M, Karnieli E. The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression. Cancer Res. 2004;64(7):2627–33.

CAS  PubMed  Article  Google Scholar 

Liu J, Zhang C, Lin M, Zhu W, Liang Y, Hong X, et al. Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma. Oncotarget. 2014;5(9):2635–47.

PubMed  PubMed Central  Article  Google Scholar 

Gomes AS, Ramos H, Soares J, Saraiva L. p53 and glucose metabolism: an orchestra to be directed in cancer therapy. Pharmacol Res. 2018;131:75–86.

CAS  PubMed  Article  Google Scholar 

Hong M, Xia Y, Zhu Y, Zhao HH, Zhu H, Xie Y, et al. TP53-induced glycolysis and apoptosis regulator protects from spontaneous apoptosis and predicts poor prognosis in chronic lymphocytic leukemia. Leuk Res. 2016;50:72–7.

CAS  PubMed  Article  Google Scholar 

Guo W, Wang X, Li Y, Bai O. Function and regulation of lipid signaling in lymphomagenesis: a novel target in cancer research and therapy. Crit Rev Oncol Hematol. 2020;154:103071.

PubMed  Article  Google Scholar 

Liu Y, Zhou X, Wang X. Targeting the tumor microenvironment in B-cell lymphoma: challenges and opportunities. J Hematol Oncol. 2021;14(1):125.

PubMed  PubMed Central  Article  Google Scholar 

Bilban M, Heintel D, Scharl T, Woelfel T, Auer MM, Porpaczy E, et al. Deregulated expression of fat and muscle genes in B-cell chronic lymphocytic leukemia with high lipoprotein lipase expression. Leukemia. 2006;20(6):1080–8.

CAS  PubMed  Article  Google Scholar 

Heintel D, Kienle D, Shehata M, Krober A, Kroemer E, Schwarzinger I, et al. High expression of lipoprotein lipase in poor risk B-cell chronic lymphocytic leukemia. Leukemia. 2005;19(7):1216–23.

CAS  PubMed  Article