Mechanisms behind context-dependent role of glucocorticoids in breast cancer progression

Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 71, 209–249. https://doi.org/10.3322/caac.21660

Article  Google Scholar 

Tsang, J. Y. S., & Tse, G. M. (2020). Molecular classification of breast cancer. Advances in Anatomic Pathology, 27, 27–35. https://doi.org/10.1097/PAP.0000000000000232

CAS  Article  PubMed  Google Scholar 

Lamb, C. A., Vanzulli, S. I., & Lanari, C. (2019). Hormone receptors in breast cancer: More than estrogen receptors. Medicina (B Aires), 79, 540–545.

CAS  Google Scholar 

Nelson, D. R., Brown, J., Morikawa, A., & Method, M. (2022). Breast cancer-specific mortality in early breast cancer as defined by high-risk clinical and pathologic characteristics. PLoS One, 17, e0264637. https://doi.org/10.1371/journal.pone.0264637

CAS  Article  PubMed  PubMed Central  Google Scholar 

Cardoso, F., Senkus, E., Costa, A., Papadopoulos, E., Aapro, M., André, F., Harbeck, N., Aguilar Lopez, B., Barrios, C. H., Bergh, J., et al. (2018). 4th ESO–ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 4). Annals of Oncology, 29, 1634–1657. https://doi.org/10.1093/annonc/mdy192

CAS  Article  PubMed  Google Scholar 

Noureddine, L. M., Trédan, O., Hussein, N., Badran, B., Le Romancer, M., & Poulard, C. (2021). Glucocorticoid receptor: A multifaceted actor in breast cancer. International Journal of Molecular Sciences, 22, 4446. https://doi.org/10.3390/ijms22094446

CAS  Article  PubMed  PubMed Central  Google Scholar 

Obradović, M. M. S., Hamelin, B., Manevski, N., Couto, J. P., Sethi, A., Coissieux, M.-M., Münst, S., Okamoto, R., Kohler, H., Schmidt, A., et al. (2019). Glucocorticoids promote breast cancer metastasis. Nature, 567, 540–544. https://doi.org/10.1038/s41586-019-1019-4

CAS  Article  PubMed  Google Scholar 

Zhidkova, E. M., Lylova, E. S., Savinkova, A. V., Mertsalov, S. A., Kirsanov, K. I., Belitsky, G. A., Yakubovskaya, M. G., & Lesovaya, E. A. (2020). A brief overview of the paradoxical role of glucocorticoids in breast cancer. Breast Cancer (Auckl), 14, 1178223420974667. https://doi.org/10.1177/1178223420974667

Article  PubMed Central  Google Scholar 

Mayayo-Peralta, I., Zwart, W., & Prekovic, S. (2021). Duality of glucocorticoid action in cancer: Tumor-suppressor or oncogene? Endocrine-Related Cancer, 28, R157–R171. https://doi.org/10.1530/ERC-20-0489

CAS  Article  PubMed  Google Scholar 

Vandevyver, S., Dejager, L., & Libert, C. (2014). Comprehensive overview of the structure and regulation of the glucocorticoid receptor. Endocrine Reviews, 35, 671–693. https://doi.org/10.1210/er.2014-1010

CAS  Article  PubMed  Google Scholar 

Chrousos, G. P., & Kino, T. (2005). Intracellular glucocorticoid signaling: a formerly simple system turns stochastic. Science STKE, 2005, pe48. https://doi.org/10.1126/stke.3042005pe48

Article  Google Scholar 

Zhou, J., & Cidlowski, J. A. (2005). The human glucocorticoid receptor: One gene, multiple proteins and diverse responses. Steroids, 70, 407–417. https://doi.org/10.1016/j.steroids.2005.02.006

CAS  Article  PubMed  Google Scholar 

Duma, D., Jewell, C. M., & Cidlowski, J. A. (2006). Multiple glucocorticoid receptor isoforms and mechanisms of post-translational modification. Journal of Steroid Biochemistry and Molecular Biology, 102, 11–21. https://doi.org/10.1016/j.jsbmb.2006.09.009

CAS  Article  PubMed  Google Scholar 

Luisi, B. F., Xu, W. X., Otwinowski, Z., Freedman, L. P., Yamamoto, K. R., & Sigler, P. B. (1991). Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA. Nature, 352, 497–505. https://doi.org/10.1038/352497a0

CAS  Article  PubMed  Google Scholar 

Watson, L. C., Kuchenbecker, K. M., Schiller, B. J., Gross, J. D., Pufall, M. A., & Yamamoto, K. R. (2013). The glucocorticoid receptor dimer interface allosterically transmits sequence-specific DNA signals. Nature Structural & Molecular Biology, 20, 876–883. https://doi.org/10.1038/nsmb.2595

CAS  Article  Google Scholar 

Nader, N., Chrousos, G. P., & Kino, T. (2009). Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: Potential physiological implications. The FASEB Journal, 23, 1572–1583. https://doi.org/10.1096/fj.08-117697

CAS  Article  PubMed  PubMed Central  Google Scholar 

Bledsoe, R. K., Montana, V. G., Stanley, T. B., Delves, C. J., Apolito, C. J., McKee, D. D., Consler, T. G., Parks, D. J., Stewart, E. L., Willson, T. M., et al. (2002). Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition. Cell, 110, 93–105. https://doi.org/10.1016/S0092-8674(02)00817-6

CAS  Article  PubMed  Google Scholar 

Scheschowitsch, K., Leite, J.A., Assreuy, J. (2017). New insights in glucocorticoid receptor signaling—more than just a ligand-binding receptor. Frontiers in Endocrinology, 8. doi: https://doi.org/10.3389/fendo.2017.00016

Morishima, Y., Murphy, P. J., Li, D. P., Sanchez, E. R., & Pratt, W. B. (2000). Stepwise assembly of a glucocorticoid receptor.hsp90 heterocomplex resolves two sequential ATP-dependent events involving first hsp70 and then hsp90 in opening of the steroid binding pocket. Journal of Biological Chemistry, 275, 18054–18060. https://doi.org/10.1074/jbc.M000434200

CAS  Article  PubMed  Google Scholar 

Ramos-Ramírez, P., & Tliba, O. (2021). Glucocorticoid receptor β (GRβ): Beyond its dominant-negative function. International Journal of Molecular Sciences, 22, 3649. https://doi.org/10.3390/ijms22073649

CAS  Article  PubMed  PubMed Central  Google Scholar 

Groeneweg, F. L., van Royen, M. E., Fenz, S., Keizer, V. I. P., Geverts, B., Prins, J., de Kloet, E. R., Houtsmuller, A. B., Schmidt, T. S., & Schaaf, M. J. M. (2014). Quantitation of glucocorticoid receptor DNA-binding dynamics by single-molecule microscopy and FRAP. PLoS One, 9, e90532. https://doi.org/10.1371/journal.pone.0090532

CAS  Article  PubMed  PubMed Central  Google Scholar 

Ratman, D., Vanden Berghe, W., Dejager, L., Libert, C., Tavernier, J., Beck, I. M., & De Bosscher, K. (2013). How glucocorticoid receptors modulate the activity of other transcription factors: A scope beyond tethering. Molecular and Cellular Endocrinology, 380, 41–54. https://doi.org/10.1016/j.mce.2012.12.014

CAS  Article  PubMed  Google Scholar 

Newton, R. (2000). Molecular mechanisms of glucocorticoid action: What is important? Thorax, 55, 603–613. https://doi.org/10.1136/thorax.55.7.603

CAS  Article  PubMed  PubMed Central  Google Scholar 

Revollo, J. R., & Cidlowski, J. A. (2009). Mechanisms generating diversity in glucocorticoid receptor signaling. Annals of the New York Academy of Sciences, 1179, 167–178. https://doi.org/10.1111/j.1749-6632.2009.04986.x

CAS  Article  PubMed  Google Scholar 

Lim, H.-W., Uhlenhaut, N. H., Rauch, A., Weiner, J., Hübner, S., Hübner, N., Won, K.-J., Lazar, M. A., Tuckermann, J., & Steger, D. J. (2015). Genomic redistribution of GR monomers and dimers mediates transcriptional response to exogenous glucocorticoid in vivo. Genome Research, 25, 836–844. https://doi.org/10.1101/gr.188581.114

CAS  Article  PubMed  PubMed Central  Google Scholar 

Schiller, B. J., Chodankar, R., Watson, L. C., Stallcup, M. R., & Yamamoto, K. R. (2014). Glucocorticoid receptor binds half sites as a monomer and regulates specific target genes. Genome Biology, 15, 418. https://doi.org/10.1186/s13059-014-0418-y

CAS  Article  PubMed  PubMed Central  Google Scholar 

Surjit, M., Ganti, K. P., Mukherji, A., Ye, T., Hua, G., Metzger, D., Li, M., & Chambon, P. (2011). Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor. Cell, 145, 224–241. https://doi.org/10.1016/j.cell.2011.03.027

CAS  Article  PubMed  Google Scholar 

Tiwari, M., Oasa, S., Yamamoto, J., Mikuni, S., & Kinjo, M. (2017). A quantitative study of internal and external interactions of homodimeric glucocorticoid receptor using fluorescence cross-correlation spectroscopy in a live cell. Science and Reports, 7, 4336. https://doi.org/10.1038/s41598-017-04499-7

CAS  Article  Google Scholar 

Petta, I., Dejager, L., Ballegeer, M., Lievens, S., Tavernier, J., De Bosscher, K., & Libert, C. (2016). The interactome of the glucocorticoid receptor and its influence on the actions of glucocorticoids in combatting inflammatory and infectious diseases. Microbiology and Molecular Biology Reviews, 80, 495–522. https://doi.org/10.1128/MMBR.00064-15

CAS  Article  PubMed  PubMed Central  Google Scholar 

Robertson, S., Rohwer, J. M., Hapgood, J. P., & Louw, A. (2013). Impact of glucocorticoid receptor density on ligand-independent dimerization, cooperative ligand-binding and basal priming of transactivation: A cell culture model. PLoS One, 8, e64831. https://doi.org/10.1371/journal.pone.0064831

CAS  Article  PubMed  PubMed Central  Google Scholar 

Ritter, H. D., & Mueller, C. R. (2014). Expression microarray identifies the unliganded glucocorticoid receptor as a regulator of gene expression in mammary epithelial cells. BMC Cancer, 14, 275. https://doi.org/10.1186/1471-2407-14-275

CAS  Article  PubMed  PubMed Central  Google Scholar 

Ritter, H. D., Antonova, L., & Mueller, C. R. (2012). The unliganded glucocorticoid receptor positively regulates the tumor suppressor gene BRCA1 through GABP Beta. Molecular Cancer Research, 10, 558–569. https://doi.org/10.1158/1541-7786.MCR-11-0423-T

CAS  Article  PubMed  Google Scholar 

Verhoog, N. J. D., Du Toit, A., Avenant, C., & Hapgood, J. P. (2011). Glucocorticoid-independent repression of tumor necrosis factor (TNF) α-stimulated interleukin (IL)-6 expression by the glucocorticoid receptor. Journal of Biological Chemistry, 286, 19297–19310. https://doi.org/10.1074/jbc.M110.193672

CAS  Article  PubMed  PubMed Central  Google Scholar 

Hollenberg, S. M., & Evans, R. M. (1988). Multiple and cooperative trans-activation domains of the human glucocorticoid receptor. Cell, 55, 899–906. https://doi.org/10.1016/0092-8674(88)90145-6

CAS  Article  PubMed  Google Scholar 

Ramamoorthy, S., & Cidlowski, J. A. (2013). Exploring the molecular mechanisms of glucocorticoid receptor action from sensitivity to resistance. Endocrine Development, 24

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