Edward J, Carreon LY, Williams MV, Glassman S, Li J. The importance and impact of patients' health literacy on low back pain management: a systematic review of literature. Spine J. 2018;18(2):370-6. https://doi.org/10.1016/j.spinee.2017.09.005

Le Maitre CL, Binch AL, Thorpe AA, Hughes SP. Degeneration of the intervertebral disc with new approaches for treating low back pain. J Neurosurg Sci. 2015;59(1):47-61.

Petit A, Roquelaure Y. Low back pain, intervertebral disc and occupational diseases. Int J Occup Saf Ergon. 2015;21(1):15-9. https://doi.org/10.1080/10803548.2015.1017940

Xu TT, Liao F, Jin HT, Tong PJ, Xiao LW, Wu CL. [Research advance on intervertebral disc degeneration and cell death]. Zhongguo Gu Shang. 2015;28(7):673-8. Chinese.

Maiuri MC, Zalckvar E, Kimchi A, Kroemer G. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol. 2007;8(9):741-52. https://doi.org/10.1038/nrm2239

Yurube T, Ito M, Kakiuchi Y, Kuroda R, Kakutani K. Autophagy and mTOR signaling during intervertebral disc aging and degeneration. JOR Spine. 2020;3(1):e1082. https://doi.org/10.1002/jsp2.1082

Zhang SJ, Yang W, Wang C, He WS, Deng HY, Yan YG, Zhang J, Xiang YX, Wang WJ. Autophagy: A double-edged sword in intervertebral disk degeneration. Clin Chim Acta. 2016;457:27-35. https://doi.org/10.1016/j.cca.2016.03.016

Azad MB, Chen Y, Henson ES, Cizeau J, McMillan-Ward E, Israels SJ, Gibson SB. Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3. Autophagy. 2008;4(2):195-204. https://doi.org/10.4161/auto.5278

Kubasiak LA, Hernandez OM, Bishopric NH, Webster KA. Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3. Proc Natl Acad Sci U S A. 2002;99(20):12825-30. https://doi.org/10.1073/pnas.202474099

Hamacher-Brady A, Brady NR, Logue SE, Sayen MR, Jinno M, Kirshenbaum LA, Gottlieb RA, Gustafsson AB. Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy. Cell Death Differ. 2007;14(1):146-57. https://doi.org/10.1038/sj.cdd.4401936

Sowter HM, Ratcliffe PJ, Watson P, Greenberg AH, Harris AL. HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Cancer Res. 2001;61(18):6669-73.

Zhang T, Xue L, Li L, Tang C, Wan Z, Wang R, Tan J, Tan Y, Han H, Tian R, Billiar TR, Tao WA, Zhang Z. BNIP3 Protein suppresses PINK1 kinase proteolytic cleavage to promote mitophagy. J Biol Chem. 2016;291(41):21616-29. https://doi.org/10.1074/jbc.M116.733410

Choi H, Merceron C, Mangiavini L, Seifert EL, Schipani E, Shapiro IM, Risbud MV. Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling. Autophagy. 2016;12(9):1631-46. https://doi.org/10.1080/15548627.2016.1192753

Vasagiri N, Kutala VK. Structure, function, and epigenetic regulation of BNIP3: a pathophysiological relevance. Mol Biol Rep. 2014;41(11):7705-14. https://doi.org/10.1007/s11033-014-3664-x

Ney PA. Mitochondrial autophagy: Origins, significance, and role of BNIP3 and NIX. Biochim Biophys Acta. 2015;1853(10 Pt B):2775-83. https://doi.org/10.1016/j.bbamcr.2015.02.022

Liu J, Peng N, Lu Y, Wang J. Preliminary research for correlation between BNIP3 expression and disc degeneration. Chin J Spine Spinal Cord. 2012;22(1):65-71. Chinese.

Liu J, Peng N, Wang J. Immunohistochemistry research on BNIP3 expressions of degenerated intervertebral disc in rabbit. J Reg Anat Oper Surg. 2012;21(1):3-5. Chinese.

Zhang F, Zhao X, Shen H, Zhang C. Molecular mechanisms of cell death in intervertebral disc degeneration (Review). Int J Mol Med. 2016 Jun;37(6):1439-48. https://doi.org/10.3892/ijmm.2016.2573

Shen X, Jiang H. Research progress on the relationship between autophagy and intervertebral disc degeneration. Chin J Trad Med Traum Orthop. 2017;25(8):77-82. Chinese.

Peng A, Yin C, Wu T, Huang W, Cheng X. Progress in association between autophagy and intervertebral disc degeneration. Chin J Cell Biol. 2016;38(11):1382-90. Chinese.

Chen D, Zhou K, Xu H. Research progress on the role of autophagy in intervertebral disc degeneration. J Med Res. 2016;45(12):9-12. Chinese.

Ding F, Shao ZW, Xiong LM. Cell death in intervertebral disc degeneration. Apoptosis. 2013;18(7):777-85. https://doi.org/10.1007/s10495-013-0839-1

Chen JW, Ni BB, Li B, Yang YH, Jiang SD, Jiang LS. The responses of autophagy and apoptosis to oxidative stress in nucleus pulposus cells: implications for disc degeneration. Cell Physiol Biochem. 2014;34(4):1175-89. https://doi.org/10.1159/000366330

Mizushima N. Autophagy: process and function. Genes Dev. 2007;21(22):2861-73. https://doi.org/10.1101/gad.1599207

Yorimitsu T, Klionsky DJ. Autophagy: molecular machinery for self-eating. Cell Death Differ. 2005;12 Suppl 2:1542-52. https://doi.org/10.1038/sj.cdd.4401765

Ye W, Xu K, Huang D, Liang A, Peng Y, Zhu W, Li C. Age-related increases of macroautophagy and chaperone-mediated autophagy in rat nucleus pulposus. Connect Tissue Res. 2011;52(6):472-8. https://doi.org/10.3109/03008207.2011.564336

Xu H, Xiong S, Wang H, Zhang M, Yu Y. The evidence and the possible significance of autophagy in degeneration model of human cervical end-plate cartilage. Exp Ther Med. 2014;7(3):537-42. https://doi.org/10.3892/etm.2013.1465

Gruber HE, Hoelscher GL, Ingram JA, Bethea S, Hanley EN Jr. Autophagy in the degenerating human intervertebral disc: in vivo molecular and morphological evidence, and induction of autophagy in cultured annulus cells exposed to proinflammatory cytokines-implications for disc degeneration. Spine (Phila Pa 1976). 2015;40(11):773-82. https://doi.org/10.1097/BRS.0000000000000865

Burton TR, Gibson SB. The role of Bcl-2 family member BNIP3 in cell death and disease: NIPping at the heels of cell death. Cell Death Differ. 2009;16(4):515-23. https://doi.org/10.1038/cdd.2008.185

Zhang J, Ney PA. Role of BNIP3 and NIX in cell death, autophagy, and mitophagy. Cell Death Differ. 2009;16(7):939-46. https://doi.org/10.1038/cdd.2009.16

Liu J, Wang J, Zhou Y. Upregulation of BNIP3 and translocation to mitochondria in nutrition deprivation induced apoptosis in nucleus pulposus cells. Joint Bone Spine. 2012;79(2):186-91. https://doi.org/10.1016/j.jbspin.2011.04.011

Willis S, Day CL, Hinds MG, Huang DCS. The Bcl-2-regulated apoptotic pathway. J Cell Sci. 2003;116(20):4053-6. https://doi.org/10.1242/jcs.00754

Kang R, Zeh HJ, Lotze MT, Tang D. The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ. 2011;18(4):571-80. https://doi.org/10.1038/cdd.2010.191

Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N, Packer M, Schneider MD, Levine B. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell. 2005;122(6):927-39. https://doi.org/10.1016/j.cell.2005.07.002

Decuypere JP, Parys JB, Bultynck G. Regulation of the autophagic bcl-2/beclin 1 interaction. Cells. 2012;1(3):284-312. https://doi.org/10.3390/cells1030284

Sheng R, Qin ZH. The divergent roles of autophagy in ischemia and preconditioning. Acta Pharmacol Sin. 2015;36(4):411-20. https://doi.org/10.1038/aps.2014.151