Ginsenoside-Mc1 reduces cerebral ischemia-reperfusion injury in hyperlipidemia through mitochondrial improvement and attenuation of oxidative/endoplasmic reticulum stress

Kuriakose D, Xiao Z. Pathophysiology and Treatment of Stroke: Present Status and Future Perspectives. Int J Mol Sci. 2020;21(20):7609. https://doi.org/10.3390/ijms21207609

Changjiang S, Feng W, Dandan C, Jianbin G. Therapeutic effects of polysaccharides extracted from Porphyra yezoensis in rats with cerebral ischemia/reperfusion injury. Arch Biol Sci. 2018;70(2):233-9. https://doi.org/10.2298/ABS170621039S

Wu L, Xiong X, Wu X, Ye Y, Jian Z, Zhi Z. Targeting oxidative stress and inflammation to prevent ischemia-reperfusion injury. Front Mol Neurosci. 2020;13:28. https://doi.org/10.3389/fnmol.2020.00028

Menet R, Bernard M, ElAli A. Hyperlipidemia in stroke pathobiology and therapy: Insights and perspectives. Front Physiol. 2018;9:488. https://doi.org/10.3389/fphys.2018.00488

Cao X-L, Du J, Zhang Y, Yan J-T, Hu X-M. Hyperlipidemia exacerbates cerebral injury through oxidative stress, inflammation and neuronal apoptosis in MCAO/reperfusion rats. Exp Brain Res. 2015;233:2753-65. https://doi.org/10.1007/s00221-015-4269-x

Žitňanová I, Šiarnik P, Kollár B, Chomová M, Pazderová P, Andrezálová. Oxidative stress markers and their dynamic changes in patients after acute ischemic stroke. Oxid Med Cell Longev. 2016;2016:9761697. https://doi.org/10.1155/2016/9761697

Bhatti JS, Bhatti GK, Reddy PH. Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria-based therapeutic strategies. Biochim Biophys Acta Mol Basis Dis. 2017;1863(5):1066-77. https://doi.org/10.1016/j.bbadis.2016.11.010

Yuan F, Fu H, Sun K, Wu S, Dong T. Effect of dexmedetomidine on cerebral ischemia-reperfusion rats by activating mitochondrial ATP-sensitive potassium channel. Metab Brain Dis. 2017;32(2):539-46. https://doi.org/10.1007/s11011-016-9945-4

Csonka C, Kupai K, Bencsik P, Görbe A, Pálóczi J, Zvara A, Puskás LG, Csont T, Ferdinandy P. Cholesterol-enriched diet inhibits cardioprotection by ATP-sensitive K+ channel activators cromakalim and diazoxide. Am J Physiol Heart Circ Physiol. 2014;306(3):H405-13. https://doi.org/10.1152/ajpheart.00257.2013

Bajgar R. Seetharaman S, Kowaltowski AJ, Garlid KD, Paucek P. Identification and properties of a novel intracellular (mitochondrial) ATP-sensitive potassium channel in brain. J Biol Chem. 2001;276(36):33369-74. https://doi.org/10.1074/jbc.M103320200

Xin Q, Ji B, Cheng B, Wang C, Liu H, Chen X. Endoplasmic reticulum stress in cerebral ischemia. Neurochem Int. 2014;68:18-27. https://doi.org/10.1016/j.neuint.2014.02.001

Nakka VP, Prakash-Babu P, Vemuganti R. Crosstalk between endoplasmic reticulum stress, oxidative stress, and autophagy: potential therapeutic targets for acute CNS injuries. Mol Neurobiol. 2016;53(1):532-44. https://doi.org/10.1007/s12035-014-9029-6

Basseri S, Austin RC. Endoplasmic reticulum stress and lipid metabolism: mechanisms and therapeutic potential. Biochem Res Int. 2012;2012:841362. https://doi.org/10.1155/2012/841362

Gui Q-f, Xu Z-R, Xu K-Y, Yang Y-M. The efficacy of ginseng-related therapies in type 2 diabetes mellitus: an updated systematic review and meta-analysis. Medicine (Baltimore). 2016;95(6):e2584. https://doi.org/10.1097/MD.0000000000002584

Shen M-H, Zhang C-B, Zhang J-H, Li P-F. Electroacupuncture attenuates cerebral ischemia and reperfusion injury in middle cerebral artery occlusion of rat via modulation of apoptosis, inflammation, oxidative stress, and excitotoxicity. Evid Based Complement Alternat Med. 2016;2016:9438650. https://doi.org/10.1155/2016/9438650

Wang W, Wang W, Chen K. Protective effect and mechanism of ginsenosides on central nerve system of animals. Chin J integr Tradit West Med. 2005;25(1):89-93.

Zhou Y, Li H-Q, Lu L, Fu D-L, Liu A-J, Li J-H. Ginsenoside Rg1 provides neuroprotection against blood brain barrier disruption and neurological injury in a rat model of cerebral ischemia/reperfusion through downregulation of aquaporin 4 expression. Phytomedicine. 2014;21(7):998-1003. https://doi.org/10.1016/j.phymed.2013.12.005

Liu C-Y, Zhou R-X, Sun C-K, Jin Y-H, Yu H-S, Zhang T-Y. Preparation of minor ginsenosides C-Mc, CY, F2, and CK from American ginseng PPD-ginsenoside using special ginsenosidase type-I from Aspergillus niger g. 848. J Ginseng Res. 2015;39(3):221-9. https://doi.org/10.1016/j.jgr.2014.12.003

Shin K-C, Oh D-K. Classification of glycosidases that hydrolyze the specific positions and types of sugar moieties in ginsenosides. Crit Rev Biotechnol. 2016;36(6):1036-49. https://doi.org/10.3109/07388551.2015.1083942

Chen W, Wang J, Luo Y, Wang T, Li X, Li A. Ginsenoside Rb1 and compound K improve insulin signaling and inhibit ER stress-associated NLRP3 inflammasome activation in adipose tissue. J Ginseng Res. 2016;40(4):351-8. https://doi.org/10.1016/j.jgr.2015.11.002

Liu D, Zhang H, Gu W, Liu Y, Zhang M. Neuroprotective effects of ginsenoside Rb1 on high glucose-induced neurotoxicity in primary cultured rat hippocampal neurons. PLoS One. 2013;8(11):e79399. https://doi.org/10.1371/journal.pone.0079399

Roh E, Hwang H-J, Kim J-W, Hong S-h, Kim J-A, Lee Y-B. Ginsenoside Mc1 improves liver steatosis and insulin resistance by attenuating ER stress. J Ethnopharmacol. 2020;259:112927. https://doi.org/10.1016/j.jep.2020.112927

Hong S-h, Hwang H-J, Kim JW, Kim JA, Lee YB, Roh E. Ginsenoside compound-Mc1 attenuates oxidative stress and apoptosis in cardiomyocytes through an AMP-activated protein kinase-dependent mechanism. J Ginseng Res. 2020;44(4):664-71. https://doi.org/10.1016/j.jgr.2019.08.006

Hao Wang, Jiali Zhu, Zhe Jia, Sucai Lu. Pretreatment of diabetic aged rats with combination of ginsenoside-Mc1 and silibinin protects liver from ischemia-reperfusion injury through an AMPK-dependent mechanism. Turk J Biochem. 2022;47(1):23-32. https://doi.org/10.1515/tjb-2021-0010

Li Z, Cui L. Application of TC index location on Longa's animal model of regional experimental cerebral ischemia and reperfusion. Chin J integr Tradit West Med. 2006;26 Suppl:18-20:18-20

Walcott BP, Kahle KT, Simard JM. Novel treatment targets for cerebral edema. Neurotherapeutics. 2012;9(1):65-72. https://doi.org/10.1007/s13311-011-0087-4

Zechariah A, ElAli A, Hagemann N, Jin F, Doeppner TR, Helfrich I. Hyperlipidemia attenuates vascular endothelial growth factor-induced angiogenesis, impairs cerebral blood flow, and disturbs stroke recovery via decreased pericyte coverage of brain endothelial cells. Arterioscler Thromb Vasc Biol. 2013;33(7):1561-7. https://doi.org/10.1161/ATVBAHA.112.300749

Kloska A, Malinowska M, Gabig-Cimińska M, Jakóbkiewicz-Banecka J. Lipids and lipid mediators associated with the risk and pathology of ischemic stroke. Int J Mol Sci. 2020;21(10):3618. https://doi.org/10.3390/ijms21103618

Hou W, Wang Y, Zheng P, Cui R. Effects of Ginseng on Neurological Disorders. Front Cell Neurosci. 2020;14:55. https://doi.org/10.3389/fncel.2020.00055

Liu M, Yu S, Wang J, Qiao J, Liu Y, Wang S. Ginseng protein protects against mitochondrial dysfunction and neurodegeneration by inducing mitochondrial unfolded protein response in Drosophila melanogaster PINK1 model of Parkinson's disease. J Ethnopharmacol. 2020;247:112213. https://doi.org/10.1016/j.jep.2019.112213

Naoi M, Wu Y, Shamoto-Nagai M, Maruyama W. Mitochondria in neuroprotection by phytochemicals: Bioactive polyphenols modulate mitochondrial apoptosis system, function and structure. Int J Mol Sci. 2019;20(10):2451. https://doi.org/10.3390/ijms20102451

Pereira O Jr, Kowaltowski AJ. Mitochondrial K+ Transport: Modulation and Functional Consequences. Molecules. 2021;26(10):2935. https://doi.org/10.3390/molecules26102935

Xia M, Zhang Y, Jin K. Communication between mitochondria and other organelles: a brand-new perspective on mitochondria in cancer. Cell Biosci. 2019;9:27. https://doi.org/10.1186/s13578-019-0289-8

Ouyang Y-B, Giffard RG. ER-mitochondria crosstalk during cerebral ischemia: molecular chaperones and ER-mitochondrial calcium transfer. Int J Cell Biol. 2012;2012:493934. https://doi.org/10.1155/2012/493934

Finkel T, Menazza S, Holmström KM, Parks RJ, Liu J, Sun J. The ins and outs of mitochondrial calcium. Circ Res. 2015;116(11):1810-9. https://doi.org/10.1161/CIRCRESAHA.116.305484

Cao SS, Kaufman RJ. Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease. Antioxid Redox Signal. 2014;21(3):396-413. https://doi.org/10.1089/ars.2014.5851

Szabò I, Leanza L, Gulbins E, Zoratti M. Physiology of potassium channels in the inner membrane of mitochondria. Pflugers Arch. 2012;463(2):231-46. https://doi.org/10.1007/s00424-011-1058-7

留言 (0)

沒有登入
gif