Influenza a virus triggers acute exacerbation of chronic obstructive pulmonary disease by increasing proinflammatory cytokines secretion via NLRP3 inflammasome activation

Rabe KF, Watz H. Chronic obstructive pulmonary disease. Lancet (London, England). 2017;389(10082):1931–40.

Article  Google Scholar 

D. Singh, A. Agusti, A. Anzueto, P.J. Barnes, J. Bourbeau, B.R. Celli, G.J. Criner, P. Frith, D.M.G. Halpin, M. Han, M.V. Lopez Varela, F. Martinez, M. Montes de Oca, A. Papi, I.D. Pavord, N. Roche, D.D. Sin, R. Stockley, J. Vestbo, J.A. Wedzicha, C. Vogelmeier, Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease: the GOLD science committee report 2019, The European respiratory journal 53(5) (2019).

Koul PA, Mir H, Akram S, Potdar V, Chadha MS. Respiratory viruses in acute exacerbations of chronic obstructive pulmonary disease. Lung India : official organ of Indian Chest Society. 2017;34(1):29–33.

Article  Google Scholar 

C. Viniol, C.F. Vogelmeier, Exacerbations of COPD, European respiratory review : an official journal of the European Respiratory Society 27(147) (2018).

Tisoncik JR, Korth MJ, Simmons CP, Farrar J, Martin TR, Katze MG. Into the eye of the cytokine storm. Microbiol Mol Biol Rev. 2012;76(1):16–32.

CAS  Article  Google Scholar 

Dai MY, Qiao JP, Xu YH, Fei GH. Respiratory infectious phenotypes in acute exacerbation of COPD: an aid to length of stay and COPD Assessment Test. Int J Chron Obstruct Pulmon Dis. 2015;10:2257–63.

PubMed  PubMed Central  Google Scholar 

J.C. Horvat, M.R. Starkey, R.Y. Kim, S. Phipps, P.G. Gibson, K.W. Beagley, P.S. Foster, P.M. Hansbro, Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology, The Journal of allergy and clinical immunology 125(3) (2010) 617–25, 625.e1–625.e6.

Hale D. Influenza 101: what you need to know. Home Healthc Nurse. 2014;32(9):525–30.

Article  Google Scholar 

Mizgerd JP. Acute lower respiratory tract infection. N Engl J Med. 2008;358(7):716–27.

CAS  Article  Google Scholar 

Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell. 2010;140(6):805–20.

CAS  Article  Google Scholar 

Iwasaki A, Pillai PS. Innate immunity to influenza virus infection. Nat Rev Immunol. 2014;14(5):315–28.

CAS  Article  Google Scholar 

Ichinohe T, Lee HK, Ogura Y, Flavell R, Iwasaki A. Inflammasome recognition of influenza virus is essential for adaptive immune responses. J Exp Med. 2009;206(1):79–87.

CAS  Article  Google Scholar 

Rohde G, Wiethege A, Borg I, Kauth M, Bauer TT, Gillissen A, Bufe A, Schultze-Werninghaus G. Respiratory viruses in exacerbations of chronic obstructive pulmonary disease requiring hospitalisation: a case-control study. Thorax. 2003;58(1):37–42.

CAS  Article  Google Scholar 

Fulcher ML, Gabriel S, Burns KA, Yankaskas JR, Randell SH. Well-differentiated human airway epithelial cell cultures. Methods Mol Med. 2005;107:183–206.

CAS  PubMed  Google Scholar 

Yamaya M, Nishimura H, Hatachi Y, Yoshida M, Fujiwara H, Asada M, Nakayama K, Yasuda H, Deng X, Sasaki T, Kubo H, Nagatomi R. Procaterol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells. Eur J Pharmacol. 2011;650(1):431–44.

CAS  Article  Google Scholar 

Ji S, Lin W, Wang L, Ni Z, Jin F, Zha X, Fei G. Combined Targeting of mTOR and Akt Using Rapamycin and MK-2206 in The Treatment of Tuberous Sclerosis Complex. J Cancer. 2017;8(4):555–62.

CAS  Article  Google Scholar 

Ji S, Bai Q, Wu X, Zhang DW, Wang S, Shen JL, et al. Unique synergistic antiviral effects of Shufeng Jiedu Capsule and oseltamivir in influenza A viral-induced acute exacerbation of chronic obstructive pulmonary disease. Biomed Pharmacother. 2020;121:109652.

Coll RC, Robertson AA, Chae JJ, Higgins SC, Munoz-Planillo R, Inserra MC, Vetter I, Dungan LS, Monks BG, Stutz A, Croker DE, Butler MS, Haneklaus M, Sutton CE, Nunez G, Latz E, Kastner DL, Mills KH, Masters SL, Schroder K, Cooper MA, O’Neill LA. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med. 2015;21(3):248–55.

CAS  Article  Google Scholar 

W. Gao, L. Li, Y. Wang, S. Zhang, I.M. Adcock, P.J. Barnes, M. Huang, X. Yao, Bronchial epithelial cells: The key effector cells in the pathogenesis of chronic obstructive pulmonary disease?, Respirology (Carlton, Vic.) 20(5) (2015) 722–9.

Tate MD, Ong JDH, Dowling JK, McAuley JL, Robertson AB, Latz E, Drummond GR, Cooper MA, Hertzog PJ, Mansell A. Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition. Sci Rep. 2016;6:27912.

CAS  Article  Google Scholar 

Coates BM, Staricha KL, Ravindran N, Koch CM, Cheng Y, Davis JM, Shumaker DK, Ridge KM. Inhibition of the NOD-Like Receptor Protein 3 Inflammasome Is Protective in Juvenile Influenza A Virus Infection. Front Immunol. 2017;8:782.

Article  Google Scholar 

Jia X, Liu B, Bao L, Lv Q, Li F, Li H, An Y, Zhang X, Cao B, Wang C. Delayed oseltamivir plus sirolimus treatment attenuates H1N1 virus-induced severe lung injury correlated with repressed NLRP3 inflammasome activation and inflammatory cell infiltration. PLoS Pathog. 2018;14(11):e1007428.

Article  Google Scholar 

Monto AS, Gravenstein S, Elliott M, Colopy M, Schweinle J. Clinical signs and symptoms predicting influenza infection. Arch Intern Med. 2000;160(21):3243–7.

CAS  Article  Google Scholar 

Allen IC, Scull MA, Moore CB, Holl EK, McElvania-TeKippe E, Taxman DJ, Guthrie EH, Pickles RJ, Ting JP. The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA. Immunity. 2009;30(4):556–65.

CAS  Article  Google Scholar 

Thomas PG, Dash P, Aldridge JR Jr, Ellebedy AH, Reynolds C, Funk AJ, Martin WJ, Lamkanfi M, Webby RJ, Boyd KL, Doherty PC, Kanneganti TD. The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Immunity. 2009;30(4):566–75.

CAS  Article  Google Scholar 

McAuley JL, Tate MD, MacKenzie-Kludas CJ, Pinar A, Zeng W, Stutz A, Latz E, Brown LE, Mansell A. Activation of the NLRP3 inflammasome by IAV virulence protein PB1-F2 contributes to severe pathophysiology and disease. PLoS Pathog. 2013;9(5):e1003392.

CAS  Article  Google Scholar 

M.J. Primiano, B.A. Lefker, M.R. Bowman, A.G. Bree, C. Hubeau, P.D. Bonin, M. Mangan, K. Dower, B.G. Monks, L. Cushing, S. Wang, J. Guzova, A. Jiao, L.L. Lin, E. Latz, D. Hepworth, J.P. Hall, Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation, Journal of immunology (Baltimore, Md. : 1950) 197(6) (2016) 2421–33.

Herold S, Becker C, Ridge KM, Budinger GR. Influenza virus-induced lung injury: pathogenesis and implications for treatment. Eur Respir J. 2015;45(5):1463–78.

CAS  Article  Google Scholar 

Liu X, Shen J, Fan D, Qiu X, Guo Q, Zheng K, Luo H, Shu J, Lu C, Zhang G, Lu A, Ma C, He X. Yupingfeng San Inhibits NLRP3 Inflammasome to Attenuate the Inflammatory Response in Asthma Mice. Front Pharmacol. 2017;8:944.

Article  Google Scholar 

S. Lee, M. Hirohama, M. Noguchi, K. Nagata, A. Kawaguchi, Influenza A Virus Infection Triggers Pyroptosis and Apoptosis of Respiratory Epithelial Cells through the Type I Interferon Signaling Pathway in a Mutually Exclusive Manner, Journal of virology 92(14) (2018).

Wang ML, Kang YM, Li XG, Su Q, Li HB, Liu KL, Fu LY, Saahene RO, Li Y, Tan H, Yu XJ. Central blockade of NLRP3 reduces blood pressure via regulating inflammation microenvironment and neurohormonal excitation in salt-induced prehypertensive rats. J Neuroinflammation. 2018;15(1):95.

Article  Google Scholar 

Xu X, Yin D, Ren H, Gao W, Li F, Sun D, Wu Y, Zhou S, Lyu L, Yang M, Xiong J, Han L, Jiang R, Zhang J. Selective NLRP3 inflammasome inhibitor reduces neuroinflammation and improves long-term neurological outcomes in a murine model of traumatic brain injury. Neurobiol Dis. 2018;117:15–27.

CAS  Article  Google Scholar 

Guo H, Callaway JB, Ting JP. Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat Med. 2015;21(7):677–87.

Article  Google Scholar 

A. Weber, P. Wasiliew, M. Kracht, Interleukin-1 (IL-1) pathway, Science signaling 3(105) (2010) cm1.

R. Faner, P. Sobradillo, A. Noguera, C. Gomez, T. Cruz, A. Lopez-Giraldo, E. Ballester, N. Soler, J.I. Arostegui, P. Pelegrin, R. Rodriguez-Roisin, J. Yague, B.G. Cosio, M. Juan, A. Agusti, The inflammasome pathway in stable COPD and acute exacerbations, ERJ open research 2(3) (2016).

Wang H, Lv C, Wang S, Ying H, Weng Y, Yu W. NLRP3 Inflammasome Involves in the Acute Exacerbation of Patients with Chronic Obstructive Pulmonary Disease. Inflammation. 2018;41(4):1321–33.

CAS  Article  Google Scholar 

Imaoka H, Hoshino T, Takei S, Kinoshita T, Okamoto M, Kawayama T, Kato S, Iwasaki H, Watanabe K, Aizawa H. Interleukin-18 production and pulmonary function in COPD. Eur Respir J. 2008;31(2):287–97.

CAS  Article  Google Scholar 

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