Amphicrine Medullary Thyroid Carcinoma — a Case-Based Review Expanding on Its MUC Expression Profile

Wells SA, Asa SL, Dralle H et al. (2015) Revised American Thyroid Association Guidelines for the Management of Medullary Thyroid Carcinoma. Thyroid 25:567–610. https://doi.org/10.1089/thy.2014.0335

Article  PubMed  PubMed Central  Google Scholar 

Randle RW, Balentine CJ, Leverson GE et al. (2017) Trends in the presentation, treatment, and survival of patients with medullary thyroid cancer over the past 30 years. Surgery 161:137–146. https://doi.org/10.1016/j.surg.2016.04.053

Article  PubMed  Google Scholar 

Zaatari GS, Saigo PE, Huvos AG (1983) Mucin production in medullary carcinoma of the thyroid. Arch Pathol Lab Med 107:70–74

CAS  PubMed  Google Scholar 

Farhat NA, Onenerk AM, Krane JF et al. (2017) Primary Benign and Malignant Thyroid Neoplasms With Signet Ring Cells: Cytologic, Histologic, and Molecular Features. American Journal of Clinical Pathology 148:251–258. https://doi.org/10.1093/ajcp/aqx074

CAS  Article  PubMed  Google Scholar 

Mlynek M-L, Richter HJ, Leder L-D (1985) Mucin in carcinomas of the thyroid. Cancer 56:2647–2650. https://doi.org/10.1002/1097-0142(19851201)56:11<2647::AID-CNCR2820561119>3.0.CO;2-8

CAS  Article  PubMed  Google Scholar 

Golouh R, Us-krasovec, Auersperg et al. (1985) Amphicrine — Composite Calcitonin and Mucin-Producing — Carcinoma of the Thyroid. Ultrastructural Pathology 8:197–206. https://doi.org/10.3109/01913128509142153

CAS  Article  PubMed  Google Scholar 

Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O. Overview of the 2022 WHO Classification of Thyroid Neoplasms. Endocr Pathol. 2022 Mar;33(1):27-63.

Article  Google Scholar 

Haleem A, Akhtar M, Ali MA, Iqbal Z (1990) Fine-needle aspiration biopsy of mucus-producing medullary carcinoma of thyroid: Report of a case with cytologic, histologic, and ultrastructural correlations. Diagnostic Cytopathology 6:112–117. https://doi.org/10.1002/dc.2840060208

CAS  Article  PubMed  Google Scholar 

Dominguez-Malagon H, Macias-Martinez V, Molina-Cardenas H, Suster S (1997) Amphicrine Medullary Carcinoma of the Thyroid with Luminal Differentiation: Report of an Immunohistochemical and Ultrastructural Study. Ultrastructural Pathology 21:569–574. https://doi.org/10.3109/01913129709016373

CAS  Article  PubMed  Google Scholar 

Osaka M, Soga J, Tamiya Y, Suzuki T (1999) Dedifferentiation of neoplastic cells in medullary thyroid carcinoma: report of a case. Surg Today 29:1189–1194. https://doi.org/10.1007/BF02482271

CAS  Article  PubMed  Google Scholar 

Kinjo M, Yohena C, Kunishima N (2003) Intracytoplasmic Lumina in Medullary Carcinoma of the Thyroid Gland. Acta Cytologica 47:663–667. https://doi.org/10.1159/000326585

Article  PubMed  Google Scholar 

Mardi K (2021) Cytodiagnosis of mucin-producing medullary carcinoma of the thyroid gland. South Asian J Cancer 02:210–210

Google Scholar 

Dhanisha SS, Guruvayoorappan C, Drishya S, Abeesh P (2018) Mucins: Structural diversity, biosynthesis, its role in pathogenesis and as possible therapeutic targets. Critical Reviews in Oncology/Hematology 122:98–122. https://doi.org/10.1016/j.critrevonc.2017.12.006

Article  PubMed  Google Scholar 

Lau SK, Weiss LM, Chu PG (2004) Differential expression of MUC1, MUC2, and MUC5AC in carcinomas of various sites: an immunohistochemical study. Am J Clin Pathol 122:61–69. https://doi.org/10.1309/9R66-73QE-C06D-86Y4

Article  PubMed  Google Scholar 

Ho SB, Shekels LL, Toribara NW et al. (1995) Mucin Gene Expression in Normal, Preneoplastic, and Neoplastic Human Gastric Epithelium. Cancer Res 55:2681

CAS  PubMed  Google Scholar 

Wang X-T, Kong F-B, Mai W et al. (2016) MUC1 Immunohistochemical Expression as a Prognostic Factor in Gastric Cancer: Meta-Analysis. Dis Markers 2016:9421571. https://doi.org/10.1155/2016/9421571

CAS  Article  PubMed  PubMed Central  Google Scholar 

Jing X, Liang H, Hao C et al. (2019) Overexpression of MUC1 predicts poor prognosis in patients with breast cancer. Oncology Reports 41:801–810. https://doi.org/10.3892/or.2018.6887

CAS  Article  PubMed  Google Scholar 

Do S-I, Kim K, Kim D-H et al. (2013) Associations between the Expression of Mucins (MUC1, MUC2, MUC5AC, and MUC6) and Clinicopathologic Parameters of Human Breast Ductal Carcinomas. J Breast Cancer 16:152–158. https://doi.org/10.4048/jbc.2013.16.2.152

Article  PubMed  PubMed Central  Google Scholar 

Betge J, Schneider NI, Harbaum L et al. (2016) MUC1, MUC2, MUC5AC, and MUC6 in colorectal cancer: expression profiles and clinical significance. Virchows Arch 469:255–265. https://doi.org/10.1007/s00428-016-1970-5

CAS  Article  PubMed  PubMed Central  Google Scholar 

Wang J, Guli Q-R, Ming X-C et al. (2018) Primary mucinous carcinoma of thyroid gland with prominent signet-ring-cell differentiation: a case report and review of the literature. Onco Targets Ther 11:1521–1528. https://doi.org/10.2147/OTT.S158975

CAS  Article  PubMed  PubMed Central  Google Scholar 

Alves P, Soares P, Fonseca E, Sobrinho-Simões M (1999) Papillary thyroid carcinoma overexpresses fully and underglycosylated mucins together with native and sialylated simple mucin antigens and histo-blood group antigens. Endocr Pathol 10:315–324. https://doi.org/10.1007/BF02739774

CAS  Article  PubMed  Google Scholar 

Bèche I, Ruffet E, Zweibaum A et al. (1997) MUC1 Mucin Gene, Transcripts, and Protein in Adenomas and Papillary Carcinomas of the Thyroid. Thyroid 7:725–731. https://doi.org/10.1089/thy.1997.7.725

Article  Google Scholar 

Li Q, Jin W-X, Jin Y-X et al. (2018) Clinical effect of MUC1 and its relevance to BRAF V600E mutation in papillary thyroid carcinoma: a case–control study. Cancer Manag Res 10:1351–1358. https://doi.org/10.2147/CMAR.S161501

CAS  Article  PubMed  PubMed Central  Google Scholar 

Renaud F, Gnemmi V, Devos P et al. (2014) MUC1 Expression in Papillary Thyroid Carcinoma Is Associated with BRAF Mutation and Lymph Node Metastasis; the Latter is the Most Important Risk Factor of Relapse. Thyroid 24:1375–1384. https://doi.org/10.1089/thy.2013.0594

CAS  Article  PubMed  Google Scholar 

Li Y, Gao W, Cai X et al. (2021) Exploring Somatic Alteration Associating With Aggressive Behaviors of Papillary Thyroid Carcinomas by Targeted Sequencing. Frontiers in Oncology 11:4029. https://doi.org/10.3389/fonc.2021.722814

Article  Google Scholar 

Farahmand L, Merikhian P, Jalili N et al. (2018) Significant Role of MUC1 in Development of Resistance to Currently Existing Anti-cancer Therapeutic Agents. Curr Cancer Drug Targets 18:737–748. https://doi.org/10.2174/1568009617666170623113520

CAS  Article  PubMed  Google Scholar 

Pillai K, Pourgholami MH, Chua TC, Morris DL (2015) MUC1 as a Potential Target in Anticancer Therapies. American Journal of Clinical Oncology 38:108–118. https://doi.org/10.1097/COC.0b013e31828f5a07

CAS  Article  PubMed  Google Scholar 

留言 (0)

沒有登入
gif