Alzheimer’s Association. Alzheimer’s disease facts and figures. Alzheimer’s & Dementia. 2019;2019(15):321–87.
Eshkoor SA, Hamid TA, Mun CY, Ng CK. Mild cognitive impairment and its management in older people. Clin Interv Aging. 2015;10:687–93.
PubMed PubMed Central Article Google Scholar
Kelley BJ, Petersen RC. Alzheimer’s Disease and Mild Cognitive Impairment. Neurol Clin. 2007;25:577–609.
PubMed PubMed Central Article Google Scholar
Tiwari S, Atluri V, Kaushik A, Yndart A, Nair M. Alzheimer’s disease: pathogenesis, diagnostics, and therapeutics. Int J Nanomedicine. 2019;14:5541–54.
CAS PubMed PubMed Central Article Google Scholar
Kivipelto M, Helkala E-L, Laakso MP, Hänninen T, Hallikainen M, Alhainen K, et al. Midlife vascular risk factors and Alzheimer’s disease in later life: longitudinal, population based study. BMJ British Medical Journal Publishing Group. 2001;322:1447–51.
Balagopal PB, de Ferranti SD, Cook S, Daniels SR, Gidding SS, Hayman LL, et al. Nontraditional risk factors and biomarkers for cardiovascular disease: mechanistic, research, and clinical considerations for youth. Circulation. American Heart Association. 2011;123:2749–69.
Reitz C, Tang M-X, Manly J, Mayeux R, Luchsinger JA. Hypertension and the Risk of Mild Cognitive Impairment. Arch Neurol. 2007;64:1734–40.
PubMed PubMed Central Article Google Scholar
Profenno LA, Porsteinsson AP, Faraone SV. Meta-Analysis of Alzheimer’s Disease Risk with Obesity, Diabetes, and Related Disorders. Biol Psychiat. 2010;67:505–12.
Moheet A, Mangia S, Seaquist E. Impact of diabetes on cognitive function and brain structure. Ann N Y Acad Sci. 2015;1353:60–71.
PubMed PubMed Central Article Google Scholar
Knopman D, Boland LL, Mosley T, Howard G, Liao D, Szklo M, et al. Cardiovascular risk factors and cognitive decline in middle-aged adults. Neurology. Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. 2001;56:42–8.
Dye L, Boyle NB, Champ C, Lawton C. The relationship between obesity and cognitive health and decline. Proceedings of the Nutrition Society. Cambridge University Press. 2017;76:443–54.
Goldstein FC, Ashley AV, Endeshaw Y, Hanfelt J, Lah JJ, Levey AI. Effects of Hypertension and Hypercholesterolemia on Cognitive Functioning in Patients with Alzheimer’s Disease. Alzheimer Dis Assoc Disord. 2008;22:336–42.
PubMed PubMed Central Article Google Scholar
Livingston G, Huntley J, Sommerlad A, Ames D, Ballard C, Banerjee S, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020;396:413–46.
PubMed PubMed Central Article Google Scholar
Nutaitis AC, Tharwani SD, Serra MC, Goldstein FC, Zhao L, Sher SS, et al. Diet as a Risk Factor for Cognitive Decline in African Americans and Caucasians with a Parental History of Alzheimer’s Disease: A Cross-Sectional Pilot Study Dietary Patterns. J Prev Alzheimers Dis. 2019;6:50–5.
Gareau MG. Microbiota-Gut-Brain Axis and Cognitive Function. In: Lyte M, Cryan JF, editors. Microbial Endocrinology: The Microbiota-Gut-Brain Axis in Health and Disease. New York, NY: Springer; 2014. p. 357–71.
Berg G, Rybakova D, Fischer D, Cernava T, Vergès M-CC, Charles T, et al. Microbiome definition re-visited: old concepts and new challenges. Microbiome. 2020;8:103.
Chelakkot C, Ghim J, Ryu SH. Mechanisms regulating intestinal barrier integrity and its pathological implications. Exp Mol Med Nature Publishing Group. 2018;50:1–9.
Mayer EA, Knight R, Mazmanian SK, Cryan JF, Tillisch K. Gut Microbes and the Brain: Paradigm Shift in Neuroscience. J Neurosci. 2014;34:15490–6.
PubMed PubMed Central Article Google Scholar
Bonaz B, Bazin T, Pellissier S. The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis. Front Neurosci. 2018;12:49.
PubMed PubMed Central Article Google Scholar
Donaldson GP, Lee SM, Mazmanian SK. Gut biogeography of the bacterial microbiota. Nat Rev Microbiol. 2016;14:20–32.
CAS PubMed Article Google Scholar
Donaldson GP, Lee SM, Mazmanian SK. Gut biogeography of the bacterial microbiota. Nat Rev Microbiol Nature Publishing Group. 2016;14:20–32.
Rothschild D, Weissbrod O, Barkan E, Kurilshikov A, Korem T, Zeevi D, et al. Environment dominates over host genetics in shaping human gut microbiota. Nature Nature Publishing Group. 2018;555:210–5.
Ling Z, Zhu M, Yan X, Cheng Y, Shao L, Liu X, et al. Structural and Functional Dysbiosis of Fecal Microbiota in Chinese Patients With Alzheimer’s Disease. Frontiers in Cell and Developmental Biology. 2021;8: 634069.
PubMed PubMed Central Article Google Scholar
Liu S, Gao J, Zhu M, Liu K, Zhang H-L. Gut Microbiota and Dysbiosis in Alzheimer’s Disease: Implications for Pathogenesis and Treatment. Mol Neurobiol. 2020;57:5026–43.
CAS PubMed PubMed Central Article Google Scholar
Li B, He Y, Ma J, Huang P, Du J, Cao L, et al. Mild cognitive impairment has similar alterations as Alzheimer’s disease in gut microbiota. Alzheimer’s & Dementia. 2019;15:1357–66.
Liu P, Wu L, Peng G, Han Y, Tang R, Ge J, et al. Altered microbiomes distinguish Alzheimer’s disease from amnestic mild cognitive impairment and health in a Chinese cohort. Brain Behav Immun. 2019;80:633–43.
Zhang X, Wang Y, Liu W, Wang T, Wang L, Hao L, et al. Diet quality, gut microbiota, and microRNAs associated with mild cognitive impairment in middle-aged and elderly Chinese population. Am J Clin Nutr. 2021;114:429–40.
Nagpal R, Neth BJ, Wang S, Mishra SP, Craft S, Yadav H. Gut mycobiome and its interaction with diet, gut bacteria and alzheimer’s disease markers in subjects with mild cognitive impairment: A pilot study. EBioMedicine. 2020;59: 102950.
CAS PubMed PubMed Central Article Google Scholar
Saji N, Murotani K, Hisada T, Tsuduki T, Sugimoto T, Kimura A, et al. The relationship between the gut microbiome and mild cognitive impairment in patients without dementia: a cross-sectional study conducted in Japan. Sci Rep. Nature Publishing Group. 2019;9:19227.
Bostanciklioğlu M. The role of gut microbiota in pathogenesis of Alzheimer’s disease. J Appl Microbiol. 2019;127:954–67.
Visconti A, Le Roy CI, Rosa F, Rossi N, Martin TC, Mohney RP, et al. Interplay between the human gut microbiome and host metabolism. Nat Commun. 2019;10:4505.
PubMed PubMed Central Article CAS Google Scholar
Lubinski R. Dementia and communication. Singular. 1995.
Murman DL. The Impact of Age on Cognition. Semin Hear. 2015;36:111–21.
PubMed PubMed Central Article Google Scholar
Mortamet B, Zeng D, Gerig G, Prastawa M, Bullitt E. Effects of Healthy Aging Measured By Intracranial Compartment Volumes Using a Designed MR Brain Database. Med Image Comput Comput Assist Interv. 2005;8:383–91.
PubMed PubMed Central Google Scholar
Scahill RI, Frost C, Jenkins R, Whitwell JL, Rossor MN, Fox NC. A longitudinal study of brain volume changes in normal aging using serial registered magnetic resonance imaging. Arch Neurol. 2003;60:989–94.
Deary IJ, Corley J, Gow AJ, Harris SE, Houlihan LM, Marioni RE, et al. Age-associated cognitive decline. Br Med Bull. 2009;92:135–52.
Raz N, Rodrigue KM. Differential aging of the brain: Patterns, cognitive correlates and modifiers. Neurosci Biobehav Rev. 2006;30:730–48.
PubMed PubMed Central Article Google Scholar
Sullivan EV, Pfefferbaum A. Diffusion tensor imaging and aging. Neurosci Biobehav Rev. 2006;30:749–61.
Bolandzadeh N, Davis JC, Tam R, Handy TC, Liu-Ambrose T. The association between cognitive function and white matter lesion location in older adults: a systematic review. BMC Neurol. 2012;12:126.
PubMed PubMed Central Article Google Scholar
Alexander GE, Bergfield KL, Chen K, Reiman EM, Hanson KD, Lin L, et al. Gray matter network associated with risk for Alzheimer’s disease in young to middle-aged adults. Neurobiol Aging. 2012;33:2723–32.
PubMed PubMed Central Article Google Scholar
Irwin K, Sexton C, Daniel T, Lawlor B, Naci L. Healthy Aging and Dementia: Two Roads Diverging in Midlife? Front Aging Neurosci. 2018;10:275.
PubMed PubMed Central Article Google Scholar
Adluru N, Destiche DJ, Lu SY-F, Doran ST, Birdsill AC, Melah KE, et al. White matter microstructure in late middle-age: Effects of apolipoprotein E4 and parental family history of Alzheimer’s disease. Neuroimage Clin. 2014;4:730–42.
Persson J, Lind J, Larsson A, Ingvar M, Cruts M, Van Broeckhoven C, et al. Altered brain white matter integrity in healthy carriers of the APOE epsilon4 allele: a risk for AD? Neurology. 2006;66:1029–33.
CAS PubMed Article Google Scholar
Heise V, Filippini N, Ebmeier KP, Mackay CE. The APOE ɛ4 allele modulates brain white matter integrity in healthy adults. Mol Psychiatry. 2011;16:908–16.
CAS PubMed Article Google Scholar
Miller MI, Ratnanather JT, Tward DJ, Brown T, Lee DS, Ketcha M, et al. Network Neurodegeneration in Alzheimer’s Disease via MRI Based Shape Diffeomorphometry and High-Field Atlasing. Frontiers in Bioengineering and Biotechnology. 2015;3:54.
PubMed PubMed Central Article Google Scholar
Thompson PM, Hayashi KM, De Zubicaray GI, Janke AL, Rose SE, Semple J, et al. Mapping hippocampal and ventricular change in Alzheimer disease. Neuroimage. 2004;22:1754–66.
Jacobs HIL, Becker JA, Kwong K, Engels-Domínguez N, Prokopiou PC, Papp KV, et al. In vivo and ne
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