Neutralizing antibodies and their cocktails against SARS-CoV-2 Omicron and other circulating variants

Jiang S, Zhang X, Du L. Therapeutic antibodies and fusion inhibitors targeting the spike protein of SARS-CoV-2. Expert Opin Ther Targets. 2021;25:415–21.

CAS  Article  Google Scholar 

Du L, Yang Y, Zhang X. Neutralizing antibodies for the prevention and treatment of COVID-19. Cell Mol Immunol. 2021;18:2293–306.

CAS  Article  Google Scholar 

Tai W, He L, Zhang X, Pu J, Voronin D, Jiang S, et al. Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine. Cell Mol Immunol. 2020;17:613–20.

CAS  Article  Google Scholar 

World Health Organization. Tracking SARS-CoV-2 variants. Updated on 30 Aug. 2022. https://www.who.int/activities/tracking-SARS-CoV-2-variants.

McCallum M, Czudnochowski N, Rosen LE, Zepeda SK, Bowen JE, Walls AC, et al. Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement. Science 2022;375:864–8.

CAS  Article  Google Scholar 

Ye G, Liu B, Li F. Cryo-EM structure of a SARS-CoV-2 omicron spike protein ectodomain. Nat Commun. 2022;13:1214.

CAS  Article  Google Scholar 

Han P, Li L, Liu S, Wang Q, Zhang D, Xu Z, et al. Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2. Cell 2022;185:630–40. e10

CAS  Article  Google Scholar 

Mannar D, Saville JW, Zhu X, Srivastava SS, Berezuk AM, Tuttle KS, et al. SARS-CoV-2 Omicron variant: antibody evasion and cryo-EM structure of spike protein-ACE2 complex. Science 2022;375:760–4.

CAS  Article  Google Scholar 

Zhou T, Wang L, Misasi J, Pegu A, Zhang Y, Harris DR, et al. Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B.1.1.529. Science 2022;376:eabn8897.

CAS  Article  Google Scholar 

Bruel T, Hadjadj J, Maes P, Planas D, Seve A, Staropoli I, et al. Serum neutralization of SARS-CoV-2 Omicron sublineages BA.1 and BA.2 in patients receiving monoclonal antibodies. Nat Med. 2022. https://doi.org/10.1038/s41591-022-01792-5.

Starr TN, Czudnochowski N, Liu Z, Zatta F, Park YJ, Addetia A, et al. SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape. Nature 2021;597:97–102.

CAS  Article  Google Scholar 

Hingankar N, Deshpande S, Das P, Rizvi ZA, Wibmer CK, Mashilo P, et al. A combination of potently neutralizing monoclonal antibodies isolated from an Indian convalescent donor protects against the SARS-CoV-2 Delta variant. PLoS Pathog. 2022;18:e1010465.

CAS  Article  Google Scholar 

Cameroni E, Bowen JE, Rosen LE, Saliba C, Zepeda SK, Culap K, et al. Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift. Nature 2022;602:664–70.

CAS  Article  Google Scholar 

Zhang X, Luo F, Zhang H, Guo H, Zhou J, Li T, et al. A cocktail containing two synergetic antibodies broadly neutralizes SARS-CoV-2 and its variants including Omicron BA.1 and BA.2. bioRxiv [Preprint]. 2022. Available from https://doi.org/10.1101/2022.04.26.489529.

VanBlargan LA, Errico JM, Halfmann PJ, Zost SJ, Crowe JE, Purcell LA, et al. An infectious SARS-CoV-2 B.1.1.529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies. Nat Med. 2022;28:490–5.

CAS  Article  Google Scholar 

O’Brien MP, Forleo-Neto E, Sarkar N, Isa F, Hou P, Chan KC, et al. Effect of subcutaneous casirivimab and imdevimab antibody combination vs placebo on development of symptomatic COVID-19 in early asymptomatic SARS-CoV-2 infection: a randomized clinical trial. JAMA 2022;327:432–41.

Article  Google Scholar 

Nguyen H, Lan PD, Nissley DA, O’Brien EP, Li MS. Cocktail of REGN antibodies binds more strongly to SARS-CoV-2 than its components, but the Omicron variant reduces its neutralizing ability. J Phys Chem B. 2022;126:2812–23.

CAS  Article  Google Scholar 

Tatham L, Sharp J, Kijak E, Herriott J, Neary M, Box H, et al. Lack of Ronapreve (REGN-CoV; casirivimab and imdevimab) virological efficacy against the SARS-CoV-2 Omicron variant (B.1.1.529) in K18-hACE2 mice. bioRxiv [Preprint]. 2022. Available from https://doi.org/10.1101/2022.01.23.477397.

留言 (0)

沒有登入
gif