Huang T, Asimi S, Lou D, Li D. Plasma phospholipid polyunsaturated fatty acids and homocysteine in Chinese type 2 diabetes patients. Asia Pac J Clin Nutr. 2012;21:394.

CAS  PubMed  Google Scholar 

Chokrungvaranon N, Deer J, Reaven PD. Intensive glycemic control and cardiovascular disease: are there patients who may benefit? Postgrad Med. 2011;123:114–23.

PubMed  Article  Google Scholar 

Sudchada P, Saokaew S, Sridetch S, Incampa S, Jaiyen S, Khaithong W. Effect of folic acid supplementation on plasma total homocysteine levels and glycemic control in patients with type 2 diabetes: a systematic review and meta-analysis. Diabetes Res Clin Pr. 2012;98:151–8.

CAS  Article  Google Scholar 

Li Y, Huang T, Zheng Y, Muka T, Troup J, Hu FB. Folic acid supplementation and the risk of cardiovascular diseases: a meta‐analysis of randomized controlled trials. J Am Heart Assoc. 2016;5:e003768.

PubMed  PubMed Central  Article  Google Scholar 

Werida RH, Omran A, El-Khodary NM. Sortilin and Homocysteine as Potential Biomarkers for Coronary Artery Diseases. Int J Gen Med. 2021;14:6167.

PubMed  PubMed Central  Article  Google Scholar 

Meigs JB, Jacques PF, Selhub J, Singer DE, Nathan DM, Rifai N, et al. Fasting plasma homocysteine levels in the insulin resistance syndrome: the Framingham offspring study. Diabetes Care. 2001;24:1403–10.

CAS  PubMed  Article  Google Scholar 

Gargari BP, Aghamohammadi V, Aliasgharzadeh A. Effect of folic acid supplementation on biochemical indices in overweight and obese men with type 2 diabetes. Diabetes Res Clin Pr. 2011;94:33–38.

CAS  Article  Google Scholar 

Ndrepepa G, Kastrati A, Braun S, Koch W, Kölling K, Mehilli J, et al. Circulating homocysteine levels in patients with type 2 diabetes mellitus. Nutr Metab Cardiovasc Dis. 2008;18:66–73.

CAS  PubMed  Article  Google Scholar 

Vijayakumar A, Kim E, Kim H, Choi YJ, Huh KB, Chang N. Effects of folic acid supplementation on serum homocysteine levels, lipid profiles, and vascular parameters in post-menopausal Korean women with type 2 diabetes mellitus. Nutr Res Pr. 2017;11:327–33.

CAS  Article  Google Scholar 

Aghamohammadi V, Gargari BP, Aliasgharzadeh A. Effect of folic acid supplementation on homocysteine, serum total antioxidant capacity, and malondialdehyde in patients with type 2 diabetes mellitus. J Am Coll Nutr. 2011;30:210–5. p

CAS  PubMed  Article  Google Scholar 

Ponziani FR, Cazzato IA, Danese S, Fagiuoli S, Gionchetti P, Annicchiarico BE, et al. Folate in gastrointestinal health and disease. Eur Rev Med Pharm Sci. 2012;16:376–85.

CAS  Google Scholar 

Sahin M, Tutuncu NB, Ertugrul D, Tanaci N, Guvener ND. Effects of metformin or rosiglitazone on serum concentrations of homocysteine, folate, and vitamin B12 in patients with type 2 diabetes mellitus. J Diabetes Complications. 2007;21:118–23.

PubMed  Article  Google Scholar 

Kundi H, Kiziltunc E, Ates I, Cetin M, Barca AN, Ozkayar N, et al. Association between plasma homocysteine levels and end-organ damage in newly diagnosed type 2 diabetes mellitus patients. Endocr Res. 2017;42:36–41.

CAS  PubMed  Article  Google Scholar 

Rains JL, Jain SK. Oxidative stress, insulin signaling, and diabetes. Free Radic Biol Med. 2011;50:567–75.

CAS  PubMed  Article  Google Scholar 

Joshi R, Adhikari S, Patro BS, Chattopadhyay S, Mukherjee T. Free radical scavenging behavior of folic acid: evidence for possible antioxidant activity. Free Radic Biol Med. 2001;30:1390–9.

CAS  PubMed  Article  Google Scholar 

Shah A, Mehta N, Reilly MP. Adipose inflammation, insulin resistance, and cardiovascular disease. J Parenter Enter Nutr. 2008;32:638–44.

CAS  Article  Google Scholar 

Bagherieh M, Kheirollahi A, Zamani-Garmsiri F, Emamgholipour S, Meshkani R. Folic acid ameliorates palmitate-induced inflammation through decreasing homocysteine and inhibiting NF-κB pathway in HepG2 cells. Arch Physiol Biochem. 2021;17:1–8.

Article  CAS  Google Scholar 

Timpson NJ, Lawlor DA, Harbord RM, Gaunt TR, Day INM, Palmer LJ, et al. C-reactive protein and its role in metabolic syndrome: mendelian randomisation study. Lancet. 2005;366:1954–9.

CAS  PubMed  Article  Google Scholar 

Bisoendial RJ, Boekholdt SM, Vergeer M, Stroes ESG, Kastelein JJP. C-reactive protein is a mediator of cardiovascular disease. Eur Heart J. 2010;31:2087–91.

CAS  PubMed  Article  Google Scholar 

Seo SM, Baek SH, Jeon HK, Kang SM, Kim DS, Kim WS, et al. Correlations between the level of high-sensitivity C-reactive protein and cardiovascular risk factors in Korean adults with cardiovascular disease or diabetes mellitus: the CALLISTO study. J Atheroscler Thromb. 2013;20:616–22.

CAS  PubMed  Article  Google Scholar 

Oh TJ, Ahn CH, Kim BR, Kim KM, Moon JH, Lim S, et al. Circulating sortilin level as a potential biomarker for coronary atherosclerosis and diabetes mellitus. Cardiovascular Diabetol. 2017;16:92.

Article  CAS  Google Scholar 

Biscetti F, Bonadia N, Santini F, Angelini F, Nardella E, Pitocco D, et al. Sortilin levels are associated with peripheral arterial disease in type 2 diabetic subjects. Cardiovascular Diabetol. 2019;18:5.

Article  Google Scholar 

Demir İ, Akan OY, Guler A, Bozkaya G, Aslanipour B, Calan M. Relation of decreased circulating sortilin levels with unfavorable metabolic profiles in subjects with newly diagnosed Type 2 diabetes mellitus. Am J Med Sci. 2020;359:8–16.

PubMed  Article  Google Scholar 

Goettsch C, Kjolby M, Aikawa E. Sortilin and its multiple roles in cardiovascular and metabolic diseases. Arterioscler Thromb Vasc Biol. 2018;38:19–25.

CAS  PubMed  Article  Google Scholar 

Ogawa K, Ueno T, Iwasaki T, Kujiraoka T, Ishihara M, Kunimoto S, et al. Soluble sortilin is released by activated platelets and its circulating levels are associated with cardiovascular risk factors. Atherosclerosis. 2016;249:110–5.

CAS  PubMed  Article  Google Scholar 

Schunkert H, König IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, et al. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet. 2011;43:333–8.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 2010;466:707–13.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Artha IMJR, Bhargah A, Dharmawan NK, Pande UW, Triyana KA, Mahariski PA, et al. High level of individual lipid profile and lipid ratio as a predictive marker of poor glycemic control in type-2 diabetes mellitus. Vasc Health Risk Manag. 2019;15:149.

PubMed  PubMed Central  Article  Google Scholar 

Prochaska, J, Gellman M, Turner J. Encyclopedia of behavioral medicine. New York: Springer; 2013;1–136.

Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499–502.

CAS  PubMed  Article  Google Scholar 

Ajabnoor M, AL-Ama MN, Banjar Z, Rafee AA, Sheweita SA. Homocysteine level and other biochemical parameters in cardiovascular disease patients with diabetes mellitus. Med Sci Monit. 2003;9:CR523–27.

CAS  PubMed  Google Scholar 

Clarke R, Frost J, Sherliker P, Lewington S, Collins R, Brattstrom L, et al. Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials. Am J Clin Nutr. 2005;82:806–12.

CAS  Article  Google Scholar 

Mashavi M, Hanah R, Boaz M, Gavish D, Matas Z, Fux A, et al. Effect of homocysteine-lowering therapy on arterial elasticity and metabolic parameters in metformin-treated diabetic patients. Atherosclerosis. 2008;199:362–7.

CAS  PubMed  Article  Google Scholar 

Yegnanarayan R, Suryavanshi M, Singh M, Desai S. A comparative study of the glycemic control of various antidiabetic agents and the role of homocysteine in the therapy of type 2 diabetes mellitus. J Diabetes Complications. 2008;22:104–11.

PubMed  Article  Google Scholar 

Van Ede AE, Laan RF, Blom HJ, Boers GH, Haagsma CJ, Thomas CM, et al. Homocysteine and folate status in methotrexate‐treated patients with rheumatoid arthritis. Rheumatology. 2002;41:658–65. p

PubMed  Article  Google Scholar 

Büttner R, Wobser H, Wrede C, Schäffler A, Schölmerich J, Büchler C, et al. Supplementation of folic acid improves insulin resistance in the high fat fed rat. Exp Clin Endocrinol Diab. 2007;115:P02–060.

Article  Google Scholar 

Solini A, Santini E, Ferrannini E. Effect of short-term folic acid supplementation on insulin sensitivity and inflammatory markers in overweight subjects. Int J Obes. 2006;30:1197–202.

CAS  Article  Google Scholar 

Najib S, Sanchez-Margalet V. Homocysteine thiolactone inhibits insulin signaling, and glutathione has a protective effect. J Mol Endocrinol. 2001;27:85–91.

CAS  PubMed  Article  Google Scholar 

Song Y, Cook NR, Albert CM, Van Denburgh M, Manson JE. Effect of homocysteine-lowering treatment with folic Acid and B vitamins on risk of type 2 diabetes in women: a randomized, controlled trial. Diabetes. 2009;58:1921–8.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Lind MV, Lauritzen L, Kristensen M, Ross AB, Eriksen JN. Effect of folate supplementation on insulin sensitivity and type 2 diabetes: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2019;109:29–42.

PubMed  Article  Google Scholar 

Chiarelli F, Pomilio M, Mohn A, Tumini S, Vanelli M, Morgese G, et al. Homocysteine levels during fasting and after methionine loading in adolescents with diabetic retinopathy and nephropathy. J Pediatr. 2000;137:386–92.

CAS