The anesthetic management of a type-2 neurofibromatosis patient with a difficult airway is quite challenging. Such a situation tests the limits of the anesthesiologist's preparedness in maintaining the balance of the cerebral protection strategies and securing the airway. The anticipated challenges include managing the airway, controlling the raised intracranial pressure, and maintaining stable hemodynamics in anticipation of the expected blood loss. This article focuses on the preoperative airway evaluation and intraoperative preparedness in case of a patient with type-2 neurofibromatosis scheduled for craniotomy and excision of intracranial meningioma.