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Microbiota: Systematic Review and Meta-Analysis
Yue L.a· Zhang R.b,c· Chen S.a· Duan G.aaDepartment of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, China
bThe First Affiliated Hospital and International School of Public Health and One Health, Hainan Medical University, Haikou, China
cMolecular Epidemiology Group, College of Public Health, Zhengzhou University, Zhengzhou, China
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Article / Publication Details
Received: July 03, 2021
Accepted: March 14, 2022
Published online: April 04, 2022
Number of Print Pages: 14
Number of Figures: 5
Number of Tables: 4
ISSN: 0257-2753 (Print)
eISSN: 1421-9875 (Online)
For additional information: https://www.karger.com/DDI
AbstractBackground: Helicobacter pylori (H. pylori) may be a risk factor for hypertension, but the reported studies have given conflicting results. This study aimed to explore the association between H. pylori infection and hypertension risk and blood pressure. Method: PubMed, Embase, Web of Science, CNKI, Weipu, and Wanfang databases were searched for articles published up to June 2, 2021. Dual-selection and data abstraction were conducted. Random-effect models were used to measure pooled estimates. All data were analyzed with Stata 14.0 SE (StataCorp, College Station, TX, USA). Results: A total of 55 studies with 198,750 individuals were included in the meta-analysis. Among them, 33 studies reported the relationship between H. pylori infection and the risk of hypertension, and 25 studies reported the association of H. pylori infection with systolic blood pressure (SBP) and diastolic blood pressure (DBP). Three studies reported both of the above. Meta-analysis showed that H. pylori infection increased the risk of hypertension by 32% (odd ratio: 1.32, 95% CI: 1.15–1.52). Compared with non-H. pylori-infection individuals, the subjects with H. pylori infection had elevated levels of SBP (WMD: 1.86, 95% CI: 1.21–2.50) and DBP (WMD: 1.12, 95% CI: 0.81–1.43). Conclusion: This meta-analysis suggested that H. pylori infection increased the risk of hypertension. This may provide a new strategy for hypertension prevention. However, the association between H. pylori infection and hypertension needs to be confirmed in further prospective cohort studies.
© 2022 S. Karger AG, Basel
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Received: July 03, 2021
Accepted: March 14, 2022
Published online: April 04, 2022
Number of Print Pages: 14
Number of Figures: 5
Number of Tables: 4
ISSN: 0257-2753 (Print)
eISSN: 1421-9875 (Online)
For additional information: https://www.karger.com/DDI
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