Integrated analysis of tRNA-derived small RNAs in proliferative human aortic smooth muscle cells

Collaborators GBDCoD. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390:1151–210.

Article  Google Scholar 

Owens GK, Kumar MS, Wamhoff BR. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev. 2004;84:767–801.

CAS  PubMed  Article  Google Scholar 

Sun B, Cao Q, Meng M, Wang X. MicroRNA-186-5p serves as a diagnostic biomarker in atherosclerosis and regulates vascular smooth muscle cell proliferation and migration. Cell Mol Biol Lett. 2020;25:27.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Han Y, Liu Y, Yang C, Gao C, Guo X, Cheng J. LncRNA CASC2 inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation and migration by regulating the miR-222/ING5 axis. Cell Mol Biol Lett. 2020;25:21.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Jeong K, Kim JH, Murphy JM, Park H, Kim SJ, Rodriguez YAR, Kong H, Choi C, Guan JL, Taylor JM, Lincoln TM, Gerthoffer WT, Kim JS, Ahn EE, Schlaepfer DD, Lim SS. Nuclear focal adhesion kinase controls vascular smooth muscle cell proliferation and neointimal hyperplasia through GATA4-mediated cyclin D1 transcription. Circ Res. 2019;125:152–66.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Matsuoka T, Wada J, Hashimoto I, Zhang Y, Eguchi J, Ogawa N, Shikata K, Kanwar YS, Makino H. Gene delivery of Tim44 reduces mitochondrial superoxide production and ameliorates neointimal proliferation of injured carotid artery in diabetic rats. Diabetes. 2005;54:2882–90.

CAS  PubMed  Article  Google Scholar 

Lee YS, Shibata Y, Malhotra A, Dutta A. A novel class of small RNAs: tRNA-derived RNA fragments (tRFs). Genes Dev. 2009;23:2639–49.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Zhu XL, Li T, Cao Y, Yao QP, Liu X, Li Y, Guan YY, Deng JJ, Jiang R, Jiang J. tRNA-derived fragments tRF(GlnCTG) induced by arterial injury promote vascular smooth muscle cell proliferation. Mol Ther Nucleic Acids. 2021;23:603–13.

CAS  PubMed  Article  Google Scholar 

He X, Yang Y, Wang Q, Wang J, Li S, Li C, Zong T, Li X, Zhang Y, Zou Y, Yu T. Expression profiles and potential roles of transfer RNA-derived small RNAs in atherosclerosis. J Cell Mol Med. 2021;25:7052–65.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Zong T, Yang Y, Lin X, Jiang S, Zhao H, Liu M, Meng Y, Li Y, Zhao L, Tang G, Gong K, Wang Z, Yu T. 5’-tiRNA-Cys-GCA regulates VSMC proliferation and phenotypic transition by targeting STAT4 in aortic dissection. Mol Ther Nucleic Acids. 2021;26:295–306.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Kumar P, Mudunuri SB, Anaya J, Dutta A. tRFdb: a database for transfer RNA fragments. Nucleic Acids Res. 2015;43:D141-145.

CAS  PubMed  Article  Google Scholar 

Kruger J, Rehmsmeier M. RNAhybrid: microRNA target prediction easy, fast and flexible. Nucleic Acids Res. 2006;34:W451-454.

PubMed  PubMed Central  Article  CAS  Google Scholar 

John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets. PLoS Biol. 2004;2:e363.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Lin JJ, Chen W, Gong M, Xu X, Du MY, Wang SF, Yang LY, Wang Y, Liu KX, Kong P, Li B, Liu K, Li YM, Dong LH, Sun SG. Expression and functional analysis of lncRNAs involved in platelet-derived growth factor-BB-induced proliferation of human aortic smooth muscle cells. Front Cardiovasc Med. 2021;8:702718.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Agarwal V, Bell GW, Nam JW, Bartel DP. Predicting effective microRNA target sites in mammalian mRNAs. Elife. 2015;4:e05005.

PubMed Central  Article  Google Scholar 

da Huang W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009;4:44–57.

CAS  Article  Google Scholar 

Kumar P, Anaya J, Mudunuri SB, Dutta A. Meta-analysis of tRNA derived RNA fragments reveals that they are evolutionarily conserved and associate with AGO proteins to recognize specific RNA targets. BMC Biol. 2014;12:78.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Li H, Fan J, Zhao Y, Zhang X, Dai B, Zhan J, Yin Z, Nie X, Fu XD, Chen C, Wang DW. Nuclear miR-320 mediates diabetes-induced cardiac dysfunction by activating transcription of fatty acid metabolic genes to cause lipotoxicity in the heart. Circ Res. 2019;125:1106–20.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Di Mauro V, Crasto S, Colombo FS, Di Pasquale E, Catalucci D. Wnt signalling mediates miR-133a nuclear re-localization for the transcriptional control of Dnmt3b in cardiac cells. Sci Rep. 2019;9:9320.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Maute RL, Schneider C, Sumazin P, Holmes A, Califano A, Basso K, Dalla-Favera R. tRNA-derived microRNA modulates proliferation and the DNA damage response and is down-regulated in B cell lymphoma. Proc Natl Acad Sci U S A. 2013;110:1404–9.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Muller PA, Vousden KH. Mutant p53 in cancer: new functions and therapeutic opportunities. Cancer Cell. 2014;25:304–17.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Zhang R, Han M, Zheng B, Li YJ, Shu YN, Wen JK. Kruppel-like factor 4 interacts with p300 to activate mitofusin 2 gene expression induced by all-trans retinoic acid in VSMCs. Acta Pharmacol Sin. 2010;31:1293–302.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Chen KH, Guo X, Ma D, Guo Y, Li Q, Yang D, Li P, Qiu X, Wen S, Xiao RP, Tang J. Dysregulation of HSG triggers vascular proliferative disorders. Nat Cell Biol. 2004;6:872–83.

CAS  PubMed  Article  Google Scholar 

Lu Z, Li S, Zhao S, Fa X. Upregulated miR-17 regulates hypoxia-mediated human pulmonary artery smooth muscle cell proliferation and apoptosis by targeting mitofusin 2. Med Sci Monit. 2016;22:3301–8.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Feng S, Gao L, Zhang D, Tian X, Kong L, Shi H, Wu L, Huang Z, Du B, Liang C, Zhang Y, Yao R. MiR-93 regulates vascular smooth muscle cell proliferation, and neointimal formation through targeting Mfn2. Int J Biol Sci. 2019;15:2615–26.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Xu L, Hao H, Hao Y, Wei G, Li G, Ma P, Xu L, Ding N, Ma S, Chen AF, Jiang Y. Aberrant MFN2 transcription facilitates homocysteine-induced VSMCs proliferation via the increased binding of c-Myc to DNMT1 in atherosclerosis. J Cell Mol Med. 2019;23:4611–26.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Li F, Kaczor-Urbanowicz KE, Sun J, Majem B, Lo HC, Kim Y, Koyano K, Rao SL, Kang SY, Kim SM, Kim KM, Kim S, Chia D, Elashoff D, Grogan TR, Xiao X, Wong DTW. Characterization of human salivary extracellular RNA by next-generation sequencing. Clin Chem. 2018;64:1085–95.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Godoy PM, Bhakta NR, Barczak AJ, Cakmak H, Fisher S, MacKenzie TC, Patel T, Price RW, Smith JF, Woodruff PG, Erle DJ. Large differences in small RNA composition between human biofluids. Cell Rep. 2018;25:1346–58.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Krishna S, Raghavan S, DasGupta R, Palakodeti D. tRNA-derived fragments (tRFs): establishing their turf in post-transcriptional gene regulation. Cell Mol Life Sci. 2021. https://doi.org/10.1007/s00018-020-03720-7.

Article  PubMed  Google Scholar 

Guzzi N, Ciesla M, Ngoc PCT, Lang S, Arora S, Dimitriou M, Pimkova K, Sommarin MNE, Munita R, Lubas M, Lim Y, Okuyama K, Soneji S, Karlsson G, Hansson J, Jonsson G, Lund AH, Sigvardsson M, Hellstrom-Lindberg E, Hsieh AC, Bellodi C. Pseudouridylation of tRNA-derived fragments steers translational control in stem cells. Cell. 2018;173:1204-1216.e1226.

CAS  PubMed  Article  Google Scholar 

Kim HK, Xu J, Chu K, Park H, Jang H, Li P, Valdmanis PN, Zhang QC, Kay MA. A tRNA-derived small rna regulates ribosomal protein S28 protein levels after translation initiation in humans and mice. Cell Rep. 2019;29:3816-24.e3814.

Google Scholar 

Martinez G, Choudury SG, Slotkin RK. tRNA-derived small RNAs target transposable element transcripts. Nucleic Acids Res. 2017;45:5142–52.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Huang B, Yang H, Cheng X, Wang D, Fu S, Shen W, Zhang Q, Zhang L, Xue Z, Li Y, Da Y, Yang Q, Li Z, Liu L, Qiao L, Kong Y, Yao Z, Zhao P, Li M, Zhang R. tRF/miR-1280 suppresses stem cell-like cells and metastasis in colorectal cancer. Cancer Res. 2017;77:3194–206.

CAS  PubMed  Article  Google Scholar 

Goodarzi H, Liu X, Nguyen HC, Zhang S, Fish L, Tavazoie SF. Endogenous tRNA-derived fragments suppress breast cancer progression via YBX1 displacement. Cell. 2015;161:790–802.

CAS  PubMed  PubMed Central  Article  Google Schol

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