Feasibility and Research Insights From a Randomized Controlled Trial for Recurrent Urinary Tract Infection Prevention in Postmenopausal Women Using Vaginal Estrogen Therapy

From the ∗Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics, Gynecology, and Women’s Health, University of Louisville School of Medicine, Louisville, KY

†Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, Washington University School of Medicine

‡Division of Infectious Diseases, Department of Internal Medicine

§Division of Clinical Research, Department of Obstetrics and Gynecology, Washington University School of Medicine

∥Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, MO.

The authors have declared they have no conflicts of interest.

Correspondence: Stacy Lenger, MD. E-mail: [email protected].

M.J.D. was supported by the Foundation for Barnes-Jewish Hospital, National Center for Advancing Translational Sciences (NCATS) KL2TR002346, and the National Institute for Dental and Craniofacial Research (NIDCR) K23DE029514. S.S. was supported by the Foundation for Barnes-Jewish Hospital, NCATS (UL1 TR002345), and the Alvin J. Siteman Cancer Center (P30 CA091842). Research reported in this publication was supported by the NCATS (UL1 TR002345). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or other funding sources. These funding sources were not involved in the research, collection, analysis, data interpretation, manuscript writing, or decision to submit the article for publication. The study itself was funded by divisional funding.

An abstract of an initial analysis of a small subset of the data presented in this article (the portion related to referral numbers for urinary tract infection [UTI] and number of patients with culture-proven recurrent UTI) was presented as a poster at the International Continence Society (ICS) 49th Annual Scientific Meeting Gothenburg, Sweden, September 3–6, 2019. The ICS abstract data have not been published in manuscript form. The data in this manuscript include an additional year of evaluated patients, so the data are not identical to the ICS abstract.

J.L.L. and S.S. are co-senior authors on this article.

Clinical Trial Registration: ClinicalTrials.gov Identifier: NCT03395288

URL of registration site: https://clinicaltrials.gov/ct2/show/study/NCT03395288

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s Web site (www.fpmrs.net).

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