Wan, Y., H. Wu, Y. Li, Z. Xu, J. Yang, C. Liu, Y. He, M. Wang, X. Wu, and Y. Zhang. 2020. viaTSG-6 Inhibits Oxidative Stress and Induces M2 Polarization of Hepatic Macrophages in Mice With Alcoholic Hepatitis Suppression of STAT3 Activation. Frontiers in pharmacology 11: 10.

CAS  Article  Google Scholar 

Xiang, X., S. Hwang, D. Feng, V. Shah, and B. Gao. 2020. Interleukin-22 in alcoholic hepatitis and beyond. Hepatology international 14: 667–676.

Article  Google Scholar 

Takeuchi, M., P. Vidigal, M. Guerra, M. Hundt, M. Robert, M. Olave-Martinez, S. Aoki, T. Khamphaya, R. Kersten, E. Kruglov, et al. 2021. Neutrophils interact with cholangiocytes to cause cholestatic changes in alcoholic hepatitis. Gut 70: 342–356.

CAS  PubMed  Google Scholar 

Gala, K., and V. Vatsalya. 2020. Emerging noninvasive biomarkers, and medical management strategies for alcoholic hepatitis: present understanding and scope. Cells 9.

Waleed, M., M. Abdallah, Y. Kuo, J. Arab, R. Wong, and A. Singal. 2020. Higher Frequency of Hospital-Acquired Infections but Similar In-Hospital Mortality Among Admissions With Alcoholic Hepatitis at Academic vs. Non-academic Centers. Frontiers in physiology 11: 594138.

Bieghs, V., and C. Trautwein. 2013. The innate immune response during liver inflammation and metabolic disease. Trends in immunology 34: 446–452.

CAS  Article  Google Scholar 

Han, Y., B. Glueck, D. Shapiro, A. Miller, S. Roychowdhury, and G. Cresci. 2020. Dietary Synbiotic Supplementation Protects Barrier Integrity of Hepatocytes and Liver Sinusoidal Endothelium in a Mouse Model of Chronic-Binge Ethanol Exposure. Nutrients 12.

Li, Y., Y. Zeng, Q. Huang, S. Wen, Y. Wei, Y. Chen, X. Zhang, F. Bai, Z. Lu, J. Wei, X. Lin. 2019. Helenalin from Centipeda minima ameliorates acute hepatic injury by protecting mitochondria function, activating Nrf2 pathway and inhibiting NF-κB activation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 119: 109435.

Zheng, H., J. Wu, H. Huang, C. Meng, W. Li, T. Wei, and Z. Su. 2019. Metabolomics analysis of the protective effect of rubusoside on palmitic acid-induced lipotoxicity in INS-1 cells using UPLC-Q/TOF MS. Molecular omics 15: 222–232.

CAS  Article  Google Scholar 

Rachakonda, V., C. Gabbert, A. Raina, L. Bell, S. Cooper, S. Malik, J. Behari. 2014. Serum metabolomic profiling in acute alcoholic hepatitis identifies multiple dysregulated pathways. PloS one 9: e113860.

Michelena, J., C. Alonso, I. Martínez-Arranz, J. Altamirano, R. Mayo, P. Sancho-Bru, R. Bataller, P. Ginès, A. Castro, and J. Caballería. 2019. Metabolomics Discloses a New Non-invasive Method for the Diagnosis and Prognosis of Patients with Alcoholic Hepatitis. Annals of hepatology 18: 144–154.

CAS  Article  Google Scholar 

Wang, D., L. Lao, X. Pang, Q. Qiao, L. Pang, Z. Feng, F. Bai, X. Sun, X. Lin, and J. Wei. 2018. Asiatic acid from Potentilla chinensis alleviates non-alcoholic fatty liver by regulating endoplasmic reticulum stress and lipid metabolism. International Immunopharmacology 65: 256–267.

CAS  Article  Google Scholar 

Federico, A., M. Dallio, and C. Loguercio. 2017. Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years. Molecules (Basel, Switzerland) 22.

Wei, J., Q. Huang, R. Huang, Y. Chen, S. Lv, L. Wei, C. Liang, S. Liang, L. Zhuo, and X. Lin. 2013. Asiatic acid from Potentilla chinensis attenuate ethanol-induced hepatic injury via suppression of oxidative stress and Kupffer cell activation. Biological pharmaceutical bulletin 36: 1980–1989.

CAS  Article  Google Scholar 

Feng, Z., L. Pang, S. Chen, X. Pang, Y. Huang, Q. Qiao, Y. Wang, S. Vonglorkham, Q. Huang, X. Lin, and J. Wei. Didymin ameliorates dexamethasone-induced non-alcoholic fatty liver disease by inhibiting TLR4/NF-κB and PI3K/Akt pathways in C57BL/6J mice. International immunopharmacology 88: 107003.

Pang, X., Q. Qiao, S. Vonglorkham, Z. Feng, L. Pang, S. Chen, D. Wang, L. Lao, X. Lin, and J. Wei. 2020. Asiatic acid ameliorates acute hepatic injury by reducing endoplasmic reticulum stress and triggering hepatocyte autophagy. Biomed Pharmacother 129: 110375.

Xiao, W., R.S. Wang, D.E. Handy, and J. Loscalzo. 2018. NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism. Antioxidants & Redox Signaling 28: 251–272.

CAS  Article  Google Scholar 

Piszczatowska, K., D. Przybylska, E. Sikora, and G. Mosieniak. Inhibition of NADPH Oxidases Activity by Diphenyleneiodonium Chloride as a Mechanism of Senescence Induction in Human Cancer Cells. Antioxidants 9.

Zhao, X., L. Gong, C. Wang, M. Liu, N. Hu, X. Dai, C. Peng, and Y. Li. 2021. Quercetin mitigates ethanol-induced hepatic steatosis in zebrafish via P2X7R-mediated PI3K/ Keap1/Nrf2 signaling pathway. J Ethnopharmacol 268: 113569.

Sehrawat, T., M. Liu, and V. Shah. 2020. The knowns and unknowns of treatment for alcoholic hepatitis. The lancet Gastroenterology hepatology international 5: 494–506.

Article  Google Scholar 

Massey, V., A. Parrish, J. Argemi, M. Moreno, A. Mello, M. García-Rocha, J. Altamirano, G. Odena, L. Dubuquoy, A. Louvet, et al. 2021. Integrated Multiomics Reveals Glucose Use Reprogramming and Identifies a Novel Hexokinase in Alcoholic Hepatitis. Gastroenterology 160: 1725-1740.e1722.

CAS  Article  Google Scholar 

Ginting, C., I. Lister, E. Girsang, W. Widowati, D. Yusepany, A. Azizah, and H. Kusuma. 2021. Piper crocatumHepatotoxicity prevention in Acetaminophen-induced HepG2 cells by red betel ( Ruiz and Pav) extract from Indonesia via antioxidant, anti-inflammatory, and anti-necrotic. Heliyon 7: e05620.

Wei, X., H. Wang, X. Sun, X. Huang, W. Xu, Y. Liang, L. Liu, S. Mo, X. Lin, and J. Lin. 2020. 4-hydroxy-2(3H)-benzoxazolone alleviates acetaminophen-induced hepatic injury by inhibiting NF-κB and activating Nrf2/HO-1 signaling pathways. American journal of translational research 12: 2169–2180.

CAS  PubMed  PubMed Central  Google Scholar 

Sung, C.K., S.M. Kim, C.J. Oh, S.A. Yang, B.H. Han, and E.K. Mo. 2012. Taraxerone enhances alcohol oxidation via increases of alcohol dehyderogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activities and gene expressions. Food Chemical Toxicology 50: 2508–2514.

CAS  Article  Google Scholar 

Yoo, Y., E. Jung, H. Kang, I. Choi, K. Choi, and E. Jeung. 2011. The sap of Acer okamotoanum decreases serum alcohol levels after acute ethanol ingestion in rats. International Journal of Molecular Medicine 28: 489–495.

PubMed  Google Scholar 

Yu, J., H. Zhu, M. Kindy, and S. Taheri. Cytochrome P450 CYP2E1 Suppression Ameliorates Cerebral Ischemia Reperfusion Injury. Antioxidants 10.

Hsu, M., S. Koike, A. Mello, L. Nagy, and F. Haj. 2020. Hepatic protein-tyrosine phosphatase 1B disruption and pharmacological inhibition attenuate ethanol-induced oxidative stress and ameliorate alcoholic liver disease in mice. Redox biology 36: 101658.

Chuang, C., C. Tsai, E. Lin, C. Huang, Y. Lin, C. Lan, and C. Huang. 2016. Heat-Killed Lactobacillus salivarius and Lactobacillus johnsonii Reduce Liver Injury Induced by Alcohol In Vitro and In Vivo. Molecules 21.

Robinson, K.E., and V.H. Shah. 2020. Pathogenesis and pathways: Nonalcoholic fatty liver disease & alcoholic liver disease. Translational Gastroenterology & Hepatology 5: 49–49.

Article  Google Scholar 

Shi, X., X. Jiang, B. Yuan, T. Liu, Y. Tang, Y. Che, Y. Shi, and Q. Ai. 2019. LINC01093Upregulation Protects against Alcoholic Hepatitis through Inhibition of NF-κB Signaling Pathway. Molecular Therapy-Nucleic Acids 17: 791–803.

CAS  Article  Google Scholar 

Sun, X., X. Huang, X. Zhu, L. Liu, S. Mo, H. Wang, X. Wei, S. Lu, F. Bai, and D. Wang. et al. HBOA ameliorates CCl-incuded liver fibrosis through inhibiting TGF-β1/Smads, NF-κB and ERK signaling pathways. Biomed Pharmacother 115: 108901.

Li, P., D. Bing, X. Wang, J. Chen, Z. Du, Y. Sun, F. Qi, and H. Chu. New Target of Oxidative Stress Regulation in Cochleae: Alternative Splicing of the p62/Sqstm1 Gene. Journal of molecular neuroscience : MN 2022.

Xu, L., B. Zhao, S. Sun, S. Yu, Y. Wang, R. Ji, Z. Yang, L. Ma, Y. Yao, Y. Chen, et al. 2020. High-dose vitamin C alleviates pancreatic injury via the NRF2/NQO1/HO-1 pathway in a rat model of severe acute pancreatitis. Annals of translational medicine 8: 852.

Article  Google Scholar 

Wang, K., X. Zheng, Z. Pan, W. Yao, X. Gao, X. Wang, and X. Ding. 2020. Icariin Prevents Extracellular Matrix Accumulation and Ameliorates Experimental Diabetic Kidney Disease by Inhibiting Oxidative Stress via GPER Mediated p62-Dependent Keap1 Degradation and Nrf2 Activation. Frontiers in cell developmental biology 8: 559.

CAS  Article  Google Scholar 

Dkhil, M., A. Abdel Moneim, T. Hafez, M. Mubaraki, W. Mohamed, F. Thagfan, S. and Al-Quraishy. 2019. Myristica fragrans Kernels Prevent Paracetamol-Induced Hepatotoxicity by Inducing Anti-Apoptotic Genes and Nrf2/HO-1 Pathway. Int J Mol Sci 20.

Zhuang, L., W. Ding, Q. Zhang, W. Ding, X. Xu, X. Yu, and D. Xi. 2021. TGR5 Attenuated Liver Ischemia-Reperfusion Injury by Activating the Keap1-Nrf2 Signaling Pathway in Mice. Inflammation 44: 859–872.

CAS  Article  Google Scholar 

Zhou, C., H. Jia, Y. Liu, M. Yu, X. Chang, Y. Ba, and Z. Zou. 2016. Metabolism of glycerophospholipid, bile acid and retinol is correlated with the early outcomes of autoimmune hepatitis. Molecular bioSystems 12: 1574–1585.

CAS  Article  Google Scholar 

Miura, H., H. Mizuguchi, M. Amano-Iwashita, R. Maeda-Kogure, A. Negishi, A. Sakai, T. Toyama, H. Kawai, A. Mitsumoto, and N. Kudo. 2021. Clofibric acid increases molecular species of phosphatidylethanolamine containing arachidonic acid for biogenesis of peroxisomal membranes in peroxisome proliferation in the liver. Biochimica et biophysica acta Molecular and cell biology of lipids 1866: 158963.

Hänninen, S., P. Somerharju, and M. Hermansson. Metabolic Heavy Isotope Labeling to Study Glycerophospholipid Homeostasis of Cultured Cells. Bio-protocol 7: e2268.

Lenoir, G., J. D'Ambrosio, T. Dieudonné, A. Čopič. 2021. Transport Pathways That Contribute to the Cellular Distribution of Phosphatidylserine. Frontiers in cell and developmental biology 9: 737907.