Retard or exacerbate: Role of Long non-coding RNA growth arrest-specific 5 in the fibrosis

lncRNA Gas5

long non-coding RNA growth arrest-specific 5

CKD

chronic kidney disease

5’ TOP

5’-terminal oligo-pyrimidine

ceRNAs

competing endogenous RNAs

snoRNAs

small nucleolar RNAs

NMD

nonsense-mediated RNA decay

TGF-β

Transforming Growth Factor β

UPF1

Up-frameshift protein 1

Smad

decapentaplegic family member

eIF2α

α subunit of eukaryotic initiation factor 2

ATF4

activating transcription factor 4

CHOP

C/EBP homologous protein

E2F1

E2F Transcription Factor 1

mTOR

Mammalian target of rapamycin

SRSF4

Serine/arginine-rich splicing factor 4

GR

glucocorticoid receptor

rSBEs

RNA Smad-binding elements

eIF4E

Eukaryotic Translation Initiation Factor 4E

mTORC1/2

Mammalian target of rapamycin complex 1/2

PI3K/AKT/mTOR

Phosphatidylinositol 3-Kinase/Protein Kinase B/Mechanistic Target of the Rapamycin

Yap

yes-associated protein

TAZ

transcriptional coactivator with PDZ-binding motif

UUO-

unilateral ureteral obstruction-

GRE

glucocorticoid response element

cIAP2

cellular inhibitor of apoptosis 2

SGK1

serum and glucocorticoid-regulated kinase1

NF-κB

nuclear factor kappa B

HCC

hepatocellular carcinoma

NAFLD

nonalcoholic fatty liver disease

HSCs

hepatic stellate cells

NASH

nonalcoholic steatohepatitis

PTEN

phosphatase and tensin homolog

p-PI3K

phosphoinositide 3 kinase

α-SMA

alpha-smooth muscle actin

Col1A1

Collagen-type I alpha 1 chain

TLR10

toll-like receptor 10

CDK2

cyclin-dependent kinase 2

PDCD4

programmable cell death 4

MMP9

matrix metalloproteinase9

HepG2 cells

hepatocellular carcinoma cells

UUO

unilateral ureteral obstruction

STZ/HFD

streptozotocin/high-fat diet feeding

smORFs

small open reading frames

JNK

c-Jun N-terminal kinase

BNIP3

Bcl-2 Nineteen kilodalton Interacting Protein 3

Creb5

cAMP response element binding 5

MMPs

matrix metalloproteinases

H3K27

histone H3 lysine 27

H3K27me3

trimethylation of histone H3 lysine 27

PRC2

polycomb repressive complex 2

VSMCs

vascular smooth muscle cells

CAD

coronary artery disease

DCM

Diabetic cardiomyopathy

PBMCs

peripheral blood mononuclear cells

TP53INP1

tumor protein 53-induced nuclear protein 1

留言 (0)

沒有登入
gif