Skin Pharmacology and Physiology
Frank L.A. · Gazzi R.P. ·
Pohlmann A.R. · Guterres S.S. · Contri R.V.
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Article / Publication Details
Abstract
Introduction: Sunscreens are substances applied on the skin surface to protect the skin from the harmful effects of UV light. Nanoparticles can increase the retention time of the sunscreen on the skin surface and its efficacy, by acting as physical barriers. The present investigation aimed to prepare and characterize benzophenone-3-loaded lipid core nanocapsules coated with chitosan (CH-LNC) and, after obtaining a suitable semisolid formulation for skin application, to evaluate the influence of the nanocapsules chitosan-coating on the skin adhesion and photoprotective effect of the sunscreen. Methods: CH-LNC were obtained by the interfacial deposition of pre-formed polymer. The semisolid formulation was obtained using hydroxyethyl cellulose as gel-forming polymer. Skin adhesion experiments were performed by keeping skin membranes with formulation under water at 32oC for up to 60 minutes. Photoprotective effect was analyzed by the capacity of the formulations to protect a photo unstable substance (resveratrol) from degradation under UV light. Results: CH-LNC presented size of around 150nm, with low polydispersity, positive zeta potential, due to chitosan, and benzophenone-3 encapsulation efficiency of close to 100% (3mg/mL). The proposed gel presented suitable consistence and pH for skin application. Although coated and uncoated LNC increased benzonphenone-3 skin adhesion after 10 minutes of water immersion, only the nanoparticles coated with chitosan were able to do so after 60 minutes. CH-LNC increased the photoprotection of the sunscreen under UVA and UVB light after 60 minutes of exposure, probably due to the bioadhesion and film-forming properties of chitosan. Conclusion: The chitosan coating of benzophenone-3-loaded LNC increased the skin adhesion and the photoprotective effect of the sunscreen.
S. Karger AG, Basel
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