Collaborators GBDO. health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med. 2017;377(1):13–27.

Article  Google Scholar 

Damsgaard CT, Michaelsen KF, Molbo D, Mortensen EL, Sørensen T. Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants. Lancet. 2016;387(10026):1377.

Article  Google Scholar 

Rosen ED, Spiegelman BM. Adipocytes as regulators of energy balance and glucose homeostasis. Nature. 2006;444(7121):847–53.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Rosen ED, Spiegelman BM. What we talk about when we talk about fat. Cell. 2014;156(1–2):20–44.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Lancha A, Fruhbeck G, Gomez-Ambrosi J. Peripheral signalling involved in energy homeostasis control. Nutr Res Rev. 2012;25(2):223–48.

CAS  PubMed  Article  Google Scholar 

Sidossis L, Kajimura S. Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis. J Clin Invest. 2015;125(2):478–86.

PubMed  PubMed Central  Article  Google Scholar 

Wu J, Bostrom P, Sparks LM, Ye L, Choi JH, Giang AH, et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell. 2012;150(2):366–76.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Ma XR, Xu LY, Alberobello AT, Gavrilova O, Bagattin A, Skarulis M, et al. Celastrol protects against obesity and metabolic dysfunction through activation of a HSF1-PGC1alpha transcriptional axis. Cell Metab. 2015;22(4):695–708.

CAS  PubMed  Article  Google Scholar 

Zhang ZG, Zhang HZ, Bo L, Meng XJ, Wang JQ, Zhang YF, et al. Berberine activates thermogenesis in white and brown adipose tissue. Nat Commun. 2014;5(5):5493.

CAS  PubMed  Article  Google Scholar 

Whiting S, Derbyshire E, Tiwari BK. Capsaicinoids and capsinoids. A potential role for weight management? A systematic review of the evidence. Appetite. 2012;59(2):341–8.

CAS  PubMed  Article  Google Scholar 

Xie K, He X, Chen KY, Sakao K, Hou DX. Ameliorative effects and molecular mechanisms of vine tea on western diet-induced NAFLD. Food Funct. 2020;11(7):5976–91.

CAS  PubMed  Article  Google Scholar 

Xiang JM, Lv QY, Yi F, Song YJ, Le L, Jiang BP, et al. Dietary supplementation of vine tea ameliorates glucose and lipid metabolic disorder via akt signaling pathway in diabetic rats. Molecules. 2019;24(10):1866.

CAS  PubMed Central  Article  Google Scholar 

Hou XL, Tong Q, Wang WQ, Shi CY, Xiong W, Chen J, et al. Suppression of inflammatory responses by dihydromyricetin, a flavonoid from ampelopsis grossedentata, via inhibiting the activation of NF-kappaB and MAPK signaling pathways. J Nat Prod. 2015;78(7):1689–96.

CAS  PubMed  Article  Google Scholar 

Jiang BP, Le L, Pan HM, Hu KP, Xu LJ, Xiao PJ. Dihydromyricetin ameliorates the oxidative stress response induced by methylglyoxal via the AMPK/GLUT4 signaling pathway in PC12 cells. Brain Res Bull. 2014;109:117–26.

CAS  PubMed  Article  Google Scholar 

Zhang QY, Liu J, Liu B, Xia J, Chen NP, Chen XF, et al. Dihydromyricetin promotes hepatocellular carcinoma regression via a p53 activation-dependent mechanism. Sci Rep. 2014;4(4):4628.

PubMed  PubMed Central  Google Scholar 

Zeng XL, Yang JN, Hu O, Huang J, Ran L, Chen MT, et al. Dihydromyricetin ameliorates nonalcoholic fatty liver disease by improving mitochondrial respiratory capacity and redox homeostasis through modulation of SIRT3 signaling. Antioxid Redox Signal. 2019;30(2):163–83.

CAS  PubMed  Article  Google Scholar 

He JD, Zhang JP, Dong LJ, Dang XF, Wang L, Cheng L, et al. Dihydromyricetin attenuates metabolic syndrome and improves insulin sensitivity by upregulating insulin receptor substrate-1 (Y612) tyrosine phosphorylation in db/db mice. Diabetes Metab Syndr Obes. 2019;12:2237–49.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Liu L, Zhou M, Lang HD, Zhou Y, Mi MT. Dihydromyricetin enhances glucose uptake by inhibition of MEK/ERK pathway and consequent down-regulation of phosphorylation of PPARgamma in 3T3-L1 cells. J Cell Mol Med. 2018;22(2):1247–56.

CAS  PubMed  Google Scholar 

Sun BM, Tan DG, Pan DJ, Baker MR, Liang Z, Wang ZB, et al. Dihydromyricetin imbues antiadipogenic effects on 3T3-L1 cells via direct interactions with 78-kDa glucose-regulated protein. J Nutr. 2021;151(7):1717–25.

PubMed  Article  Google Scholar 

Ju LP, Zhang XY, Deng YJ, Han J, Yang J, Chen SQ, et al. Enhanced expression of Survivin has distinct roles in adipocyte homeostasis. Cell Death Dis. 2017;8(1): e2533.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Wang JQ, Liu RX, Wang F, Hong J, Li XY, Chen MP, et al. Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch. Nat Cell Biol. 2013;15(12):1455–63.

CAS  PubMed  Article  Google Scholar 

Eguchi J, Wang X, Yu ST, Kershaw EE, Chiu PC, Dushay J, et al. Transcriptional control of adipose lipid handling by IRF4. Cell Metab. 2011;13(3):249–59.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Han HZ, Dong YD, Ma XL. Dihydromyricetin protects against gentamicin-induced ototoxicity via PGC-1alpha/SIRT3 signaling in vitro. Front Cell Dev Biol. 2020;8:702.

PubMed  PubMed Central  Article  Google Scholar 

Xue BZ, Coulter A, Rim JS, Koza RA, Kozak LP. Transcriptional synergy and the regulation of Ucp1 during brown adipocyte induction in white fat depots. Mol Cell Biol. 2005;25(18):8311–22.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Kong XX, Banks A, Liu TM, Kazak L, Rao RR, Cohen P, et al. IRF4 is a key thermogenic transcriptional partner of PGC-1alpha. Cell. 2014;158(1):69–83.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Shan TZ, Xiong Y, Zhang PP, Li ZG, Jiang QY, Bi PP, et al. Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3. Nat Commun. 2016;7:12205.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Mills EL, Pierce KA, Jedrychowski MP, Garrity R, Winther S, Vidoni S, et al. Accumulation of succinate controls activation of adipose tissue thermogenesis. Nature. 2018;560(7716):102–6.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Qi GH, Zhou Y, Zhang XP, Yu JQ, Li X, Cao XX, et al. Cordycepin promotes browning of white adipose tissue through an AMP-activated protein kinase (AMPK)-dependent pathway. Acta Pharm Sin B. 2019;9(1):135–43.

PubMed  Article  Google Scholar 

Liu L, Wan J, Lang HD, Si MY, Zhu JD, Zhou Y, et al. Dihydromyricetin delays the onset of hyperglycemia and ameliorates insulin resistance without excessive weight gain in Zucker diabetic fatty rats. Mol Cell Endocrinol. 2017;439(1):105–15.

CAS  PubMed  Article  Google Scholar 

Chen SH, Zhao XL, Wan J, Ran L, Qin Y, Wang XF, et al. Dihydromyricetin improves glucose and lipid metabolism and exerts anti-inflammatory effects in nonalcoholic fatty liver disease: a randomized controlled trial. Pharmacol Res. 2015;99:74–81.

CAS  PubMed  Article  Google Scholar 

Zhou QC, Chen K, Liu P, Gao YX, Zou D, Deng HL, et al. Dihydromyricetin stimulates irisin secretion partially via the PGC-1alpha pathway. Mol Cell Endocrinol. 2015;412:349–57.

CAS  PubMed  Article  Google Scholar 

Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell. 1998;92(6):829–39.

CAS  PubMed  Article  Google Scholar 

Puigserver P, Spiegelman BM. Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr Rev. 2003;24(1):78–90.

CAS  PubMed  Article  Google Scholar 

Bagattin A, Hugendubler L, Mueller E. Transcriptional coactivator PGC-1alpha promotes peroxisomal remodeling and biogenesis. Proc Natl Acad Sci U S A. 2010;107(47):20376–81.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Cantó C, Auwerx J. PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure. Curr Opin Lipidol. 2009;20(2):98–105.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Cunningham JT, Rodgers JT, Arlow DH, Vazquez F, Mootha VK, Puigserver P. mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature. 2007;450(7170):736–40.

CAS  PubMed  Article  Google Scholar 

Boutant M, Joffraud M, Kulkarni SS, Garcia-Casarrubios E, Garcia-Roves PM, Ratajczak J, et al. SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function. Mol Metab. 2015;4(2):118–31.

CAS