Tissue-specific proteasomes in generation of MHC class I peptides and CD8+ T cells

ElsevierVolume 77, August 2022, 102217Current Opinion in ImmunologyHighlights•

Thymoproteasomes and immunoproteasomes contribute to the development of CD8+ T cells.

Thymoproteasomes optimize the positive selection of CD8+ T cells in the thymic cortex.

Thymoproteasome component b5t is a thymus-specific and vertebrate-specific molecule.

Thymoproteasomes and immunoproteasomes are two types of tissue-specific proteasomes, which contribute to the production of major histocompatibility complex (MHC) class I (MHC-I)-associated peptides that are important for the development and function of CD8+ cytotoxic T cells. Thymoproteasomes are specifically expressed by cortical thymic epithelial cells and are important for MHC-I-dependent positive selection of developing thymocytes, whereas immunoproteasomes are abundant in many other cells, including hematopoietic cells and medullary thymic epithelial cells. Here we summarize the role of these two tissue-specific proteasomes, focusing on their functions in the development of CD8+ T cells in the thymus.

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Published by Elsevier Ltd.

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