Systematic Review and Meta-Analysis
Juul A.D.a,b· Falster C.a,b· Rasmussen T.R.c· Hilberg O.d· Jacobsen N.a,b· Arshad A.a· Laursen C.B.a,baDepartment of Respiratory Medicine, Odense University Hospital, Odense, Denmark
bOdense Respiratory Research Unit (ODIN), Department of Clinical Research, University of Southern Denmark, Odense, Denmark
cDepartment of Respiratory Diseases and Allergology, Aarhus University Hospital, Aarhus, Denmark
dDepartment of Medicine, Vejle Littlebelt Hospital, Vejle, Denmark
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Article / Publication DetailsFirst-Page Preview
Received: February 23, 2022
Accepted: April 11, 2022
Published online: June 07, 2022
Number of Print Pages: 9
Number of Figures: 2
Number of Tables: 3
ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)
For additional information: https://www.karger.com/RES
AbstractBackground: Lung cancer is the leading cause of cancer-related death worldwide. Early diagnosis is crucial to increased survival rates. Radial endobronchial ultrasound (rEBUS) and electromagnetic navigation bronchoscopy (ENB) have been developed for the diagnosis of small lung lesions. The aim of this systematic review was to evaluate whether the combination of rEBUS and ENB is superior to ENB alone. Method: A systematic search was performed using MEDLINE, Embase, and Cochrane Library databases on “ENB,” and conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The project was registered with PROSPERO, number CRD42020214682. Results: In total, 2,092 studies were identified through a literature search. Five studies were included in the final review. One study found that the addition of rEBUS increased diagnostic yield, while another concluded the converse. Three studies did not have significant results. Meta-analysis was not feasible due to heterogeneity and the small number of studies. Conclusion: As the current evidence on the topic is sparse and heterogeneous, it is not possible to conclude whether the addition of rEBUS to ENB has a significant impact on diagnostic yield. Further studies are needed to illuminate this question in order to ensure optimal choice of endoscopic technique as well as used time and resources. The project received funding from the Region of Southern Denmark’s PhD fund.
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Received: February 23, 2022
Accepted: April 11, 2022
Published online: June 07, 2022
Number of Print Pages: 9
Number of Figures: 2
Number of Tables: 3
ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)
For additional information: https://www.karger.com/RES
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