Mitochondrial metabolism mediated macrophage polarization in chronic lung diseases

COPD

chronic obstructive pulmonary disease

IPF

idiopathic pulmonary fibrosis

OXPHOS

oxidative phosphorylation

ROS

reactive oxygen species

TNF-α

tumour necrosis factor α

MCP-1

monocyte chemoattractant protein-1

iNOS

nitric oxide synthase

NF-κB

nuclear factor kappa-light-chain enhancer of B-cell

IRF

interferon regulatory factor

STAT

signal transducers and activators of transcription

SOCS

suppressor of cytokine signalling

MAPK

mitogen-activated protein kinase

PAR2

protease-activated receptor 2

FOXO1

forkhead box protein O1

PPAR

peroxisome proliferator-activated receptor

MCTR1

maresin conjugates in tissue regeneration 1

TGF

transforming growth factor

VEGF

vascular endothelial growth factors

BALF

bronchial alveolar lavage fluid

BAMBI

bone morphogenetic protein and activin membrane-bound inhibitor

Wnt5a

Wnt family member 5a

MMP

matrix metalloproteinase

HIF1α

hypoxia-inducible factor 1-alpha

PPP

pentose phosphate pathway

NADPH

nicotinamide adenine dinucleotide phosphate

CPT2

carnitine palmitoyltransferase II

GPD2

glycerol-3-phosphate dehydrogenase 2

MIF

migration inhibitory factor

Acetyl-CoA

acetyl coenzyme A

SREBP1

sterol regulatory element-binding protein 1

TAMs

tumour-associated macrophages

GLUT1

glucose transporter 1

MCU

mitochondrial calcium uniporter

NLRP3

NOD-, LRR- and pyrin domain-containing protein 3

PGC-1α

PPAR-γ coactivator 1-alpha

CPT-1

carnitine palmitoyltransferase 1

Mycobacterium tuberculosis

Mtb

HADHA

3-hydroxyacyl-CoA dehydrogenase

GADPH

glyceraldehyde 3-phosphate dehydrogenase

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