Serum Biomarkers for Autoimmune Hepatitis Type 1: the Case for CD48 and a Review of the Literature

Moon AM, Spiritos Z, King LY et al (2020) Immunosuppression in autoimmune hepatitis: is there an end game? Am J Gastroenterol 115(4):498–501

Article  Google Scholar 

Mack CL, Adams D, Assis DN et al (2020) Diagnosis and management of autoimmune hepatitis in adults and children: 2019 Practice Guidance and Guidelines From the American Association for the Study of Liver Diseases. Hepatology 72(2):671–722. https://doi.org/10.1002/hep.31065

Article  PubMed  Google Scholar 

Bravo AA, Sheth SG, Chopra S (2001) Liver biopsy. N Engl J Med 344(7):495–500

CAS  Article  Google Scholar 

Lüth S, Herkel J, Kanzler S et al (2008) Serologic markers compared with liver biopsy for monitoring disease activity in autoimmune hepatitis. J Clin Gastroenterol 42(8):926–930

Article  Google Scholar 

Dhaliwal HK, Hoeroldt BS, Dube AK et al (2015) Long-term prognostic significance of persisting histological activity despite biochemical remission in autoimmune hepatitis. Am J Gastroenterol 110(7):993–999. https://doi.org/10.1038/ajg.2015.139

CAS  Article  PubMed  Google Scholar 

Castéra L, Foucher J, Bernard PH et al (2010) Pitfalls of liver stiffness measurement: a 5-year prospective study of 13,369 examinations. Hepatology 51(3):828–835. https://doi.org/10.1002/hep.23425

Article  PubMed  Google Scholar 

Hartl J, Denzer U, Ehlken H et al (2016) Transient elastography in autoimmune hepatitis: Timing determines the impact of inflammation and fibrosis. J Hepatol 65(4):769–775

Article  Google Scholar 

Czaja AJ (2018) Emerging therapeutic biomarkers of autoimmune hepatitis and their impact on current and future management. Expert Rev Gastroenterol Hepatol 12(6):547–564. https://doi.org/10.1080/17474124.2018.1453356

CAS  Article  PubMed  Google Scholar 

Efe C, Kav T, Aydin C et al (2014) Low serum vitamin D levels are associated with severe histological features and poor response to therapy in patients with autoimmune hepatitis. Dig Dis Sci 59(12):3035–3042. https://doi.org/10.1007/s10620-014-3267-3

CAS  Article  PubMed  Google Scholar 

Wei Y, Li Y, Yan L et al (2020) Alterations of gut microbiome in autoimmune hepatitis. Gut 69(3):569–577. https://doi.org/10.1136/gutjnl-2018-317836

CAS  Article  PubMed  Google Scholar 

Nishikawa H, Enomoto H, Iwata Y et al (2016) Clinical significance of serum Wisteria floribunda agglutinin positive Mac-2-binding protein level and high-sensitivity C-reactive protein concentration in autoimmune hepatitis. Hepatol Res 46(7):613–621. https://doi.org/10.1111/hepr.12596

CAS  Article  PubMed  Google Scholar 

Gutkowski K, Hartleb M, Kacperek-Hartleb T et al (2013) Laboratory-based scoring system for prediction of hepatic inflammatory activity in patients with autoimmune hepatitis. Liver Int 33(9):1370–1377. https://doi.org/10.1111/liv.12198

CAS  Article  PubMed  Google Scholar 

McArdel SL, Terhorst C, Sharpe AH (2016) Roles of CD48 in regulating immunity and tolerance. Clin Immunol (Orlando, Fla.) 164:10–20. https://doi.org/10.1016/j.clim.2016.01.008

Wu Y, Kuang DM, Pan WD et al (2013) Monocyte/macrophage-elicited natural killer cell dysfunction in hepatocellular carcinoma is mediated by CD48/2B4 interactions. Hepatology 57(3):1107–1116. https://doi.org/10.1002/hep.26192

CAS  Article  PubMed  Google Scholar 

Raziorrouh B, Schraut W, Gerlach T et al (2010) The immunoregulatory role of CD244 in chronic hepatitis B infection and its inhibitory potential on virus-specific CD8+ T-cell function. Hepatology 52(6):1934–1947. https://doi.org/10.1002/hep.23936

CAS  Article  PubMed  Google Scholar 

Gangwar RS, Levi-Schaffer F (2016) sCD48 is anti-inflammatory in Staphylococcus aureus Enterotoxin B-induced eosinophilic inflammation. Allergy 71(6):829–839. https://doi.org/10.1111/all.12851

CAS  Article  PubMed  Google Scholar 

Smith GM, Biggs J, Norris B et al (1997) Detection of a soluble form of the leukocyte surface antigen CD48 in plasma and its elevation in patients with lymphoid leukemias and arthritis. J Clin Immunol 17(6):502–509

CAS  Article  Google Scholar 

Gangwar RS, Minai-Fleminger Y, Seaf M et al (2017) CD48 on blood leukocytes and in serum of asthma patients varies with severity. Allergy 72(6):888–895. https://doi.org/10.1111/all.13082

Nishikawa A, Suzuki K, Kassai Y et al (2016) Identification of definitive serum biomarkers associated with disease activity in primary Sjögren’s syndrome. Arthritis Res Ther 18(1):106

Article  Google Scholar 

Hennes EM, Zeniya M, Czaja AJ et al (2008) Simplified criteria for the diagnosis of autoimmune hepatitis. Hepatology 48(1):169–176. https://doi.org/10.1002/hep.22322

Article  PubMed  Google Scholar 

Beretta-Piccoli BT, Mieli-Vergani G, Vergani D et al (2019) The challenges of primary biliary cholangitis: what is new and what needs to be done. J Autoimmun 105:102328

Chalasani N, Younossi Z, Lavine JE et al (2018) The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases. Hepatology 67(1):328–357. https://doi.org/10.1002/hep.29367

Article  PubMed  Google Scholar 

Xu Q, Sheng L, Bao H et al (2017) Evaluation of transient elastography in assessing liver fibrosis in patients with autoimmune hepatitis. J Gastroenterol Hepatol 32(3):639–644

CAS  Article  Google Scholar 

Wai CT, Greenson JK, Fontana RJ et al (2003) A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C. Hepatology 38(2):518–526

Article  Google Scholar 

Vallet-Pichard A, Mallet V, Nalpas B et al (2007) FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest. Hepatology 46(1):32–36

Scheuer PJ (1991) Classification of chronic viral hepatitis: a need for reassessment. J Hepatol 13(3):372–374

CAS  Article  Google Scholar 

You Z, Li Y, Wang Q et al (2021) The clinical significance of hepatic CD69+CD103+CD8+ resident-memory T cells in autoimmune hepatitis. Hepatology. https://doi.org/10.1002/hep.31739

Article  PubMed  Google Scholar 

Wu S, Yang Z, Zhou J et al (2019) Systematic review: diagnostic accuracy of non-invasive tests for staging liver fibrosis in autoimmune hepatitis. Hepatol Int 13(1). https://doi.org/10.1007/s12072-018-9907-5

Li Y, Yan L, Wang R et al (2021) Serum immunoglobulin G levels predict biochemical and histological remission of autoimmune hepatitis type 1: a single-center experience and literature review. Clin Rev Allergy Immunol. https://doi.org/10.1007/s12016-021-08833-w

Article  PubMed  Google Scholar 

Grønbaek H, Kreutzfeldt M, Kazankov K et al (2016) Single-centre experience of the macrophage activation marker soluble (s)CD163 associations with disease activity and treatment response in patients with autoimmune hepatitis. Aliment Pharmacol Ther 44(10):1062–1070. https://doi.org/10.1111/apt.13801

CAS  Article  PubMed  Google Scholar 

Hartl J, Ehlken H, Sebode M et al (2018) Usefulness of biochemical remission and transient elastography in monitoring disease course in autoimmune hepatitis. J Hepatol 68(4):754–763. https://doi.org/10.1016/j.jhep.2017.11.020

Article  PubMed  Google Scholar 

McArdel SL, Brown DR, Sobel RA et al (2016) Anti-CD48 monoclonal antibody attenuates experimental autoimmune encephalomyelitis by limiting the number of pathogenic CD4+ T cells. J Immunol 197(8):3038–3048

CAS  Article  Google Scholar 

Aarslev K, Dige A, Greisen SR et al (2017) Soluble programmed death-1 levels are associated with disease activity and treatment response in patients with autoimmune hepatitis. Scand J Gastroenterol 52(1):93–99. https://doi.org/10.1080/00365521.2016.1233576

CAS  Article  PubMed  Google Scholar 

Migita K, Nakamura M, Aiba Y et al (2020) Association of soluble T cell immunoglobulin domain and mucin-3 (sTIM-3) and mac-2 binding protein glycosylation isomer (M2BPGi) in patients with autoimmune hepatitis. PLoS ONE 15(12):e0238540. https://doi.org/10.1371/journal.pone.0238540

CAS  Article  PubMed  PubMed Central  Google Scholar 

Matsuoka N, Kozuru H, Koga T et al (2019) Galectin-9 in autoimmune hepatitis: correlation between serum levels of galectin-9 and M2BPGi in patients with autoimmune hepatitis. Medicine 98(35):e16924

Yokokawa J, Kanno Y, Abe K et al (2014) Anti-nucleosome autoantibodies as markers for autoimmune hepatitis and their correlation with disease activity. Hepatol Res: the official journal of the Japan Society of Hepatology 44(4):420–428. https://doi.org/10.1111/hepr.12130

CAS  Article  Google Scholar 

Calich AL, Viana VST, Cancado E et al (2013) Anti-ribosomal P protein: a novel antibody in autoimmune hepatitis. Liver Int 33(6):909–913. https://doi.org/10.1111/liv.12155

Article  PubMed  Google Scholar 

Diestelhorst J, Junge N, Jonigk D et al (2018) Baseline IL-2 and the AIH score can predict the response to standard therapy in paediatric autoimmune hepatitis. Sci Rep 8(1):419. https://doi.org/10.1038/s41598-017-18818-5

CAS  Article  PubMed  PubMed Central  Google Scholar 

Dejica D (2001) Serum soluble IL-2 receptor as a marker of lymphocyte activation in some autoimmune diseases. Effect of immunosuppressive therapy. Roumanian Arch Microbiol Immunol 60(3):183–201

Chaouali M, Azaiez MB, Tezeghdenti A et al (2020) High levels of proinflammatory cytokines IL-6, IL-8, TNF-Α, IL-23, and IFN- in Tunisian patients with type 1 autoimmune hepatitis. Eur Cytokine Netw. https://doi.org/10.1684/ecn.2020.0450

Article  PubMed  Google Scholar 

Liang M, Liwen Z, Yun Z et al (2018) Serum levels of IL-33 and correlation with IL-4, IL-17A, and hypergammaglobulinemia in patients with autoimmune hepatitis. Mediators Inflammation. https://doi.org/10.1155/2018/7964654

Durazzo M, Niro G, Premoli A et al (2009) Type 1 autoimmune hepatitis and adipokines: New markers for activity and disease progression? J Gastroenterol 44(5):476–482. https://doi.org/10.1007/s00535-009-0023-0

CAS  Article  PubMed  Google Scholar 

Ebadi M, Bhanji RA, Mazurak VC et al (2019) Severe vitamin D deficiency is a prognostic biomarker in autoimmune hepatitis. Aliment Pharmacol Ther 49(2):173–182. https://doi.org/10.1111/apt.15029

CAS  Article  PubMed  Google Scholar 

Migita K, Horai Y, Kozuru H et al (2018) Serum cytokine profiles and Mac-2 binding protein glycosylation isomer (M2BPGi) level in patients with autoimmune hepatitis. Medicine 97(50):e13450

Wang H, Yan W, Feng Z et al (2020) Plasma proteomic analysis of autoimmune hepatitis in an improved AIH mouse model. J Transl Med 18(1):3. https://doi.org/10.1186/s12967-019-02180-3

CAS  Article  PubMed  PubMed Central  Google Scholar 

Migita K, Komori A, Kozuru H et al (2015) Circulating microRNA profiles in patients with type-1 autoimmune hepatitis. PLoS ONE 10(11):e0136908. https://doi.org/10.1371/journal.pone.0136908

CAS  Article  PubMed  PubMed Central  Google Scholar 

Yao M, Wang L, Wang J et al (2022) Diagnostic value of serum Golgi protein 73 for liver inflammation in patients with autoimmune hepatitis and primary biliary cholangitis. Dis Markers. https://doi.org/10.1155/2022/4253566

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