Blood–brain barrier: emerging trends on transport models and new-age strategies for therapeutics intervention against neurological disorders

Abbott NJ, Patabendige AA, Dolman DE, Yusof SR, Begley DJ. Structure and function of the blood–brain barrier. Neurobiol Dis. 2010;37(1):13–25.

CAS  PubMed  Article  Google Scholar 

Abbott NJ. Dynamics of CNS barriers: evolution, differentiation, and modulation. Cell Mol Neurobiol. 2005;25(1):5–23.

PubMed  Article  Google Scholar 

Wilhelm I, Fazakas C, Krizbai IA. In vitro models of the blood–brain barrier. Acta Neurobiol Exp. 2011;71(1):113–28.

Google Scholar 

Furtado D, Bjornmalm M, Ayton S, Bush AI, Kempe K, Caruso F. Overcoming the blood–brain barrier: the role of nanomaterials in treating neurological diseases. Adv Mater. 2018;30(46): e1801362.

PubMed  Article  CAS  Google Scholar 

Zlokovic BV, Zlokovic BV, Apuzzo MLJ. Strategies to circumvent vascular barriers of the central nervous system. Neurosurgery. 1998;43(4):877–8.

CAS  PubMed  Article  Google Scholar 

Daneman R, Prat A. The blood–brain barrier. Cold Spring Harb Perspect Biol. 2015;7(1): a020412.

PubMed  PubMed Central  Article  Google Scholar 

Lee JP, Jeyakumar M, Gonzalez R, Takahashi H, Lee PJ, Baek RC, Clark D, Rose H, Fu G, Clarke J, et al. Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease. Nat Med. 2007;13(4):439–47.

CAS  PubMed  Article  Google Scholar 

Boese AC, Le QE, Pham D, Hamblin MH, Lee JP. Neural stem cell therapy for subacute and chronic ischemic stroke. Stem Cell Res Ther. 2018;9(1):154.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Boese AC, Hamblin MH, Lee JP. Neural stem cell therapy for neurovascular injury in Alzheimer’s disease. Exp Neurol. 2020;324: 113112.

CAS  PubMed  Article  Google Scholar 

Kaneko Y, Tajiri N, Staples M, Reyes S, Lozano D, Sanberg PR, Freeman TB, van Loveren H, Kim SU, Borlongan CV. Bone marrow-derived stem cell therapy for metastatic brain cancers. Cell Transpl. 2015;24(4):625–30.

Article  Google Scholar 

Banks WA. From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery. Nat Rev Drug Discov. 2016;15(4):275–92.

CAS  PubMed  Article  Google Scholar 

Banks WA. Drug delivery to the brain in Alzheimer’s disease: consideration of the blood–brain barrier. Adv Drug Deliv Rev. 2012;64(7):629–39.

CAS  PubMed  Article  Google Scholar 

Sweeney MD, Sagare AP, Zlokovic BV. Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders. Nat Rev Neurol. 2018;14(3):133–50.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Zlokovic BV. Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders. Nat Rev Neurosci. 2011;12(12):723–38.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Krol S, Macrez R, Docagne F, Defer G, Laurent S, Rahman M, Hajipour MJ, Kehoe PG, Mahmoudi M. Therapeutic benefits from nanoparticles: the potential significance of nanoscience in diseases with compromise to the blood brain barrier. Chem Rev. 2013;113(3):1877–903.

CAS  PubMed  Article  Google Scholar 

Zlokovic BV. The blood–brain barrier in health and chronic neurodegenerative disorders. Neuron. 2008;57(2):178–201.

CAS  PubMed  Article  Google Scholar 

Liu DZ, Ander BP, Xu H, Shen Y, Kaur P, Deng W, Sharp FR. Blood–brain barrier breakdown and repair by Src after thrombin-induced injury. Ann Neurol. 2010;67(4):526–33.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Tian W, Sawyer A, Kocaoglu FB, Kyriakides TR. Astrocyte-derived thrombospondin-2 is critical for the repair of the blood–brain barrier. Am J Pathol. 2011;179(2):860–8.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Abbott NJ. Blood–brain barrier structure and function and the challenges for CNS drug delivery. J Inherit Metab Dis. 2013;36(3):437–49.

CAS  PubMed  Article  Google Scholar 

Bernacki J, Dobrowolska A, Nierwińska K, Małecki A. Physiology and pharmacological role of the blood–brain barrier. Pharmacol Rep. 2008;60(5):600–22.

CAS  PubMed  Google Scholar 

Wolburg H, Noell S, Mack A, Wolburg-Buchholz K, Fallier-Becker P. Brain endothelial cells and the glio-vascular complex. Cell Tissue Res. 2009;335(1):75–96.

PubMed  Article  Google Scholar 

Wolburg H, Lippoldt A. Tight junctions of the blood–brain barrier: development, composition and regulation. Vascul Pharmacol. 2002;38(6):323–37.

CAS  PubMed  Article  Google Scholar 

Löscher W, Potschka H. Blood–brain barrier active efflux transporters: ATP-binding cassette gene family. NeuroRx. 2005;2(1):86–98.

PubMed  PubMed Central  Article  Google Scholar 

Mittapalli RK, Manda VK, Adkins CE, Geldenhuys WJ, Lockman PR. Exploiting nutrient transporters at the blood–brain barrier to improve brain distribution of small molecules. Ther Deliv. 2010;1(6):775–84.

CAS  PubMed  Article  Google Scholar 

Abbott NJ, Rönnbäck L, Hansson E. Astrocyte-endothelial interactions at the blood–brain barrier. Nat Rev Neurosci. 2006;7(1):41–53.

CAS  PubMed  Article  Google Scholar 

Sims DE. The pericyte—a review. Tissue Cell. 1986;18(2):153–74.

CAS  PubMed  Article  Google Scholar 

Peppiatt CM, Howarth C, Mobbs P, Attwell D. Bidirectional control of CNS capillary diameter by pericytes. Nature. 2006;443(7112):700–4.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Coureuil M, Lécuyer H, Bourdoulous S, Nassif X. A journey into the brain: insight into how bacterial pathogens cross blood–brain barriers. Nat Rev Microbiol. 2017;15(3):149–59.

CAS  PubMed  Article  Google Scholar 

McArthur S, Loiola RA, Maggioli E, Errede M, Virgintino D, Solito E. The restorative role of annexin A1 at the blood–brain barrier. Fluids Barriers CNS. 2016;13(1):17.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Wolburg H, Wolburg-Buchholz K, Fallier-Becker P, Noell S, Mack AF. Structure and functions of aquaporin-4-based orthogonal arrays of particles. Int Rev Cell Mol Biol. 2011;287:1–41.

CAS  PubMed  Article  Google Scholar 

Noell S, Wolburg-Buchholz K, Mack AF, Beedle AM, Satz JS, Campbell KP, Wolburg H, Fallier-Becker P. Evidence for a role of dystroglycan regulating the membrane architecture of astroglial endfeet. Eur J Neurosci. 2011;33(12):2179–86.

PubMed  PubMed Central  Article  Google Scholar 

Thal DR. The role of astrocytes in amyloid β-protein toxicity and clearance. Exp Neurol. 2012;236(1):1–5.

CAS  PubMed  Article  Google Scholar 

Asgari M, de Zélicourt D, Kurtcuoglu V. How astrocyte networks may contribute to cerebral metabolite clearance. Sci Rep. 2015;5:15024.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Diamond B, Honig G, Mader S, Brimberg L, Volpe B. Brain-reactive antibodies and disease. Annu Rev Immunol. 2013;31:345–85.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Blanchette M, Daneman R. Formation and maintenance of the BBB. Mech Dev. 2015;138(Pt 1):8–16.

CAS  PubMed  Article  Google Scholar 

Wu C, Ivars F, Anderson P, Hallmann R, Vestweber D, Nilsson P, Robenek H, Tryggvason K, Song J, Korpos E, et al. Endothelial basement membrane laminin alpha5 selectively inhibits T lymphocyte extravasation into the brain. Nat Med. 2009;15(5):519–27.

CAS  PubMed  Article  Google Scholar 

Ransohoff RM, Engelhardt B. The anatomical and cellular basis of immune surveillance in the central nervous system. Nat Rev Immunol. 2012;12(9):623–35.

CAS  PubMed  Article  Google Scholar 

Keaney J, Campbell M. The dynamic blood–brain barrier. FEBS J. 2015;282(21):4067–79.

CAS  PubMed  Article  Google Scholar 

Correale J, Villa A. Cellular elements of the blood–brain barrier. Neurochem Res. 2009;34(12):2067.

CAS  PubMed  Article 

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