Genetically Modified Immunomodulatory Cell-Based Biomaterials in Tissue Regeneration and Engineering

MOI

multiplicity of infection

RT–PCR

reverse transcription polymerase chain reaction

BMSC

bone marrow mesenchymal stem cells

OX40

tumor necrosis factor receptor superfamily member 4

GFP

green fluorescent protein

CXCR3

C-X-C motif chemokine receptor 3

AAV

adeno-associated virus

TIMP

tissue inhibitor of metalloproteinase

CDM

cartilage-derived matrix

hMSC

human mesenchymal stem cells

IDO1

indoleamine 2,3-dioxgenase1

BMP-7

bone morphogenetic protein-7

GDF15

growth differentiation factor 15

ADSC

adipose tissue-derived mesenchymal stem cell

KMO

kynurenine 3-monooxygenase

PDGF-B

platelet-derived growth factor B

pAEC

porcine aortic endothelial cells

GVHD

graft-versus-host disease

SLA

swine leukocyte antigen

GGTA1

α1,3GT, α1,3 galactosyltransferases

HCRPs

human complement regulatory proteins

IL-1Ra

interleukin 1 receptor antagonist

CDC

complement-dependent cytotoxicity

AVR

acute vascular rejection

SCNT

somatic cell nuclear transfer

IRI

ischemia reperfusion injury

ECM

extracellular cell matrix

TEVMP

tissue-engineered vascular microphysiological platform

DRCC

donor recipient chimeric cell

CLAD

chronic lung allograft dysfunction

SOCS3

suppressor of cytokine signaling 3

XLTx

xeno lung transplantation

IBBMTx

intrabone bone marrow transplantation

RLT

reduced-size liver transplantation

SBTx

small bowel transplantation

AKT1

serine/threonine kinase 1

AST

glutamate transaminase

REBD

recessive epidermolysis bullosa dystrophia

PAUBM

porcine acellular urinary bladder matrix

KTx

kidney transplantation

MLR

mixed lymphocyte reaction

TNFRs

tumor necrosis factor superfamily members

PDL1

programmed cell death 1 ligand 1

NF-κB

nuclear factor kappa-light-chain-enhancer of activated B cells

PBMC

peripheral blood mononuclear cells

CD47

cluster of differentiation 47

SIRPα

signal regulatory protein alpha

DST

donor-specific transfusion

GDNF

glial cell-derived neurotrophic factor

GFRAL

GDNF family receptor α-like

TGF-β

transforming growth factor-beta

circ Malat 1

malat-1 circular RNA

OX40Ig

OX40-Ig fusion protein

EAD

early allograft dysfunction

HIF-1α

hypoxia inducible factor 1 alpha

VHL

von Hippel–Lindau tumor suppressor

HCC

hepatocellular carcinoma

HLA

human leukocyte antigen

SNP

Single-nucleotide polymorphisms

MLV

murine leukemia vector

CMAH

cytidine monophospho-N-acetylneuraminic acid hydroxylase

β4GalNT2

β-1,4-N-acetylgalactosaminyl transferase 2 gene

TNF-αR

tumor necrosis factor α receptor

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